Wnt3a promotes melanin synthesis of mouse hair follicle melanocytes

Guo, Haiying; Yang, Kang; Deng, Fang; Ye, Jixing; Xing, Yizhan; Li, Yuhong; Lian, Xiaohua; Yang, Tian

doi:10.1016/j.bbrc.2012.03.077

Cited by 44 publications

(29 citation statements)

References 34 publications

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“…5D). WNT ligands are secreted by HF epithelium and help to maintain proper epithelial-mesenchymal interaction during anagen (36,39–41). We found that Wnt3a levels were diminished between 24 and 48hrs post-IR, but later rebounded from 72hrs onward at the base of the epithelial strand (Fig.…”

Section: Resultsmentioning

confidence: 99%

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

et al. 2017

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Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sensitive transit-amplifying cells (TAC) that maintain hair growth. How genotoxicity-induced HF injury is repaired remains unclear. We report here that HF mobilize ectopic progenitors from distinct TAC compartments for regeneration in adaptation to the severity of dystrophy induced by ionizing radiation (IR). Specifically, after low-dose IR, keratin5+ basal hair bulb progenitors, rather than bulge SC, were quickly activated to replenish matrix cells and regenerated all concentric layers of HF, demonstrating their plasticity. After high-dose IR, when both matrix and hair bulb cells were depleted, the surviving outer root sheath cells rapidly acquired a SC-like state and fueled HF regeneration. Their progeny then homed back to SC niche and supported new cycles of HF growth. We also revealed that IR induced HF dystrophy and hair loss and suppressed WNT signaling in a p53- and dose-dependent manner. Augmenting WNT signaling attenuated the suppressive effect of p53 and enhanced ectopic progenitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induced alopecia. Hence, targeted activation of TAC-derived progenitor cells, rather than quiescent bulge SC, for anagen HF repair can be a potential approach to prevent hair loss from chemotherapy and radiotherapy.

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Section: Resultsmentioning

confidence: 99%

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

et al. 2017

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“…Hair morphogenesis is also regulated by the Wnt/ β -catenin signaling pathway. Wnt3a signaling was activated in mouse hair follicle melanocytes during the anagen phase of C57BL/6J (B6) mice (Guo et al 2012). In addition to melanocytes, adjacent keratinocytes expressed Wnt3a during the anagen phase.…”

Section: Eff Ects Of γ -Rays On Pigmentation Of Regenerated Hair Follmentioning

confidence: 98%

Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

Sugaya¹,

Hirobe²

2013

International Journal of Radiation Biology

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“…Melanocytes begin to shut down melanogenesis in late anagen and regression phase called catagen, and it die by apoptosis on the hair bulb in rest phase called telogen. The melanogenesis in melanocytes reappears when hair follicles reenter anagen [7][8][9][10]. The prevention of melanogenesis in the hair bulb on anagen is induced by the aging or stress which results in gray hair.…”

Section: Melanin Biosynthesismentioning

confidence: 99%

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Mitsunaga

Yamauchi

2015

J Wood Sci

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Controlling melanogenesis is important for maintaining the good health and cosmetic appearance of a human body. This study aims to search the active compounds from natural products exhibiting the melanogenesis modulating activity and elucidate the mechanism underlying the observed activity. Two novel quercetin glycosideswere isolated and identified from Helminthostachys zeylanica roots 50 % ethanol extract. Compound 1 exhibited intracellular melanogenesis stimulatory activity, while 2 showed no effect even the structural similarity. To understand the structure-activity relationships, twelve quercetin glycosides and seven methylquercetins were synthesized from rutin as starting material. As the result of bioassay using synthesized nineteen quercetin derivatives in B16 melanoma cells, some quercetin-3-O-b-D-glucopyranosides stimulated the intracellular melanogenesis. On the other hand, synthesized 3-O-methylquercetin 12 and 3,4 0 ,7-Otrimethylquercetin 15 increased both intra and extracellular melanin contents with no cytotoxicity. Compoud 15 increased the phosphorylated p38 mitogen-activated protein kinase (MAPK) and microphthalmia-associated transcription factor (MITF) which regulates the expression of tyrosinase, TRP-1 and TRP-2. While 12 enhanced the expression of the melanogenic enzymes without involving the MITF, as evidenced by its lack of any stimulation of the expression of MITF and p-p38 MAPK. This result indicates that 12 may stimulate the expression of tyrosinase, TRP-1, and TRP-2 by stimulating currently unidentified transcriptional factors and/or by regulating the degradation of melanogenic enzymes.

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Wnt3a promotes melanin synthesis of mouse hair follicle melanocytes

Cited by 44 publications

References 34 publications

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

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