Wnt-Frizzled planar cell polarity signaling in the regulation of cell motility

Koca, Yildiz; Collu, Giovanna M.; Mlodzik, Marek

doi:10.1016/bs.ctdb.2022.03.006

Cited by 24 publications

(18 citation statements)

References 181 publications

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“…To align the orientation of cells along the tissue axis, factors that transmit information regarding tissue orientation are necessary. Such factors are referred to as global factors, which include a gradient of extracellular concentration of WNT molecules [ 44 , 45 , 46 ], differences in the level of expression of atypical cadherins Dachsous/Fat and their modulator Four-jointed [ 23 , 25 , 47 , 48 , 49 , 50 ], forces exerted on epithelial tissues [ 51 , 52 , 53 , 54 ], and fluid flow [ 37 , 55 ]. Those global cues somehow control the localization of core PCP proteins at cell boundaries.…”

Section: Roles Of Core Pcp Proteins In Coordinating Cilia Orientationmentioning

confidence: 99%

Coordination of Cilia Movements in Multi-Ciliated Cells

Arata

Usami

Fujimori

2022

JDB

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Multiple motile cilia are formed at the apical surface of multi-ciliated cells in the epithelium of the oviduct or the fallopian tube, the trachea, and the ventricle of the brain. Those cilia beat unidirectionally along the tissue axis, and this provides a driving force for directed movements of ovulated oocytes, mucus, and cerebrospinal fluid in each of these organs. Furthermore, cilia movements show temporal coordination between neighboring cilia. To establish such coordination of cilia movements, cilia need to sense and respond to various cues, including the organ’s orientation and movements of neighboring cilia. In this review, we discuss the mechanisms by which cilia movements of multi-ciliated cells are coordinated, focusing on planar cell polarity and the cytoskeleton, and highlight open questions for future research.

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Section: Roles Of Core Pcp Proteins In Coordinating Cilia Orientationmentioning

confidence: 99%

Coordination of Cilia Movements in Multi-Ciliated Cells

Arata

Usami

Fujimori

2022

JDB

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“…The Wnt/PCP pathway functions in a wide variety of morphogenetic processes and instructs cells with positional cues for directed movements [17]. Particularly, Wnt/PCP signaling is required for cell intercalations during gastrulation, neurulation, and asymmetric organogenesis [6,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure

Shi

2022

Cell. Mol. Life Sci.

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Gastrulation and neurulation are successive morphogenetic processes that play key roles in shaping the basic embryonic body plan. Importantly, they operate through common cellular and molecular mechanisms to set up the three spatially organized germ layers and to close the neural tube. During gastrulation and neurulation, convergent extension movements driven by cell intercalation and oriented cell division generate major forces to narrow the germ layers along the mediolateral axis and elongate the embryo in the anteroposterior direction. Apical constriction also makes an important contribution to promote the formation of the blastopore and the bending of the neural plate. Planar cell polarity proteins are major regulators of asymmetric cell behaviors and critically involved in a wide variety of developmental processes, from gastrulation and neurulation to organogenesis. Mutations of planar cell polarity genes can lead to general defects in the morphogenesis of different organs and the co-existence of distinct congenital diseases, such as spina bifida, hearing deficits, kidney diseases, and limb elongation defects. This review outlines our current understanding of non-canonical Wnt signaling, commonly known as Wnt/planar cell polarity signaling, in regulating morphogenetic movements of gastrulation and neural tube closure during development and disease. It also attempts to identify unanswered questions that deserve further investigations.

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“…reviewed in (Adler, 2012; Axelrod, 2020; Butler and Wallingford, 2017; Devenport, 2014; Goodrich and Strutt, 2011; Humphries and Mlodzik, 2018; Yang and Mlodzik, 2015)). Although PCP was initially discovered in epithelia, the cellular mechanisms controlling PCP are detected in many other cell types, including migratory mesenchymal cells or migratory neurons (reviewed in (Davey and Moens, 2017; Devenport, 2014; Koca et al, 2022). PCP establishment is mainly governed by members of the conserved Wnt/Frizzled-PCP pathway, often referred to as the Core PCP pathway (reviewed in (Adler, 2012; Axelrod, 2020; Butler and Wallingford, 2017; Devenport, 2014; Goodrich and Strutt, 2011; Humphries and Mlodzik, 2018; Yang and Mlodzik, 2015))…”

Section: Introductionmentioning

confidence: 99%

“…The resulting final asymmetric localization is generated through a dynamic process, including unstable intermediary subcomplexes. The ‘terminal’ asymmetric core PCP complex localization then directs spatially restricted downstream signaling events through cell-type specific effectors, leading to - depending on the tissue - cytoskeletal rearrangement, centriole/centrosome/ciliary positioning, migratory regulation, and/or nuclear read-outs (reviewed in (Adler, 2012; Axelrod, 2020; Butler and Wallingford, 2017; Carvajal-Gonzalez et al, 2016; Davey and Moens, 2017; Devenport, 2014; Humphries and Mlodzik, 2018; Koca et al, 2022; Yang and Mlodzik, 2015)).…”

Section: Introductionmentioning

confidence: 99%

A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled

Humphries

Hazelett

Molina-Pelayo

et al. 2022

Preprint

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Epithelial tissues can be polarized along two axes, in addition to apical-basal polarity they are often also polarized within the plane of the epithelium, known as planar cell polarity (PCP). PCP depends upon the conserved Wnt/Frizzled (Fz) signaling factors, including Fz itself and Van Gogh (Vang/Vangl). Here, taking advantage of the complementary features of Drosophila wing and mouse skin PCP establishment, we dissect how Vang phosphorylation on a specific conserved tyrosine residue affects its interaction with two cytoplasmic core PCP factors, Dsh/Dvl and Pk. We demonstrate that Pk and Dsh/Dvl bind to Vang/Vangl in an overlapping region centered around this tyrosine. Strikingly, Vang/Vangl2 phosphorylation promotes its binding to Pk, a key effector of the Vang/Vangl complex, and inhibits its interaction with Dsh/Dvl, and thus phosphorylation of this tyrosine appears to promote the formation of the mature and stable Vang/Vangl-Pk complex during PCP establishment. Interestingly, as our single point mutations allow selective binding inhibition of either Dsh or Pk, we can demonstrate for the first time that Dsh interaction with Vang is physiologically important, as all single point mutations fail to rescue the Vang null mutant wing phenotype.

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Wnt-Frizzled planar cell polarity signaling in the regulation of cell motility

Cited by 24 publications

References 181 publications

Coordination of Cilia Movements in Multi-Ciliated Cells

Coordination of Cilia Movements in Multi-Ciliated Cells

Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure

A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled

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