Wnt and planar cell polarity signaling in cystic renal disease

Goggolidou, Paraskevi

doi:10.4161/org.26766

Cited by 47 publications

(51 citation statements)

References 102 publications

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“…One possibility is that, during kidney development, Wnt5 and Wnt11 participate in both Wnt/ -catenin and PCP signaling. Indeed several Wnt molecules, including Wnt5a, were reported to act in both Wnt pathways [114] but the particular Wnt pathway activation seems to depend on unknown tissue-specific factors [115]. Another possibility is that the activities of the canonical Wnt and the PCP pathways are interdependent.…”

Section: Planar Cell Polarity Pathway and Kidneymentioning

confidence: 99%

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Planar Cell Polarity Pathway in Kidney Development and Function

Rocque

Torban

2015

Advances in Nephrology

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The evolutionarily conserved planar cell polarity (PCP) signaling pathway controls tissue polarity within the plane orthogonal to the apical-basal axis. PCP was originally discovered in Drosophila melanogaster where it is required for the establishment of a uniform pattern of cell structures and appendages. In vertebrates, including mammals, the PCP pathway has been adapted to control various morphogenetic processes that are critical for tissue and organ development. These include convergent extension (crucial for neural tube closure and cochlear duct development) and oriented cell division (needed for tubular elongation), ciliary tilting that enables directional fluid flow, and other processes. Recently, strong evidence has emerged to implicate the PCP pathway in vertebrate kidney development. In this review, we will describe the experimental data revealing the role of PCP signaling in nephrogenesis and kidney disease.

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Section: Planar Cell Polarity Pathway and Kidneymentioning

confidence: 99%

“…This important work confirmed that the loss of OCD may contribute to cystogenesis. In subsequent years, numerous studies have examined the complex relationship between the PCP pathway, OCD, and cystogenesis [115,131,132].…”

Section: Advances In Nephrologymentioning

confidence: 99%

Planar Cell Polarity Pathway in Kidney Development and Function

Rocque

Torban

2015

Advances in Nephrology

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“…У Wnt-/PCP-шляху (справа) зв'язування Wnt-ліганду веде до активації Frizzled або Dishevelled з подальшою реорганізацією цитоскелету або ак-тивацією транскрипції через RhoA або Rac1. Ко-рові молекули (Vangl, Celsr, Scribble) важливі для Wnt-/PCP-сигнального шляху, тоді як ефекторні мо-лекули (Fuzzy, Fat4, Ptk7) -для нефрогенезу [7].…”

Section: Wnt-/β-êàòåí³í-ñèãíàëüíèé øëÿõunclassified

Циліопатії, роль Wnt-сигнального шляху в перебігу гострого (постінфекційного) гломерулонефриту: огляд літератури та власне спостереження

Diadyk¹,

Nekrasova²,

Ivanova³

2021

KIDNEYS

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Резюме. Первинні війки -це субклітинні органели, що є похідними цитоплазматичної мембрани клітин май- ÂñòóïПервинні війки -циліндричні органели, при-сутні на поверхні майже усіх клітин. Вони скла-даються з мікротрубочок, оточених клітинною мембраною [1]. Мікротрубочки прикріплені до базального тільця, що під час мітозу трансформу-ється в центріоль [2]. Первинні війки виконують свої функції шляхом сприйняття сигналів з поза-клітинного середовища: рух позаклітинної рідини згинає війки, що призводить до активації іонами Ca 2+ внутрішньоклітинних сигнальних каскадів (механосенсорна функція); також різноманітні рецептори, сприймаючи позаклітинні ліганди, пе-редають сигнал всередину клітини (хемосенсорна функція). Подальші молекулярні зміни всереди-ні клітини реалізуються завдяки Wnt, Hedgehog, Hippo, platelet-derived growth factor (PDGF) сиг-нальним шляхам [3].Оскільки первинні війки присутні на поверхні майже усіх клітин, їх дисфункції -циліопатії -мають різноманітні прояви, включаючи ураження нирок, головного мозку, сітківки. Циліопатії спри-чинені мутаціями генів, які кодують білки війок, призводять до порушення їх функції [4]. У нирках Адреса для листування з авторами: Дядик Олена Олександрівна

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“…Disturbances in PCP signaling produce developmental anomalies in neural tube closure, left-right asymmetry, and hair cell orientation in the inner ear (14)(15)(16)(17)(18)(19)(20). In humans, mutations or polymorphisms of PCP components are associated with an array of developmental defects including spina bifida, cardiac outflow malformations, and cystic renal disease (21)(22)(23)(24).…”

Section: Significancementioning

confidence: 99%

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation

Yuan

Cha

Deng

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo-uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown. Here we provide evidence that planar cell polarity (PCP) signaling orchestrates directed epithelial evaginations to form crypts for implantation in mice. Uterine deletion of Vang-like protein 2, but not Vang-like protein 1, conferred aberrant PCP signaling, misdirected epithelial evaginations, defective crypt formation, and blastocyst attachment, leading to severely compromised pregnancy outcomes. The study reveals a previously unrecognized role for PCP in executing spatial cues for crypt formation and implantation. Because PCP is an evolutionarily conserved phenomenon, our study is likely to inspire implantation studies of this signaling pathway in humans and other species.ffective reciprocal cross-talk between the receptive uterus and a competent blastocyst is critical for successful implantation (1). In nearly all mammals studied, the uterus differentiates into a receptive state timed appropriately with the migration of blastocysts into the uterus to initiate bidirectional communication for implantation. The receptive state is transient; in mice the uterus becomes receptive on day 4 of pregnancy (day 1 = vaginal plug) and refractory to implantation by the afternoon of day 5 (2). The coordinated actions of progesterone and estrogen regulate the proliferation and/or differentiation of major uterine cell types in a spatiotemporal manner to establish this brief window of receptivity for implantation. These changes involve an interplay of ovarian hormones, transcription factors, growth factors, morphogens, cytokines, and other signaling molecules. Aberrations or defects in any of these pathways may result in implantation failure or defective implantation, which propagates adverse ripple effects through the remaining course of gestation, compromising pregnancy outcomes (2-5).Blood vessels enter the uterus from the mesometrium and delineate the uterus into mesometrial (M) and antimesometrial (AM) domains. In mice, blastocyst attachment occurs within specialized crypts (implantation chambers), which originate as epithelial evaginations from the main lumen at orderly spaced intervals at the AM domain. The formation of these directed evaginations is initiated on the morning of day 3, and they elongate by the afternoon of day 4 for blastocyst attachment and subsequent crypt formation in the evening along the Wnt5a gradient (6). Blastocyst attachment coincides with increased endometrial vascular permeability at the site of the attachment, which can...

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Wnt and planar cell polarity signaling in cystic renal disease

Cited by 47 publications

References 102 publications

Planar Cell Polarity Pathway in Kidney Development and Function

Planar Cell Polarity Pathway in Kidney Development and Function

Циліопатії, роль Wnt-сигнального шляху в перебігу гострого (постінфекційного) гломерулонефриту: огляд літератури та власне спостереження

Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation

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