Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis

Yamashiro, Takashi; Li, Zheng; Shitaku, Yuko; Saito, Masahiro; Tsubakimoto, Takanori; Takada, Kenji; Takano‐Yamamoto, Teruko; Thesleff, Irma

doi:10.1111/j.1432-0436.2006.00150.x

Cited by 142 publications

(166 citation statements)

References 47 publications

(60 reference statements)

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…In particular, Sulf1 activity has been shown to decrease the affinity of HS toward the Wnt ligand and promote the binding of Wnt to its cognate receptor Frizzled, thereby acting as a positive regulator of Wnt signaling (38). From these findings, together with those of our previous study (26), we hypothesized that Wnt ligands, especially Wnt10a, can be captured by cell surface or basement membrane extracellular matrix molecules to control the differentiation of pulp cells into odontoblasts and that such regulation of Wnt signaling is modulated by the Sulf enzymes.…”

supporting

confidence: 66%

“…Mouse Sulf1 and Sulf2 probes were generated from a 461-bp Sulf1 fragment spanning the region between 124 and 584 in accession number AY101178 and a 459-bp Sulf2 fragment spanning the region between 3056 and 3514 in accession number AY101178. The preparation of Wnt10a, Dspp, and Axin2 RNA probes has been described previously (23,26).…”

Section: Methodsmentioning

confidence: 99%

“…Among the numerous Wnt genes that are expressed in developing tooth germs, Wnt10a is specifically expressed in odontoblasts. Interestingly, the forced expression of Wnt10a induced Dspp expression when the transfected cells were cultured on Matrigel (26), indicating that Wnt10a is an upstream gene involved in Dspp expression. In addition, human WNT10A mutations were reported to be associated with hypodontia (27,28).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Roles of Heparan Sulfate Sulfation in Dentinogenesis

Hayano¹,

Kurosaka²,

Yanagita³

et al. 2012

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Background: Cell surface heparan sulfate is an essential regulator of cell signaling. Results: Sulf 6-O-endosulfatase deficiency results in degenerative phenotypes, and HSPG sulfation status induces Wnt10a-mediated activation of odontoblast differentiation. Conclusion: Sulf-mediated desulfation is an important modification for the activation of the Wnt signaling in odontoblasts. Significance: This is the first molecular evidence for the functional roles of HSPG sulfation in dentin formation.

show abstract

supporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Roles of Heparan Sulfate Sulfation in Dentinogenesis

Hayano¹,

Kurosaka²,

Yanagita³

et al. 2012

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…WNT genes are involved in hair-follicle morphogenesis, 27,28 skin and tooth embryogenesis [29][30][31] and several other developmental processes. 32 It also explains that in addition to TA, hypoplastic morphological dental features, including conical tooth shapes and microdontia, occur in the permanent teeth which did develop.…”

Section: Discussionmentioning

confidence: 99%

Variability in dentofacial phenotypes in four families with WNT10A mutations

et al. 2014

View full text Add to dashboard Cite

This article describes the inter-and intra-familial phenotypic variability in four families with WNT10A mutations. Clinical characteristics of the patients range from mild to severe isolated tooth agenesis, over mild symptoms of ectodermal dysplasia, to more severe syndromic forms like odonto-onycho-dermal dysplasia (OODD) and Schö pf-Schulz-Passarge syndrome (SSPS). Recurrent WNT10A mutations were identified in all affected family members and the associated symptoms are presented with emphasis on the dentofacial phenotypes obtained with inter alia three-dimensional facial stereophotogrammetry. A comprehensive overview of the literature regarding WNT10A mutations, associated conditions and developmental defects is presented. We conclude that OODD and SSPS should be considered as variable expressions of the same WNT10A genotype. In all affected individuals, a dished-in facial appearance was observed which might be helpful in the clinical setting as a clue to the underlying genetic etiology.

show abstract

“…2B) (Thesleff et al 2001). One of these signals, Wnt10b, was suggested to regulate the expression of dentin sialophosphoprotein (Dspp) and odontoblast differentiation (Yamashiro et al 2007). The localization of Wnt reporter activity in odontoblasts is also in line with the role of Wnts in the process .…”

Section: Signaling Network Regulating Tooth Developmentmentioning

confidence: 99%

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Jussila

Thesleff²

2012

Cold Spring Harbor Perspectives in Biology

225

209

View full text Add to dashboard Cite

SUMMARYTeeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth organogenesis is regulated by an intricate network of cell -cell signaling during all steps of development. The dental hard tissues, dentin, enamel, and cementum, are formed by unique cell types whose differentiation is intimately linked with morphogenesis. During evolution the capacity for tooth replacement has been reduced in mammals, whereas teeth have acquired more complex shapes. Mammalian teeth contain stem cells but they may not provide a source for bioengineering of human teeth. Therefore it is likely that nondental cells will have to be reprogrammed for the purpose of clinical tooth regeneration. Obviously this will require understanding of the mechanisms of normal development. The signaling networks mediating the epithelial-mesenchymal interactions during morphogenesis are well characterized but the molecular signatures of the odontogenic tissues remain to be uncovered. Outline

show abstract

Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis

Cited by 142 publications

References 47 publications

Roles of Heparan Sulfate Sulfation in Dentinogenesis

Roles of Heparan Sulfate Sulfation in Dentinogenesis

Variability in dentofacial phenotypes in four families with WNT10A mutations

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Contact Info

Product

Resources

About