Abstract:When challenged by hypertonicity, dehydrated cells recover their volume though regulatory volume increase (RVI). This process is thought to be initiated by an undefined intracellular sensing and transduction mechanism that responds to macromolecular crowding (Parker JC AJP 1993). In many cell types, RVI is mediated by the bumetanide‐sensitive cotransporter NKCC1, which is phosphorylated and activated by the WNK‐SPAK/OSR1 pathway. Reconciling the mechanism of hypertonic stress‐induced activation of NKCC1 has be… Show more
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