Woad extract containing cream improves significantly dry, irritated, and pruritic skin

Abstract

Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating scale [NRS], dynamic pruritus score [DPS]), skin dryness (itch‐controlled days [ItchCD], overall dry skin [ODS]), transepidermal water loss (TEWL), skin hydration and quality of life (5PLQ, DLQI). All sensorial characteristics were well perceived (>4), with tolerability (4.77 ± 0.47) and no negative skin feelings (4.73 ± 0.74) achieving the highest scores (0–5 scale). Dry skin and symptoms improved significantly (p < .001) for all variables: NRS (from 4.8 ± 1.74 to 1.83 ± 2.18), ItchCD (from 8.23 ± 4.40 to 4.81 ± 4.07), ODS (from 1.80 ± 0.85 to 0.65 ± 0.65), hydration (23.33 ± 1.33 to 40.70 ± 1.86), and quality of life (5PLQ: from 7.12 ± 4.25 to 4.24 ± 3.67; DLQI: from 5.29 ± 4.79 to 3.00 ± 3.98). The DPS revealed a moderate antipruritic effect. The TEWL decreased slightly (p = .511). No side effects were reported. The study suggests that, the cream is effective, and well tolerated in treating dry, irritated, and pruritic skin.

Solvent polarity mediates phytochemical yield and antioxidant capacity of Isatis tinctoria

“…Lipophilic extracts of woad have shown anti-inflammatory responses. Lipophilic woad extract in vivo studies strongly supports anti-inflammatory response such as in skin erythema (Forner et al, 2019; Marcelo, Gontier & Dauwe, 2019). The selection of solvents for extraction plays an important role in the quantity and quality of extracts.…”

Chronic prurigo: Insufficient disease control in spite of high healthcare usage

“…Patients completed a questionnaire assessing disease duration, itch intensity [numerical rating scale (NRS)] and impairment of quality of life [5-item pruritus quality of life questionnaire (5PLQ)]. 5 Results of the patient-reported outcomes and inclusion/exclusion criteria were previously reported. 6,7 We used Kruskal-Wallis tests with Bonferroni correction and Spearman's rho for statistics.…”

The Effects of Fig Tree (Ficus carica L.) Leaf Aqueous Extract on Seed Germination and Seedling Growth of Three Medicinal Plants

“…is a cruciferous plant that is a heliophile, cold-resistant, and tolerant to harsh conditions. It is a traditional Chinese medicinal plant that has the function of treating viral infection and inflammation and has been used clinically for centuries [24][25][26].…”