Wnt/planar cell polarity signaling

Barrow, Jeffery R.

doi:10.4161/org.7.4.19049

Cited by 12 publications

(3 citation statements)

References 62 publications

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“…One possibility is that the reduced size is due to an inhibition of proliferation, as Dlgh-1 has been associated with regulating proliferation [22]. However, Wnt/PCP also has been shown to play a role in limb development [69], [70]. Wnt5a mutant mice exhibit truncated limbs [67] and the directional outgrowth of the limb has been shown to require Wnt5a/JNK signaling in the distal mesenchyme [71], [72].…”

Section: Discussionmentioning

confidence: 99%

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development

et al. 2013

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The development of specialized organs is tightly linked to the regulation of cell growth, orientation, migration and adhesion during embryogenesis. In addition, the directed movements of cells and their orientation within the plane of a tissue, termed planar cell polarity (PCP), appear to be crucial for the proper formation of the body plan. In Drosophila embryogenesis, Discs large (dlg) plays a critical role in apical-basal cell polarity, cell adhesion and cell proliferation. Craniofacial defects in mice carrying an insertional mutation in Dlgh-1 suggest that Dlgh-1 is required for vertebrate development. To determine what roles Dlgh-1 plays in vertebrate development, we generated mice carrying a null mutation in Dlgh-1. We found that deletion of Dlgh-1 caused open eyelids, open neural tube, and misorientation of cochlear hair cell stereociliary bundles, indicative of defects in planar cell polarity (PCP). Deletion of Dlgh-1 also caused skeletal defects throughout the embryo. These findings identify novel roles for Dlgh-1 in vertebrates that differ from its well-characterized roles in invertebrates and suggest that the Dlgh-1 null mouse may be a useful animal model to study certain human congenital birth defects.

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Section: Discussionmentioning

confidence: 99%

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development

et al. 2013

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“…Additionally, b-catenin can be stabilized by Wnt-independent mechanisms, such as planar cell polarity and the Wnt/Ca 2? pathway [26,27].…”

Section: Wnt/b-catenin Signaling Pathwaymentioning

confidence: 98%

The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?

Huang

Zhou

et al. 2015

Neurochem Res

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Temporal lobe epilepsy is one of the most common clinical neurological disorders. One of the major pathological findings in temporal lobe epilepsy is hippocampal sclerosis, characterized by massive neuronal loss and severe gliosis. The epileptogenesis process of temporal lobe epilepsy usually starts with initial precipitating insults, followed by neurodegeneration, abnormal hippocampus circuitry reorganization, and the formation of hypersynchronicity. Experimental and clinical evidence strongly suggests that dysfunctional neurogenesis is involved in the epileptogenesis. Recent data demonstrate that neurogenesis is induced by acute seizures or precipitating insults, whereas the capacity of neuronal recruitment and proliferation substantially decreases in the chronic phase of epilepsy. Participation of the Wnt/β-catenin signaling pathway in neurogenesis reveals its importance in epileptogenesis; its dysfunction contributes to the structural and functional abnormality of temporal lobe epilepsy, while rescuing this pathway exerts neuroprotective effects. Here, we summarize data supporting the involvement of Wnt/β-catenin signaling in the epileptogenesis of temporal lobe epilepsy. We also propose that the Wnt/β-catenin signaling pathway may serve as a promising therapeutic target for temporal lobe epilepsy treatment.

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“…Planar cell polarity (PCP) is a highly conserved intracellular mechanism used to generate concordant orientation of structures such as the Drosophila wing and eye (Maung and Jenny, 2011), the mammalian kidney (Carroll and Das, 2011), the vertebrate limb (Barrow, 2011), and the lung (Yates and Dean, 2011), among others. To establish intracellular asymmetries, the apical and basal surfaces of the cell are first distinguished by a set of proteins that are preferentially expressed on only one surface (Tree et al, 2002).…”

Section: Transducing Cytoplasmic Chirality Into Multi-cellular Asymmetrymentioning

confidence: 99%

A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

Vandenberg

Levin

2013

Developmental Biology

144

173

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Understanding how and when the left-right (LR) axis is first established is a fundamental question in developmental biology. A popular model is that the LR axis is established relatively late in embryogenesis, due to the movement of motile cilia and the resultant directed fluid flow during late gastrulation/early neurulation. Yet, a large body of evidence suggests that biophysical, molecular, and bioelectrical asymmetries exist much earlier in development, some as early as the first cell cleavage after fertilization. Alternative models of LR asymmetry have been proposed that accommodate these data, postulating that asymmetry is established due to a chiral cytoskeleton and/or the asymmetric segregation of chromatids. There are some similarities, and many differences, in how these various models postulate the origin and timing of symmetry breaking and amplification, and these events’ linkage to the well-conserved subsequent asymmetric transcriptional cascades. This review examines experimental data that lend strong support to an early origin of LR asymmetry, yet are also consistent with later roles for cilia in the amplification of LR pathways. In this way, we propose that the various models of asymmetry can be unified: early events are needed to initiate LR asymmetry, and later events could be utilized by some species to maintain LR-biases. We also present an alternative hypothesis, which proposes that individual embryos stochastically choose one of several possible pathways with which to establish their LR axis. These two hypotheses are both tractable in appropriate model species; testing them to resolve open questions in the field of LR patterning will reveal interesting new biology of wide relevance to developmental, cell, and evolutionary biology.

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Wnt/planar cell polarity signaling

Cited by 12 publications

References 62 publications

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development

The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?

A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

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