Within-subject biological variation in disease: the case of tumour markers

Dittadi, Ruggero; Peloso, L.; Gion, Massimo

doi:10.1258/acb.2007.072441

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Furthermore, detailed examination of published data by Ricós and colleagues 16 suggests CV i in healthy and diseased states is mostly similar, except for tumor markers, creatinine, and glycated hemoglobin A1c. 17 Such comparison is not available for CV g .…”

Section: Discussionmentioning

confidence: 99%

Indirect Estimation of Pediatric Between-Individual Biological Variation Data for 22 Common Serum Biochemistries

Loh

Metz

2015

American Journal of Clinical Pathology

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Section: Discussionmentioning

confidence: 99%

Indirect Estimation of Pediatric Between-Individual Biological Variation Data for 22 Common Serum Biochemistries

Loh

Metz

2015

American Journal of Clinical Pathology

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“…Ricós, Dittadi and others found significant differences in biological variability for certain analytes, e.g., tumour markers, troponins, and HbA 1c [11,12]. Therefore, trials in patients are considered to be clinically useful experiments [12].…”

Section: Discussionmentioning

confidence: 99%

Long-term biological variability of galectin-3 after heart transplantation

Franeková¹,

Kubíček²,

Hošková³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…42 There are few data for serum Tg -within-subject variability in a group of healthy women has been reported to be 8.5% and 16.2% for TgAbs and Tg, respectively. 43 Thus there is little information to allow formal evaluation of critical differences or reference change values for serum Tg.…”

Section: Biological Variabilitymentioning

confidence: 99%

“…There is a significant literature on the biological variability of many analytes of clinical interest and recognition that the within-subject variability may differ in patients with disease as compared with healthy controls. 42 There are few data for serum Tg – within-subject variability in a group of healthy women has been reported to be 8.5% and 16.2% for TgAbs and Tg, respectively. 43 Thus there is little information to allow formal evaluation of critical differences or reference change values for serum Tg.…”

Section: Biological Variabilitymentioning

confidence: 99%

Can we interpret serum thyroglobulin results?

Clark

Franklyn

2012

Ann Clin Biochem

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Thyroglobulin (Tg) is a tumour marker for differentiated thyroid cancer. Interpretation requires a knowledge of the current thyrotropin (TSH) concentration as secretion is TSH-dependent. While a raised serum Tg may be indicative of residual or recurrent thyroid cancer, trauma to the thyroid (e.g. surgical, biopsy or due to radioiodine treatment) also causes an increase. Tg may be measured when TSH is suppressed and also following recombinant TSH (rhTSH) stimulation. Interpretation of results in pregnancy and in children is discussed. Assay bias and interference by endogenous Tg antibodies (Abs) are the main confounders in the interpretation of results. Although there is an international standard for Tg, there are large differences in results and yet there are few assay-specific clinical decision limits. Patients should therefore be monitored with the same assay. Endogenous TgAbs may cause false-negative interference in immunometric assays and may cause false-positive results in radioimmunoassay. Although the measurement of TgAbs has been advocated for predicting interference, it is now clear that interference can still occur when TgAbs have not been detected, the effect being TgAb-assay-specific. Approaches to identifying those samples where there may be interference are discussed. The laboratory should have a protocol for the investigation of possible interferences and data on the bias of the Tg assay that they use. An appreciation of the clinical uses of the service is required as an understanding by endocrinologists, oncologists and endocrine surgeons of the analytical limitations of the service.

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Within-subject biological variation in disease: the case of tumour markers

Cited by 8 publications

References 8 publications

Indirect Estimation of Pediatric Between-Individual Biological Variation Data for 22 Common Serum Biochemistries

Indirect Estimation of Pediatric Between-Individual Biological Variation Data for 22 Common Serum Biochemistries

Long-term biological variability of galectin-3 after heart transplantation

Can we interpret serum thyroglobulin results?

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