Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

Abstract

Objective. To determine whether serum levels of 2 Wnt signaling antagonists, Frizzled-related protein (FRP) and Dkk-1, are associated with the development and progression of radiographic hip osteoarthritis (RHOA).Methods. Pelvic radiographs were obtained a mean of 8.3 years apart in 5,928 Caucasian women >65 years of age who were enrolled in the Study of Osteoporotic Fractures. Random sampling of this cohort was performed, with ϳ180 subjects per group assigned to 2 nested case-control studies on RHOA incidence and progression. Baseline serum levels of FRP and Dkk-1 were measured by capture enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression analyses with adjustment for potential covariates.Results. There were no differences in serum levels of FRP and Dkk-1 between case subjects with incidence or progression of RHOA and their respective control subjects. There was a trend for higher baseline serum levels of FRP to be associated with a reduced risk of incident RHOA ( Conclusion. Elevated circulating levels of Dkk-1 appeared to be associated with reduced progression of RHOA in elderly women, whereas the highest quartile of serum FRP levels tended to be associated with a modest reduction in risk of incident RHOA.

Dkk‐1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

“…However, its function in OA cartilage destruction is a subject of controversy. For instance, a cohort study suggested a positive correlation between serum levels of Dkk-1 and reduced progression of radiographic hip OA (15,16). In addition, investigators in another study reported that circulating Dkk-1 levels In B and D, ‫ء‬ ϭ P ϭ 0.05; ‫ءء‬ ϭ P ϭ 0.005; ‫ءءء‬ ϭ P ϭ 0.0001, by analysis of variance followed by post hoc test.…”

“…For example, cohort studies indicated that high serum levels of Dkk-1 were associated with reduced progression of radiographic hip OA (15,16). Additionally, a recent study by Honsawek et al (17) indicated that plasma and synovial fluid levels of Dkk-1 were markedly lower in the knees of OA patients than in those of healthy controls, suggesting that circulating Dkk-1 levels were inversely correlated with radiographic OA severity.…”

Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy

“…It is reported that alterations of circulating DKK-1 protein levels have been shown to be associated with various diseases such as multiple myeloma, rheumatoid arthritis, breast cancer, lung cancer, and esophageal cancer patients. [12][13][14][15][16] However, there is no documented study to associate circulating DKK-1 levels with DR. There is also no information available concerning the DKK-1 level in the vitreous fluid.…”

“…11 DKK-1 is a secreted protein and readily detectable in the circulation. [12][13][14][15][16] Therefore, it is hypothesized that DKK-1 levels in circulation or ocular fluid could be associated with the development and progression of DR.…”

What Is the Utility of Biomarkers for Assessing the Pathophysiology of Hip Osteoarthritis? A Systematic Review

“…Eleven ''progression'' studies [7-9, 15, 17, 24, 29, 30, 35, 37, 39] investigated the association of 13 different biomarker levels with the progression of hip OA. Of the 11 studies, four looked at progression of known hip OA [9,15,37,39]; three studies investigated the progression to incident hip OA from unspecified prearthritic hip disease [8,17,29]; and four studies investigated both OA progression and incidence [7,24,30,35]. Duration of followup to evaluate OA progression ranged from 1 year to 15 years.…”