2006
DOI: 10.1210/jc.2005-1381
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Wnt/β-Catenin Signaling Mediates Antineoplastic Effects of Imatinib Mesylate (Gleevec) in Anaplastic Thyroid Cancer

Abstract: Our data provide a molecular mechanism for the antitumor activity of imatinib that may help to develop it as a therapeutic option in a subset of ATC patients.

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Cited by 37 publications
(18 citation statements)
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“…Immunoblotting with c-Abl antibody revealed the presence of c-Abl protein in immunoprecipitated mixture as well as in immunoprecipitates with ß-catenin and TCF-4 antibody. ß-catenin and TCF-4 were used as positive control because their interactions with c-Abl have been established earlier [25, 26]. c-Abl was also found in immunoprecipitates from cells treated with lactose indicating that this interaction is not dependent on galectin’s carbohydrate-binding properties.…”
Section: Resultsmentioning
confidence: 93%
“…Immunoblotting with c-Abl antibody revealed the presence of c-Abl protein in immunoprecipitated mixture as well as in immunoprecipitates with ß-catenin and TCF-4 antibody. ß-catenin and TCF-4 were used as positive control because their interactions with c-Abl have been established earlier [25, 26]. c-Abl was also found in immunoprecipitates from cells treated with lactose indicating that this interaction is not dependent on galectin’s carbohydrate-binding properties.…”
Section: Resultsmentioning
confidence: 93%
“…Imatinib inhibited phosphorylation of c-ABL1, increased p21, decreased several cyclins, and increased cells in S phase (Podtcheko et al 2003) and also inhibited growth and induced apoptosis (Kurebayashi et al 2006). Reduced cell proliferation and the downstream Wnt/catenin (cadherin-associated protein), beta 1 pathway has been observed (Rao et al 2006). However, the drug may not achieve its effects at clinically achievable concentrations (Dziba & Ain 2004).…”
Section: Preclinical Studiesmentioning
confidence: 99%
“…Imatinib mesylate inhibits tyrosine-phosphorylation of β-catenin (75), which may be one of the mechanisms for the chemopreventive effect of imatinib mesylate. However, imatinib mesylate has been reported to inhibit the Wnt/ β-catenin signaling in human colon cancer cell lines and thyroid carcinoma cell lines, suggesting that this chemical is also able to modulate the Wnt / β-catenin signaling (75).…”
Section: -3 Imatinib Mesylate and Othersmentioning
confidence: 99%