Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy

Ma, Qian; Yu, Jinghu; Zhang, Xu; Wu, Xiaoling; Deng, Guangcun

doi:10.1016/j.biochi.2023.03.001

Cited by 23 publications

(14 citation statements)

References 101 publications

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“…Reduced Wnt/β-catenin activity clearly degrades intrinsic regenerative ability, while blocking this signaling pathway can restrain cell proliferation and induce cell apoptosis. − Downregulation of Wnt/β-catenin signaling is the reason why endoplasmic reticulum stress suppresses IEC proliferation and stem cell expansion to destroy epithelial integrity . In addition, Wnt signaling has been shown to inhibit apoptosis through activating β-catenin/TCF-coordinated transcription, and active β-catenin increases cell survival by suppressing the Bax protein. − Gln protects Alzheimer’s disease mice from oxidative stress-triggered injury through activation of the Wnt3a/β-catenin signaling pathway . In this study, GSEA showed that Gln significantly activated the Wnt/β-catenin signaling pathway, and Western blotting further confirmed that Gln upregulated the expression of key target proteins involved in Wnt/β-catenin signaling, such as active-β-catenin, β-catenin, TCF4, c-Myc, and cyclin D1.…”

Section: Discussionmentioning

confidence: 99%

Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway

Fang,

Lu,

Cheng

et al. 2024

J. Agric. Food Chem.

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Glutamine (Gln) is a critical nutrient required by neonatal mammals for intestinal growth, especially for newborn piglets. However, the mechanisms underlying the role of Gln in porcine intestinal epithelium development are not fully understood. The objective of the current study was to explore the possible signaling pathway involved in the promotion of porcine intestinal epithelial cell (IPEC-J2) proliferation by Gln. The results showed that 1 mM Gln promoted IPEC-J2 cell proliferation, and tandem mass tag proteomics revealed 973 differentially expressed proteins in Gln-treated IPEC-J2 cells, 824 of which were upregulated and 149 of which were downregulated. Moreover, gene set enrichment analysis indicated that the Wnt signaling pathway is activated by Gln treatment. Western blotting analysis further confirmed that Gln activated the Wnt/β-catenin signaling pathway. In addition, Gln increased not only cytosolic β-catenin but also nuclear β-catenin protein expression. LF3 (a β-catenin/TCF4 interaction inhibitor) assay and β-catenin knockdown demonstrated that Gln-mediated promotion of Wnt/β-catenin signaling and cell proliferation were blocked. Furthermore, the inhibition of TCF4 expression suppressed Gln-induced cell proliferation. These findings further confirmed that Wnt/β-catenin signaling is involved in the promotion of IPEC-J2 cell proliferation by Gln. Collectively, these findings demonstrated that Gln positively regulated IPEC-J2 cell proliferation through the Wnt/β-catenin pathway. These data greatly enhance the current understanding of the mechanism by which Gln regulates intestinal development.

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Section: Discussionmentioning

confidence: 99%

Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway

Fang,

Lu,

Cheng

et al. 2024

J. Agric. Food Chem.

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“…45 The Wnt signaling pathway plays a fundamental role in embryonic development and maintaining physiological balance, but its deregulation has been associated with the onset and advancement of different types of tumors, notably MB. 46,47 The Wnt/β-catenin signaling pathway can be suppressed in MB cells as a result of curcumin therapy by activating glycogen synthase kinase (GSK)3β (Figure 1), a negative regulator of the Wnt/β-catenin signaling pathway, which in turn suppresses β-catenin and its downstream target cyclin D1. 45 In another in vitro study, the significance of SHH signaling pathway suppression in therapeutic events of this component of turmeric (0-40 μM) against MB cells (DAOY, MED-1, MED-4, and MED-5) was highlighted by similar methods to the previous study.…”

Section: Curcumin and Medulloblastomamentioning

confidence: 99%

Protective Effects of Curcumin Against Medulloblastoma: A Review

Elahi,

Arefnezhad,

Sattar-Shamsabadi

et al. 2024

Natural Product Communications

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Medulloblastoma (MB) is the most common childhood tumor with a poor prognosis. Primary approaches for treating MB comprise surgical resection along with radiotherapy and chemotherapy. However, these methods have not created a promising outlook for subjects with this neuroepithelial tumor due to their low efficiency. On the other hand, these therapeutic strategies are associated with many side effects. So, there is an unmet need to find an alternative way to overcome MB. Currently, there is a significant focus on natural compound-based therapies, particularly curcumin obtained from Curcuma longa, for ameliorating different disorders like cancer. Extensive research has also been conducted to provide evidence supporting the beneficial effects of curcumin in the treatment of MB. This polyphenolic compound can exert its suppressive effects on the proliferation and growth of MB cells by affecting several molecular pathways and agents, such as suppressing Wnt/β-catenin, NF-κB, and SHH signaling pathways, triggering apoptosis-related genetic effectors (eg, Bax, Bcl-2, PARP, caspase-3, and caspase-9), potentiating tubulin acetylation, and decreasing HDAC4 function. Hence, in this literature review, we aimed to debate documents pertaining to MB therapy with curcumin and other formulations in vitro and in vivo with a mechanistic insight.

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“…The Wnt/β-catenin signaling pathway is a complex and evolutionarily conserved signaling cascade that plays crucial roles in cellular development, proliferation, apoptosis, and other physiological processes, thereby exerting profound effects on fundamental biological functions ( 195 , 196 ). The Wnt protein binds to the Frizzled receptor on the cell membrane surface, forming the Wnt-Frizzled complex and inducing conformational changes ( 197 ).…”

Section: Critical Signaling Pathways Related To Tils In Hccmentioning

confidence: 99%

Key oncogenic signaling pathways affecting tumor-infiltrating lymphocytes infiltration in hepatocellular carcinoma: basic principles and recent advances

Wang,

Yuan,

et al. 2024

Front. Immunol.

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The incidence of hepatocellular carcinoma (HCC) ranks first among primary liver cancers, and its mortality rate exhibits a consistent annual increase. The treatment of HCC has witnessed a significant surge in recent years, with the emergence of targeted immune therapy as an adjunct to early surgical resection. Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has shown promising results in other types of solid tumors. This article aims to provide a comprehensive overview of the intricate interactions between different types of TILs and their impact on HCC, elucidate strategies for targeting neoantigens through TILs, and address the challenges encountered in TIL therapies along with potential solutions. Furthermore, this article specifically examines the impact of oncogenic signaling pathways activation within the HCC tumor microenvironment on the infiltration dynamics of TILs. Additionally, a concise overview is provided regarding TIL preparation techniques and an update on clinical trials investigating TIL-based immunotherapy in solid tumors.

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Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy

Cited by 23 publications

References 101 publications

Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway

Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway

Protective Effects of Curcumin Against Medulloblastoma: A Review

Key oncogenic signaling pathways affecting tumor-infiltrating lymphocytes infiltration in hepatocellular carcinoma: basic principles and recent advances

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