wo New Alkaloids from Pleurotus ostreatus (Jacq. :Pers.) Roll

Zhu, Lijie; Han, Xianwei; Cui, Xiao; Li, Shuang; Liao, Qiao; Rui-jie, Chen

doi:10.25135/rnp.166.19.11.1480

Cited by 3 publications

(3 citation statements)

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“…It should be noted that during the 2002–2022 period, new studies were carried out evaluating the bioactivity of some terpendoles [ 120 , 121 , 122 , 123 , 124 , 125 , 126 ]. Three new terpendoles produced by the fungus Volutella citronella , two of them named terpendoles N and O ( 90 and 91 , Figure 6 ), were reported in another study [ 127 ], but their structures were different to those published by Zhu et al (2020) [ 55 ]. In fact, the new structure for terpendole N differed significantly because the indole system contains an amide group.…”

Section: New Alkaloids Found In Mushroom Since 2002mentioning

confidence: 88%

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Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Zorrilla

Evidente

2022

Biomolecules

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Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of organisms have also been proven to synthesize bioactive alkaloids, such as animals, marine organisms, bacteria, and fungi. This review covers the findings of the last 20 years (2002–2022) related to the isolation, structures, and biological activities of the alkaloids produced by mushrooms, a fungal subgroup, and their potential to develop drugs and agrochemicals. In some cases, the synthesis of the reviewed compounds and structure−activity relationship studies have been described.

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Section: New Alkaloids Found In Mushroom Since 2002mentioning

confidence: 88%

“…Terpendoles N and O ( 88 and 89 , Figure 6 ) were isolated as new compounds from Pleurotus ostreatus [ 55 ]. The last time a new compound of the terpendole family was discovered was in 1999, when terpendole M was isolated from the fungus Neotyphodium lolii [ 119 ].…”

Section: New Alkaloids Found In Mushroom Since 2002mentioning

confidence: 99%

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Zorrilla

Evidente

2022

Biomolecules

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“…However, currently only about 14 terpenoids have been identified in P. ostreatus, 11 of them from liquid hyphae fermentation and three of them from the fruiting body (see Figure S1 in the Supporting Information). − These numbers are relatively low compared with other basidiomycete fungi. For example, at least 36 terpenoids have been isolated from the edible and medicinal basidiomycete fungi Hericium erinaceus. − Thus, activating silent genes and exploring the terpenoid diversity of P.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel Terpenoids from the Basidiomycete Pleurotus ostreatus through Genome Mining and Coculture Optimization

Wang

et al. 2023

J. Agric. Food Chem.

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In our previous work, postredienes A−C, three unusual linear sesterterpenes with high antifungal activities, were isolated from Pleurotus ostreatus SY10 when cocultured with Trametes robiniophila SY636. However, their titers were low, and exploration of newly biosynthesized trace analogues is required. Herein, genome mining analysis predicted that 17 gene clusters are involved in terpenoid biosynthesis in P. ostreatus. Thus, coculture conditions for strains SY10 and SY636 were optimized using a single-factor test and Box−Behnken design. As a result, the titers of postredienes A−C were increased by over 2.5-fold, reaching 1.28 to 8.40 mg/L. Moreover, five new terpenoids, named postredienes D−H (1−5), were successfully isolated. Compound 1 exhibited activities against the human pathogenic fungi Candida albicans and Cryptococcus neoformans comparable to those of amphotericin B. Compound 2 represents a novel sesterterpene with a five-membered ring at C-7. The absolute configurations of 1−5 were elucidated by making the methoxyphenylacetic acid esters and acetonide derivatives, combined with ECD and NMR calculation. Two potential gene clusters and relevant biosynthetic pathways for 1−5 were subsequently proposed based on real-time reverse transcriptionquantitative PCR (RT-qPCR) analysis. The current study provides new insights into the research of terpenoid biosynthesis genes in P. ostreatus and other basidiomycetes.

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Alkaloids of forest fungi: diversity and therapeutic applications

Anaele,

Nwafor

2025

Forest Fungi

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wo New Alkaloids from Pleurotus ostreatus (Jacq. :Pers.) Roll

Cited by 3 publications

References 0 publications

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Discovery of Novel Terpenoids from the Basidiomycete Pleurotus ostreatus through Genome Mining and Coculture Optimization

Alkaloids of forest fungi: diversity and therapeutic applications

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