Wnt-1 has multiple effects on the expression of glutamate transporters

Jimenez, Amie L; Chou, Alice H; Khadadadi, Omid; Palos, Teresa P.; Howard, Bruce D.

doi:10.1016/s0197-0186(02)00099-2

Cited by 5 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to this report, it could not be excluded that the increases in glial glutamate transporter immunoreactivities may be morphological clues indicating the enhancement of reverse glutamate transport from glia (presumably in astrocytes), like neurons. This is because Na + ‐mediated hyperexcitability during ischaemic condition may be a plausible factor in the reverse transport of various neurotransmitters from glia and neurons (Vizi, 1972,1979; Vizi and Sperlagh, 1999; Kimmich et al., 2001; Miralles et al., 2001; Jimenez et al., 2003). Therefore, our findings suggest that reverse glutamate transport by glia may also play an important role in the elevation of extracellular glutamate concentration in the early ischaemic insults, and down‐regulation of glial glutamate transporter immunoreactivities may participate in excessive glutamate concentration during the late ischaemic insults.…”

Section: Discussionmentioning

confidence: 99%

Transient Ischaemia Affects Plasma Membrane Glutamate Transporter, not Vesicular Glutamate Transporter, Expressions in the Gerbil Hippocampus

Kim¹,

Kwak²,

Kim³

et al. 2006

Anat Histol Embryol

View full text Add to dashboard Cite

In the present study, we investigated expressions of vesicular glutamate transporter (VGLUT) and of the plasma membrane glutamate transporters [glutamate transporter 1 (GLT-1), glutamate/aspartate transporter (GLAST) and excitatory amino acid carrier 1 (EAAC-1)] in the gerbil hippocampus following transient ischaemia. The expressional levels and distribution patterns of VGLUT immunoreactivities were unaltered until 3 days after ischaemic-insults. However, VGLUT-2 immunoreactivity in the CA1 region was reduced at 4 days after ischaemia due to delayed neuronal death. In addition, both GLT-1 and GLAST immunoreactivities in the CA1 region were enhanced at 30 min - 12 h after ischaemia-reperfusion and their expression began to reduce at 24 h after ischaemia-reperfusion. In contrast, EAAC-1 immunoreactivity was transiently reduced in the CA1 region at 30 min after ischaemia, re-enhanced at 3-12 h after ischaemia, and re-reduced at 24 h after ischaemia. These findings suggest that malfunctions of plasma membrane glutamate transporters, not of VGLUT, may play an important role in the elevation of extracellular glutamate concentration following ischaemic insults.

show abstract

Section: Discussionmentioning

confidence: 99%

Transient Ischaemia Affects Plasma Membrane Glutamate Transporter, not Vesicular Glutamate Transporter, Expressions in the Gerbil Hippocampus

Kim¹,

Kwak²,

Kim³

et al. 2006

Anat Histol Embryol

View full text Add to dashboard Cite

show abstract

Glutamate transporters in the biology of malignant gliomas

Robert

Sontheimer

2013

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop many biological advantages that allow them to grow and survive in the unique environment of the brain. The glutamate transporters System xc− and Excitatory Amino Acid Transporters (EAAT) are emerging as key players in the biology and malignancy of these tumors. Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival. As a consequence, malignant cells are able to quickly destroy and invade surrounding normal brain. Recent findings are painting a larger picture of these transporters in glioma biology, and as such are providing opportunities for clinical intervention for patients. This review will detail the current understanding of glutamate transporters in the biology of malignant gliomas and highlight some of the unique aspects of these tumors that make them so devastating and difficult to treat.

show abstract

Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer

Freidman

Chen

et al. 2020

Neurochem Res

View full text Add to dashboard Cite

Wnt-1 has multiple effects on the expression of glutamate transporters

Cited by 5 publications

References 35 publications

Transient Ischaemia Affects Plasma Membrane Glutamate Transporter, not Vesicular Glutamate Transporter, Expressions in the Gerbil Hippocampus

Transient Ischaemia Affects Plasma Membrane Glutamate Transporter, not Vesicular Glutamate Transporter, Expressions in the Gerbil Hippocampus

Glutamate transporters in the biology of malignant gliomas

Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer

Contact Info

Product

Resources

About