Within-subject biological variation of glucose and HbA1c in healthy persons and in type 1 diabetes patients

Abstract

In conclusion, we found a high within-subject biological variation of glucose in diabetes patients as expected compared to healthy individuals (30% vs. 5%). The short-term (2 months) within-subject biological variation of HbA(1c) did not differ significantly between well regulated type 1 diabetes patients and healthy individuals (1.7% vs. 1.2%).

Weekly and 90-Minute Biological Variations in Cardiac Troponin T and Cardiac Troponin I in Hemodialysis Patients and Healthy Controls

“…As suggested by Fraser and Harris (27 ), the variance homogeneity in the analytical and within-person variances were tested for each data series (log-transformed data; healthy individuals and HD patients for both assays) using the Cochran and Bartlett tests. Patients exhibiting nonhomogeneity were identified by plotting the cumulated fractions of the ranked individual variation results (consisting of both CVi and CVa) on a Rankin scale as a function of the within-person variation of hs cardiac troponin (1 curve per series), and patients or healthy individuals were excluded until homogeneity of variance was achieved (data not shown) (34 ). For hs-cTnT, homogeneity of variance was achieved in both series describing the 90-min variation without excluding any individual, although 1 healthy individual (number 5) and 1 HD patient (number 10) were excluded from the calculation of the weekly biological variation (see online Supplemental Table 1).…”

Biological Variation of Hemoglobin A1c: Consequences for Diagnosing Diabetes Mellitus

“…CVwp refers to an inherent biological variation around an individual patient's set point of a biological parameter. Several studies have been published assessing the CVwp of Hb A 1c (1)(2)(3). However, none of those studies used Ͼ1 Hb A 1c method to determine the CVwp.…”

A history of HbA1c through Clinical Chemistry and Laboratory Medicine

“…This is the case of troubles of iron metabolism [117,118] , e.g., in HIV infection [119] even in non-diabetic subjects [120] . In all occurrences, the importance of taking into account within-subject biological variations in both type 1 [121] and type 2 [122] diabetic patients and in non-diabetic subjects [123] for clinical interpretation was underlined.…”