Wnt Signaling Network in Homo Sapiens

Nalbantoglu, Bahar; Tekir, Saliha Durmuş; Ülgen, Kutlu Ö.

doi:10.5772/26792

Cited by 5 publications

(10 citation statements)

References 75 publications

(42 reference statements)

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“…Cellular polarity is mediated by the commencement of c-Jun N-terminal kinase (JNK) signaling cascade through triggered Rac. DvL mediated activation of Wnt signaling induces the launch of heterotrimeric G protein which promotes cellular export of calcium to extracellular environment (Katoh and Katoh, 2007;Nalbantoglu et al, 2011). This transportation activates several kinases which include JNK, nemo like Kinase (NLK) and nuclear factor of activated T-cell (NFAT) through activation of calcium responsive kinase C and calcium/calmodulin-dependent Kinase II (CaMKII) (Anastas and Moon, 2013).…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

“…On the other hand, non-canonical signaling mediates the activation of canonical Wnt signaling through phosphorylation of T-cell factor (TCF) via NLK (Katoh and Katoh, 2007;Rao and Kühl, 2010). This indicates that both canonical and non-canonical signaling are antagonized one each other and calcium modulates such counteract by either activation of one the signaling (Nalbantoglu et al, 2011)…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

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Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Javed

Farooq

Ullah

et al. 2019

Asian Pac J Cancer Prev

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Cellular maintenance and development are two fundamental mechanisms regulated by the canonical Wnt signaling pathway. Wnt/beta-catenin signaling pathway controls a myriad of cellular processes that are essential for normal cell functioning. Cell cycle progression, differentiation, fate determination, and migration are generally orchestrated by canonical Wnt signaling. Altered Wnt/beta-catenin signaling has been considered a promoting event for different types of cancers and the oncogenic potential of Wnt signaling have been discussed in many cancer types, including breast, colon, pancreatic as well as head and neck. Furthermore, Wnt signaling is critical for the maintenance and stemness of both the normal as well as cancer stem cells. This review sheds new light on Wnt signaling and explains how it can regulate normal physiological processes and curtail the development of cancer. It depicts the vital functions of Wnt signaling in the stem cell growth and differentiation by focusing on current druggable targets that have been ascribed by recent studies. Thus, Wnt signaling pathway retains a tremendous potential in eradicating head and neck squamous cell carcinoma.

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Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Javed

Farooq

Ullah

et al. 2019

Asian Pac J Cancer Prev

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“…Wnt signaling pathway is an important mechanism for embryonic development and homeostasis of mature tissues ( MacDonald et al, 2009 ; Takahashi-Yanaga and Kahn, 2010 ; Nalbantoglu et al, 2011 ; Noguti et al, 2012 ; Novellasdemunt et al, 2015 ). It plays a vital role in controlling cell proliferation, differentiation, apoptosis, polarity, and migration ( Kléber and Sommer, 2004 ; Katoh and Katoh, 2007 ; Vlad et al, 2008 ; MacDonald et al, 2009 ; Takahashi-Yanaga and Kahn, 2010 ; Nalbantoglu et al, 2011 ; Noguti et al, 2012 ). Wnt signaling pathway can be divided into two, namely canonical and non-canonical pathways.…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

“…The Dvl-dependent signaling cascades include Rho family GTPases (such as RhoA and Rac) and c-jun N-terminal kinase (JNK) signaling cascades. RhoA activation is important for regulation of cytoskeletal rearrangements while activation of c-jun N-terminal kinase (JNK) signaling cascades through activated Rac is implicated in cell polarity control ( Katoh and Katoh, 2007 ; Nalbantoglu et al, 2011 ). On the other hand, the calcium-mediated Wnt pathway involves the activation of heterotrimeric G-proteins upon Wnt binding to Fzd ( Rao and Kühl, 2010 ).…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

“…On the other hand, the calcium-mediated Wnt pathway involves the activation of heterotrimeric G-proteins upon Wnt binding to Fzd ( Rao and Kühl, 2010 ). This will in turn activate phospholipase C (PLC), an important enzyme which promotes intracellular calcium release ( Nalbantoglu et al, 2011 ). The increase in calcium level results in the activation of several signaling cascades such as JNK, nemo-like kinase (NLK) and nuclear factor of activated T (NFAT) cascades through calcium-responsive proteins including protein kinase C, calcium/calmodulin-dependent kinase II (CaMKII) and/or calcineurin ( Rao and Kühl, 2010 ; Nalbantoglu et al, 2011 ; Anastas and Moon, 2013 ).…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

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Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling

Aminuddin

2016

Front. Pharmacol.

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Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. Furthermore, the canonical Wnt signaling pathway has also been described as one of the critical signaling pathways for regulation of normal stem cells as well as cancer cells with stem cell-like features, termed cancer stem cells (CSC). In this review, we will briefly describe the basic mechanisms of Wnt signaling pathway and its crucial roles in the normal regulation of cellular processes as well as in the development of cancer. Next, we will highlight the roles of canonical Wnt signaling pathway in the regulation of CSC properties namely self-renewal, differentiation, metastasis, and drug resistance abilities, particularly in head and neck squamous cell carcinoma. Finally, we will examine the findings of several recent studies which explore druggable targets in the canonical Wnt signaling pathway which could be valuable to improve the treatment outcome for head and neck cancer.

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Circadian clock crosstalks with autism

Yurdakul,

Barlas,

Ulgen

2023

Brain and Behavior

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BackgroundThe mechanism underlying autism spectrum disorder (ASD) remains incompletely understood, but researchers have identified over a thousand genes involved in complex interactions within the brain, nervous, and immune systems, particularly during the mechanism of brain development. Various contributory environmental effects including circadian rhythm have also been studied in ASD. Thus, capturing the global picture of the ASD‐clock network in combined form is critical.MethodsWe reconstructed the protein–protein interaction network of ASD and circadian rhythm to understand the connection between autism and the circadian clock. A graph theoretical study is undertaken to evaluate whether the network attributes are biologically realistic. The gene ontology enrichment analyses provide information about the most important biological processes.ResultsThis study takes a fresh look at metabolic mechanisms and the identification of potential key proteins/pathways (ribosome biogenesis, oxidative stress, insulin/IGF pathway, Wnt pathway, and mTOR pathway), as well as the effects of specific conditions (such as maternal stress or disruption of circadian rhythm) on the development of ASD due to environmental factors.ConclusionUnderstanding the relationship between circadian rhythm and ASD provides insight into the involvement of these essential pathways in the pathogenesis/etiology of ASD, as well as potential early intervention options and chronotherapeutic strategies for treating or preventing the neurodevelopmental disorder.

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Wnt Signaling Network in Homo Sapiens

Cited by 5 publications

References 75 publications

Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling

Circadian clock crosstalks with autism

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