“Wobbles”—an Hereditary Disease in Horses*

Dimock, W. W.

doi:10.1093/oxfordjournals.jhered.a106074

Cited by 15 publications

(8 citation statements)

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“…Early on, a genetic predisposition to CVSM in horses was suspected based on the frequency of CVSM in certain families of Thoroughbreds (Errington 1938;Dimock 1950); however, lack of many close relationships in a group of 47 horses with CVSM gave rise to thoughts on other aetiological factors (Dimock and Errington 1939). Although some investigators have failed to demonstrate genetic determination of CVSM (Falco et al 1976;Wagner et al 1985), others believe genetic factors that determine the length of the neck, cervical vertebral biomechanics and body size play a significant role in the development of CVSM (Rooney 1969(Rooney , 1972Stashak et al 1985).…”

Section: Pathogenesismentioning

confidence: 99%

Cervical vertebral stenotic myelopathy

Nout

Reed

2003

Equine Veterinary Education

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Section: Pathogenesismentioning

confidence: 99%

Cervical vertebral stenotic myelopathy

Nout

Reed

2003

Equine Veterinary Education

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“…By the mid-twentieth century equine2 genetics was already a dynamic field of study, although the number of researchers in this area was small and information about the horse genome was sparse. Research published during that time investigated the genetic bases of physiology (Braend 1967; Mathai et al 1966), coat color (Castle 1948) and disease (Dimock 1950; Trommershausen-Smith A. 1977) in the domestic horse.…”

Section: A Brief History Of Horse Genome Researchmentioning

confidence: 99%

Equine clinical genomics: A clinician's primer

Brosnahan

Brooks

Antczak³

2010

Equine Veterinary Journal

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Summary The objective of this review is to introduce equine clinicians to the rapidly evolving field of clinical genomics with a vision of improving the health and welfare of the domestic horse. For fifteen years a consortium of veterinary geneticists and clinicians has worked together under the umbrella of The Horse Genome Project. This group, encompassing 22 laboratories in 12 countries, has made rapid progress, developing several iterations of linkage, physical and comparative gene maps of the horse with increasing levels of detail. In early 2006, the research was greatly facilitated when the U.S. National Human Genome Research Institute of the National Institutes of Health added the horse to the list of mammalian species scheduled for whole genome sequencing. The genome of the domestic horse has now been sequenced and is available to researchers worldwide in publicly accessible databases. This achievement creates the potential for transformative change within the horse industry, particularly in the fields of internal medicine, sports medicine and reproduction. The genome sequence has enabled the development of new genome-wide tools and resources for studying inherited diseases of the horse. To date, researchers have identified eleven mutations causing ten clinical syndromes in the horse. Testing is commercially available for all but one of these diseases. Future research will probably identify the genetic bases for other equine diseases, produce new diagnostic tests and generate novel therapeutics for some of these conditions. This will enable equine clinicians to play a critical role in ensuring the thoughtful and appropriate application of this knowledge as they assist clients with breeding and clinical decision-making.

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“…Lacking specificity of gait scoring for breeding purposes may relate to the fact that certain unfavorable movement characteristics that are long known still occur. Hereditary influences on impaired coordination in equines have been suggested as early as in the first half of the 20th century (Dimock and Errington, 1939;Dimock, 1950). In a recent study, indications of imbalance (IMB) were found in almost equal proportions of warmblood foals and presumptive warmblood broodmares, and genetic analyses implied relevant genetic determination and opportunities to select against unfavorable movement characteristics and for better balance in movement in juvenile and adult horses (Becker et al, 2011b).…”

Section: Introductionmentioning

confidence: 99%

Correlations of unfavorable movement characteristics in warmblood foals and mares with routinely assessed conformation and performance traits

Becker

Stock

Distl

2013

Animal

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New movement traits reflecting unfavorable movement characteristics were defined on the basis of detailed movement evaluations (DME) of warmblood foals and mares performed in connection with regular breeding events of the Oldenburg horse breeding societies in 2009 and 2010. DME information was available for 3374 foals and 2844 mares and used for correlation analyses with conformation information on 1987 mares from studbook inspections (SBI) in 2009 and performance information on 2758 mares from mare performance tests (MPT) in 2000 to 2008. Analyses of variance revealed few significant differences between scores for SBI and MPT traits in mares without and with indications of imbalance (IMB) in general or specific findings like irregular tail tone or posture (TTP). SBI scores for general impression and development were significantly lower and MPT scores for trot under rider tended to be higher in IMB-positive mares. Genetic parameters were estimated in linear animal models with residual maximum likelihood. Additive genetic correlations and Pearson correlation coefficients between univariately predicted breeding values indicated unfavorable genetic correlations of IMB and TTP with dressage-related conformation and performance traits. For SBI and MPT traits, we found similarities between the correlation patterns for DME traits in foals and mares. The results implied that breeding of dressage horses may benefit from revision of current movement evaluation and consideration of specific movement characteristics.

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“Wobbles”—an Hereditary Disease in Horses*

Cited by 15 publications

References 0 publications

Cervical vertebral stenotic myelopathy

Cervical vertebral stenotic myelopathy

Equine clinical genomics: A clinician's primer

Correlations of unfavorable movement characteristics in warmblood foals and mares with routinely assessed conformation and performance traits

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