Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu, Jiaqi; Xiao, Qing; Xiao, Jiani; Niu, Chenxi; Li, Yuanyuan; Zhang, Xiaojun; Zhou, Zhengwei; Shu, Guang; Yin, Gang

doi:10.1038/s41392-021-00762-6

Cited by 784 publications

(572 citation statements)

References 340 publications

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“…Under physiological circumstances, the binding of Wnt-protein ligand to a membrane receptor initiates an intracellular cascade that disrupts the destruction of the b-catenin complex, consisting of axin, APC, CK1a, and GSK3b [ 87 ]. Consequently, the accumulation of b-catenin into the nucleus, and the interaction with specific transcription factors promote cell proliferation and morphogenesis [ 88 ]. The immunohistochemical distribution pattern of b-catenin was examined in an extensive series of 149 different sellar tumors, including PAs, CPs, arachnoid cysts, RCCs, and XGs [ 89 ].…”

Section: Beyond Imaging Diagnosis: the Molecular Profile Of Sellar Xa...mentioning

confidence: 99%

Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity

Lozovanu

Georgescu

Florescu³

et al. 2022

JPM

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Xanthogranuloma of the sellar region is a rare chronic inflammatory lesion resulting from secondary hemorrhage, inflammation, infarction, and necrosis of an existing Rathke’s cleft cyst, craniopharyngioma, or pituitary adenoma. Sellar xanthogranulomas are challenging to differentiate from other cystic lesions preoperatively due to the lack of characteristic imaging features. We performed a literature overview of the clinical and paraclinical features, treatment options, and long-term outcomes of patients with sellar xanthogranuloma, focusing on the preoperative radiological diagnosis. The hyperintense signal in both T1- and T2-weighted sequences, cystic or partially cystic morphology, ovoid shape, sellar epicenter, intra- and suprasellar location, intratumoral calcifications, linear rim contrast enhancement, and the absence of cavernous sinus invasion suggest xanthogranuloma in the preoperative differential diagnosis. An endoscopic endonasal gross total resection without radiotherapy is the preferred first-line treatment. Given the low rate of recurrence rate and low chance of endocrinological recovery, a mass reduction with decompression of the optic apparatus may represent an appropriate surgical goal. Identifying the xanthogranulomas’ mutational profile could complement histopathological diagnosis and give insight into their histo-pathogenesis. A better preoperative neuroimagistic diagnosis of sellar xanthogranulomas and differentiation from lesions with a poorer prognosis, such as craniopharyngioma, would result in an optimal personalized surgical approach.

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Section: Beyond Imaging Diagnosis: the Molecular Profile Of Sellar Xa...mentioning

confidence: 99%

Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity

Lozovanu

Georgescu

Florescu³

et al. 2022

JPM

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“…Our study found that SFRP5 was unexpectedly up-regulated (3-folds) in the high-risk group, and the reason may be caused by the epigenetic silencing of SFRP5 in the high-risk group (Su et al, 2010). In addition, as the Wnt pathway plays a pivotal role in organ development (Liu et al, 2022), it is not difficult to explain why lots of the DEGs are associated with organ development in our study.…”

Section: Discussionmentioning

confidence: 56%

Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer

Dai

2022

Front. Cell Dev. Biol.

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Histone acetylation is one of the most common epigenetic modifications, which plays an important role in tumorigenesis. However, the prognostic role of histone acetylation-regulators in ovarian cancer (OC) remains little known. We compared the expression levels of 40 histone acetylation-related genes between 379 OC samples and 88 normal ovarian tissues and identified 37 differently expressed genes (DEGs). We further explored the prognostic roles of these DEGs, and 8 genes were found to be correlated with overall survival (p < 0.1). In the training stage, an 8 gene‐based signature was conducted by the least absolute shrinkage and selector operator (LASSO) Cox regression. Patients in the training cohort were divided into two risk subgroups according to the risk score calculated by the 8-gene signature, and a notable difference of OS was found between the two subgroups (p < 0.001). The 8-gene risk model was then verified to have a well predictive role on OS in the external validation cohort. Combined with the clinical characteristics, the risk score was proved to be an independent risk factor for OS. In conclusion, the histone acetylation-based gene signature has a well predictive effect on the prognosis of OC and can potentially be applied for clinical treatments.

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“…Activation of the pathway and recruitment of Axin and associated proteins (GSK3β, CK1α, APC) to Fz-LRP5/6 in the membrane negatively regulates the β-catenin destruction complex. β-catenin can then translocate to the nucleus to act as a transcription factor for genes that encode proteins involved in cell proliferation, differentiation, and stem cell maintenance [ 62 ] ( Figure 3 , panel A). In the non-canonical PCP pathway, WNT ligands bind to Fzd receptors and the RAR-related orphan receptor (ROR) and signals to the cytoplasmic phosphoprotein Dishevelled (DVL), which activates Rho-associated (ROCK) or the JUN-N-terminal kinase (JNK), thus inducing gene expression by the activator protein-1 (AP-1) [ 63 ] involved in cytoskeletal rearrangement, cell motility, and coordinated cell polarity ( Figure 3 , panel B).…”

Section: Wnt In Lung Cancermentioning

confidence: 99%

TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer

Martín-Medina

Cerón-Pisa

Martinez-Font

et al. 2022

IJMS

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The most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is crucial to developing new targeted therapies. Toll-like receptors (TLRs) are master regulators of the immune responses, and their dysregulation in lung cancer is linked to immune escape and promotes tumor malignancy by facilitating angiogenesis and proliferation. On the other hand, over-activation of the WNT signaling pathway has been reported in lung cancer and is also associated with tumor metastasis via induction of Epithelial-to-mesenchymal-transition (EMT)-like processes. An interaction between both TLRs and the WNT pathway was discovered recently as it was found that the TLR pathway can be activated by WNT ligands in the tumor microenvironment; however, the implications of such interactions in the context of lung cancer have not been discussed yet. Here, we offer an overview of the interaction of TLR-WNT in the lung and its potential implications and role in the oncogenic process.

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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Cited by 784 publications

References 340 publications

Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity

Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity

Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer

TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer

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