2013
DOI: 10.2106/jbjs.l.01502
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Wnt3a Reestablishes Osteogenic Capacity to Bone Grafts from Aged Animals

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Cited by 52 publications
(77 citation statements)
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References 75 publications
(88 reference statements)
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“…A circumferential, full-thickness defect with a 2-mm diameter calvarial defect was created as described in mice [38].…”
Section: Skeletal Surgeriesmentioning
confidence: 99%
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“…A circumferential, full-thickness defect with a 2-mm diameter calvarial defect was created as described in mice [38].…”
Section: Skeletal Surgeriesmentioning
confidence: 99%
“…In previous work we cataloged the distribution of canonical and non-canonical Wnt ligands in the intact and injured skeleton, and this analysis revealed that Wnt3a was most broadly expressed [37]. Further, the expression level of Wnt3a was the most severely affected by aging [38]. Consequently, our study here focused on delivery of WNT3A to autografts from aged animals.…”
Section: Introductionmentioning
confidence: 99%
“…This is in line with a recent published work of Oliver et al [37], where the fracture callus in the OVX group was filled with soft tissue and cartilage remnants. Fatty degradation of bone marrow in the elderly, which is associated with a decreased load-bearing capacity and accordingly a higher osteoporotic-related fracture risk, is regulated by beta-catenin-dependent Wnt signaling [8]. This pathway determines mesenchymal stem cells to differentiate into an osteogenic or adipogenic lineage, thus a manipulation of this signaling can influence the bone mass [8].…”
Section: Osteoporotic Bone Healingmentioning
confidence: 99%
“…Fatty degradation of bone marrow in the elderly, which is associated with a decreased load-bearing capacity and accordingly a higher osteoporotic-related fracture risk, is regulated by beta-catenin-dependent Wnt signaling [8]. This pathway determines mesenchymal stem cells to differentiate into an osteogenic or adipogenic lineage, thus a manipulation of this signaling can influence the bone mass [8]. In osteoporotic bone, bone morphogenetic proteins (BMP) play also an important role by regulation of the BMPWnt-RANKL axis.…”
Section: Osteoporotic Bone Healingmentioning
confidence: 99%
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