Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway

Huang, Yuntai; Guo, Lu-Bo; Chitti, Renukaradhya; Sreeharsha, Nagaraja; Mishra, Anurag; Gubbiyappa, Shiva Kumar; Singh, Yogendra

doi:10.1002/biof.1585

Cited by 24 publications

(17 citation statements)

References 49 publications

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“…For example, wogonin played protective role against myocardial infarction by repressing oxidative stress through the activation of Nrf2/HO‐1 pathway 49 . Besides, wogonin was capable of ameliorating the severity of rheumatoid arthritis and nephrotoxicity resulted from cadmium and cisplatin by lessening oxidative stress 13,14,50 . Consistent with these reports, our findings further confirmed the potent anti‐oxidative capacity of wogonin in treating septic liver injury via the activation of Nrf2.…”

Section: Discussionsupporting

confidence: 87%

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

Dai

Guo

Tan

et al. 2021

J Cellular Molecular Medi

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Sepsis is a life‐threatening organ dysfunction syndrome, and liver is a susceptible target organ in sepsis, because the activation of inflammatory pathways contributes to septic liver injury. Oxidative stress has been documented to participate in septic liver injury, because it not only directly induces oxidative genotoxicity, but also exacerbates inflammatory pathways to potentiate damage of liver. Therefore, to ameliorate oxidative stress is promising for protecting liver in sepsis. Wogonin is the compound extracted from the medicinal plant Scutellaria baicalensis Geogi and was found to exert therapeutic effects in multiple inflammatory diseases via alleviation of oxidative stress. However, whether wogonin is able to mitigate septic liver injury remains unknown. Herein, we firstly proved that wogonin treatment could improve survival of mice with lipopolysaccharide (LPS)‐ or caecal ligation and puncture (CLP)‐induced sepsis, together with restoration of reduced body temperature and respiratory rate, and suppression of several pro‐inflammatory cytokines in circulation. Then, we found that wogonin effectively alleviated liver injury via potentiation of the anti‐oxidative capacity. To be specific, wogonin activated Nrf2 thereby promoting expressions of anti‐oxidative enzymes including NQO‐1, GST, HO‐1, SOD1 and SOD2 in hepatocytes. Moreover, wogonin‐induced Nrf2 activation could suppress NF‐κB‐regulated up‐regulation of pro‐inflammatory cytokines. Ultimately, we provided in vivo evidence that wogonin activated Nrf2 signalling, potentiated anti‐oxidative enzymes and inhibited NF‐κB‐regulated pro‐inflammatory signalling. Taken together, this study demonstrates that wogonin can be the potential therapeutic agent for alleviating liver injury in sepsis by simultaneously ameliorating oxidative stress and inflammatory response through the activation of Nrf2.

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Section: Discussionsupporting

confidence: 87%

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

Dai

Guo

Tan

et al. 2021

J Cellular Molecular Medi

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“…Concurrent treatment of dexamethasone challenged rats with wogonin at either 30 mg/kg or 60 mg/kg doses improved the antioxidant defenses SOD, CAT, and GSH and alleviated dexamethasone-induced systemic oxidative imbalance. Our data are in line with previously published data which indicated that wogonin exhibits strong antioxidant activity in several in vitro and in vivo models [33,34]. It was previously reported that wogonin protects against cadmium-triggered oxidative renal injury [52].…”

Section: Effect Of Wogonin On Serum Lipid Peroxidessupporting

confidence: 93%

“…[32]. Wogonin also has been reported to have a potential antioxidant activity [33,34]. Accordingly, the current study aimed at investigating the potential protective activity of wogonin against DEX-induced oxidative stress in vivo in Sprague Dawley rats.…”

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confidence: 99%

Wogonin Hampers Dexamethasone-Induced Oxidative Imbalance in Sprague Dawely Rats

Hassanin

Tolba

Tadros

et al. 2020

Archives of Pharmaceutical Sciences Ain Shams University

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Corticosteroids are frequently used for their powerful anti-inflammatory activity in the management of various chronic inflammatory diseases. They are also used because of their potent immunosuppressive power in the manipulation of adverse effects associated with chemotherapeutic treatments. However, their long-term usage is associated with several side effects. The majority of these side effects are due to the increased oxidative stress associated with their administration. Dexamethasone (DEX) is one of the most commonly used glucocorticoids either as an anti-inflammatory and/or immunosuppressive agent. Wogonin, a mono-flavonoid present in the root of Scutellaria baicalensis Georgi, has attracted considerable attention in recent years. Wogonin has a well-documented antioxidant activity that is mainly responsible for its multiple pharmacological activities. The current study aimed at investigating the possible protective activity of wogonin against DEX-induced oxidative stress in Sprague Dawley rats. The results showed that wogonin co-treatment successfully counteracted DEX-induced oxidative stress. Co-administration of wogonin doses of 30 and 60 mg/kg/day significantly improved superoxide dismutase (SOD) activity by 1.7 (P<0.001) and 3.9 folds (P<0.001) and significantly improved catalase (CAT) activity by 1.9 and 2.2 folds (P<0.05) as compared to DEX group. Moreover, co-treatment with wogonin (30 mg/kg/day) improved reduced glutathione (GSH) level by 1.5 folds, while the higher dose significantly improved GSH level by 2.3 folds (P<0.05) as compared to DEX group. Also, co-treatment with wogonin improved serum malondialdehyde MDA level by 11.8% and 30% compared to the DEX group. In conclusion, wogonin displayed a promising protective antioxidant effect against DEX-induced oxidative stress.

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“…Surprisingly, these compounds are both flavonoids which have antioxidant and antiinflammatory effects [39][40][41][42]. For instance, researches indicated that quercetin mediate the anti-inflammatory mechanism of reducing acute laryngitis by restoring the Th17/Treg balance and activating heme oxygenase 1 and isorhamnetin increased the levels of TNF-α, IL-1β, IL-6, IL-17A, and IL-17F as well as decreased levels of IL-35 and IL-10 in the CIA mice, resulting in an anti-inflammatory effect [43,44]. Luteolin prevented cartilage destruction in OA rats in vivo through inhibiting IL-1β-induced phosphorylation of NF-κB [45].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking-Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis

Zeng

Jiang³

et al. 2021

BioMed Research International

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Qianghuo Shengshi decoction (QHSSD) is a classical Chinese medicine formula, which is used in clinical practice for the treatment of rheumatoid arthritis (RA) in China. However, the pharmacological mechanism of QHSSD on RA has remained unclear by now. We collected and screened active compounds and its potential targets by the pharmacology platform of Chinese herbal medicines. In addition, the therapeutic targets of RA were obtained and selected from databases. Network construction analyzed that 128 active compounds may act on 87 candidate targets and identified a total of 18 hub targets. GO annotation and KEGG enrichment investigated that the action mechanism underlying the treatment of RA by QHSSD might be involved in cell proliferation, angiogenesis, anti-inflammation, and antioxidation. Finally, molecular docking verification showed that TP53, VEGFA, TNF, EGFR, and NOS3 may be related to the RA treatment and molecular dynamics simulation showed the stability of protein-ligand interactions. In this work, QHSSD might exert therapeutic effect through a multicomponent, multitarget, and multipathway in RA from a holistic aspect, which provides basis for its mechanism of action and subsequent experiments.

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Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway

Cited by 24 publications

References 49 publications

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

Wogonin Hampers Dexamethasone-Induced Oxidative Imbalance in Sprague Dawely Rats

Network Pharmacology and Molecular Docking-Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis

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