WNT5A in tumor development and progression: A comprehensive review

Bueno, Maura Lima Pereira; Saad, Sara Teresinha Olalla; Roversi, Fernanda Marconi

doi:10.1016/j.biopha.2022.113599

Cited by 14 publications

(10 citation statements)

References 89 publications

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“…It has been reported that WNT5A can activate noncanonical WNT signaling pathways by binding to a series of its receptors, such as frizzled (Fzd) or Ror family members [ 35 ]. Although WNT5A functions in RCC cells have not yet been clearly revealed, WNT5A signaling is crucial for regulating the proliferation and invasion of many other cancer cells [ 20 ]. Reports have shown that WNT5A has both oncogenic functions and tumor-suppressive functions in different cancers [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Reports have shown that WNT5A has both oncogenic functions and tumor-suppressive functions in different cancers [ 35 ]. For instance, WNT5A suppresses cell growth and invasion in colon and thyroid cancer [ 20 ]. Studies have also shown that WNT5A can induce EMT and cell motility in lung cancer, prostate cancer, and melanoma [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, WNT5A suppresses cell growth and invasion in colon and thyroid cancer [ 20 ]. Studies have also shown that WNT5A can induce EMT and cell motility in lung cancer, prostate cancer, and melanoma [ 20 ]. Here, we demonstrated that PRMT2 activates WNT5A expression, which stimulates the Wnt signaling cascade and increases β-Catenin, c-Myc, and Snail-1 expression.…”

Section: Discussionmentioning

confidence: 99%

“…The binding of Wnt family members or their receptors is considered to be the beginning of Wnt signaling stimulation [ 19 ]. Wnt family member 5A (WNT5A), an important Wnt protein family member, can strongly activate the Wnt signaling pathway by binding to the FZD4-LPR5 complex receptor and then accumulating β-Catenin, which contributes to poor outcomes in cancer patients [ 20 ]. At present, Wnt signaling has been confirmed to be overactivated in RCC progression [ 21 ], but the detailed mechanism of how the Wnt signaling pathway is activated in RCC cells has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

Li,

Chen,

Yong

et al. 2023

Cell Death Dis

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Protein arginine methyltransferase 2 (PRMT2) is involved in several biological processes via histone methylation and transcriptional regulation. Although PRMT2 has been reported to affect breast cancer and glioblastoma progression, its role in renal cell cancer (RCC) remains unclear. Here, we found that PRMT2 was upregulated in primary RCC and RCC cell lines. We demonstrated that PRMT2 overexpression promoted RCC cell proliferation and motility both in vitro and in vivo. Moreover, we revealed that PRMT2-mediated H3R8 asymmetric dimethylation (H3R8me2a) was enriched in the WNT5A promoter region and enhanced WNT5A transcriptional expression, leading to activation of Wnt signaling and malignant progression of RCC. Finally, we confirmed that high PRMT2 and WNT5A expression was strongly correlated with poor clinicopathological characteristics and poor overall survival in RCC patient tissues. Our findings indicate that PRMT2 and WNT5A may be promising predictive diagnostic biomarkers for RCC metastasis. Our study also suggests that PRMT2 is a novel therapeutic target in patients with RCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

Li,

Chen,

Yong

et al. 2023

Cell Death Dis

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“…63 WNT5A, as an evolutionary WNT member, can activate both the canonical Wnt/β-catenin and noncanonical Wnt/Ca 2+ pathways. 64,65 It was found that WNT5A was highly expressed in psoriasis lesions, yet the specific mechanisms were still unclear. 66 Sato et al demonstrated that WNT5A-receptor tyrosine kinase-like orphan receptor (ROR2) axis can enhance interferon-γ (IFN-γ) signaling and promote IL-12 expression in DCs, inducing T helper 1 (Th1) differentiation in colitiss.…”

Section: Shokrollah Et Al Have Shed Light On Potential Novel Biomarke...mentioning

confidence: 99%

Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics

Zhang,

Feng,

Chen

et al. 2024

Skin Research and Technology

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BackgroundMounting evidence suggest that there are an association between psoriasis and ulcerative colitis (UC), although the common pathogeneses are not fully understood. Our study aimed to find potential crucial genes in psoriasis and UC through machine learning and integrated bioinformatics.MethodsThe overlapping differentially expressed genes (DEGs) of the datasets GSE13355 and GSE87466 were identified. Then the functional enrichment analysis was performed. The overlapping genes in LASSO, SVM‐RFE and key module in WGCNA were considered as potential crucial genes. The receiver operator characteristic (ROC) curve was used to estimate their diagnostic confidence. The CIBERSORT was conducted to evaluate immune cell infiltration. Finally, the datasets GSE30999 and GSE107499 were retrieved to validate.Results112 overlapping DEGs were identified in psoriasis and UC and the functional enrichment analysis revealed they were closely related to the inflammatory and immune response. Eight genes, including S100A9, PI3, KYNU, WNT5A, SERPINB3, CHI3L2, ARNTL2, and SLAMF7, were ultimately identified as potential crucial genes. ROC curves showed they all had high confidence in the test and validation datasets. CIBERSORT analysis indicated there was a correlation between infiltrating immune cells and potential crucial genes.ConclusionIn our study, we focused on the comprehensive understanding of pathogeneses in psoriasis and UC. The identification of eight potential crucial genes may contribute to not only understanding the common mechanism, but also identifying occult UC in psoriasis patients, even serving as therapeutic targets in the future.

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Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma

Solairaja,

Venkatabalasubramanian

2024

J Membrane Biol

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WNT5A in tumor development and progression: A comprehensive review

Cited by 14 publications

References 89 publications

PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression

Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics

Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma

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