Wnt pathway markers in molecular subgroups of glioblastoma

Tompa, Márton; Nagy, Arnold; Komoly, Sámuel; Kálmán, Bernadette

doi:10.1016/j.brainres.2019.05.008

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…This results corroborated with several recent studies. Tompa’s team found that FZD2 was highly expressed in all GBM subgroups ( Tompa et al, 2019 ). Ádám et al found that FZD2 expression was positively correlated with the glioma grade ( Ádám et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of therapeutic targets and prognostic biomarkers among frizzled family genes in glioma

Huang

Han

et al. 2023

Front. Mol. Biosci.

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Background: The biological functions of the Frizzled gene family (FZDs), as the key node of wingless-type MMTV integration site family (Wnt) and mammalian target of rapamycin signaling pathways, have not been fully elucidated in glioma. This study aims to identify novel therapeutic targets and prognostic biomarkers for gliomas, which may help us understand the role of FZDs.Methods: RNA-sequence data were downloaded from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) projects. Survival analyses, Cox regression analyses, nomograms, calibration curves, receiver operating characteristic (ROC) curves, gene function enrichment analyses, and immune cell infiltration analyses were conducted using R.Results: High expressions of FZDs were positively associated with the activation of mTOR signaling. FZD1/2/3/4/5/7/8 was significantly highly expressed in tumor tissues, and the high expression of FZD1/2/5/6/7/8 was significantly positively associated with poorer prognosis. FZD2 and FZD6 positively served as independent predictors of poor prognosis. Gene function analysis showed that FZDs were associated with mTOR signaling, immune response, cytokine-cytokine receptor interaction, extracellular matrix organization, apoptosis, and p53 signaling pathway.Conclusions: Our finding strongly indicated a crucial role of FZDs in glioma. FZD1/2/5/6/7/8 could be an unfavorable prognostic factor in glioma and FZD2 and FZD6 may be novel independent predictors of poor prognosis in glioma.

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Section: Discussionmentioning

confidence: 99%

Identification of therapeutic targets and prognostic biomarkers among frizzled family genes in glioma

Huang

Han

et al. 2023

Front. Mol. Biosci.

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“…The Wnt pathway is very much involved in EMT, thus participating in glioma plasticity and migration [133]. Malfunctioning of Wnt pathway was noted in the formation and maintenance of GSCs [134][135][136]. Not only ligands and receptors, but also negative and positive regulators of Wnt signaling were overexpressed, and controlled EMT and tumor microenvironment communication [137,138].…”

Section: Signaling Pathways In Glioma Cancer Stem Cellsmentioning

confidence: 99%

Glioma Stem Cells—Features for New Therapy Design

Pećina-Šlaus,

Hrašćan

2024

Cancers

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On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cells that behave like stem cells and are known as glioma cancer stem cells (GCSCs). They are responsible for tumor plasticity and are influenced by genetic drivers. Additionally, GCSCs also display greater migratory abilities. A great effort is under way in order to find ways to eliminate or neutralize GCSCs. Many different treatment strategies are currently being explored, including modulation of the tumor microenvironment, posttranscriptional regulation, epigenetic modulation and immunotherapy.

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“…The TCF7L2 gene product is a transcription factor containing a high mobility group cassette that plays an essential role in the Wnt signaling pathway ( Su et al, 2015 ; Torres-Aguila et al, 2022 ). The Wnt signaling pathway has been shown to play an important role in the progression of glioma by affecting the differentiation, proliferation, migration, and apoptosis of neural cells ( Tompa et al, 2019 ; Pei et al, 2022 ). Recent studies have shown the presence of glioma stem cells in GBM ( Ma et al, 2020 ).…”

Section: Vti1a and Neurological Disordersmentioning

confidence: 99%

The Role of Vti1a in Biological Functions and Its Possible Role in Nervous System Disorders

Tang

Fan

Zhang

et al. 2022

Front. Mol. Neurosci.

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Vesicle transport through interaction with t-SNAREs 1A (Vti1a), a member of the N-ethylmaleimide-sensitive factor attachment protein receptor protein family, is involved in cell signaling as a vesicular protein and mediates vesicle trafficking. Vti1a appears to have specific roles in neurons, primarily by regulating upstream neurosecretory events that mediate exocytotic proteins and the availability of secretory organelles, as well as regulating spontaneous synaptic transmission and postsynaptic efficacy to control neurosecretion. Vti1a also has essential roles in neural development, autophagy, and unconventional extracellular transport of neurons. Studies have shown that Vti1a dysfunction plays critical roles in pathological mechanisms of Hepatic encephalopathy by influencing spontaneous neurotransmission. It also may have an unknown role in amyotrophic lateral sclerosis. A VTI1A variant is associated with the risk of glioma, and the fusion product of the VTI1A gene and the adjacent TCF7L2 gene is involved in glioma development. This review summarizes Vti1a functions in neurons and highlights the role of Vti1a in the several nervous system disorders.

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Wnt pathway markers in molecular subgroups of glioblastoma

Cited by 7 publications

References 39 publications

Identification of therapeutic targets and prognostic biomarkers among frizzled family genes in glioma

Identification of therapeutic targets and prognostic biomarkers among frizzled family genes in glioma

Glioma Stem Cells—Features for New Therapy Design

The Role of Vti1a in Biological Functions and Its Possible Role in Nervous System Disorders

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