Within-Session Practice Effects in Patients Referred for Suspected Dementia

Duff, Kevin; Chelune, Gordon J.; Dennett, Kathryn

doi:10.1159/000339268

Cited by 31 publications

(33 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the decline in the HT discontinuation group was less than one standard deviation and likely clinically insignificant, it suggests a loss of expected practice effects. The loss of practice effects has been shown to differentiate between cognitively normal adults, adults with mild cognitive impairment, and dementia over short- and long-term retesting with greater loss being associated with MCI and dementia 28-30 . All women remained cognitively normal but the loss of these practice effects in the HT discontinuation group suggests early cognitive changes that may not be clinically apparent.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Effects of Hormone Therapy Continuation or Discontinuation in a Sample of Women at Risk for Alzheimer Disease

Wroolie

Kenna

Williams

et al. 2015

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

Use of estrogen-based hormone therapy (HT), as a protection from cognitive decline and Alzheimer’s disease, is controversial although cumulative data supports HT use when initiated close to menopause onset with estrogen formulations containing 17β-estradiol (17β-E) being preferable to conjugated equine estrogen formulations. Little is known regarding specific populations of women who may derive benefit from HT. Women with heightened risk for AD (aged 49-69), all of whom were taking HT for at least one year, most of whom initiated HT close to menopause onset, underwent cognitive assessment followed by randomization to continue or discontinue HT. Assessments were repeated at two years after randomization. Women who continued HT performed better on cognitive domains composed of measures of verbal memory, and combined attention, working memory, and processing speed measures. Women who used 17β-E versus conjugated equine estrogen, whether randomized to continue or discontinue HT showed better verbal memory performance at the 2-year follow-up assessment. An interaction was also found with HT randomization and family history of AD in a first degree relative. All women offspring of patients with AD declined in verbal memory however, women who continued HT declined less than women who discontinued HT. Women without a first-degree relative with AD showed verbal memory improvement (likely due to practice effects) with continuance and declined with discontinuance of HT. Continuation of HT use appears to protect cognition in women with heightened risk for AD when initiated close to menopause onset.

show abstract

Section: Discussionmentioning

confidence: 99%

Cognitive Effects of Hormone Therapy Continuation or Discontinuation in a Sample of Women at Risk for Alzheimer Disease

Wroolie

Kenna

Williams

et al. 2015

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

show abstract

“…Third, this enrichment strategy may be most useful in older adults who are cognitively intact or have early MCI, and it is unclear if would be as helpful in cases of late MCI or early AD. We have been experimenting with shorter retest intervals (e.g., within the same session) 38 , and these may be more beneficial in patients with more advanced disease. Fourth, it is not clear that practice effects on the BVMT-R would be as useful in predicting amyloid positivity using other radioligands (e.g., 11 C-Pittsburgh compound, other 18 F agents).…”

Section: Discussionmentioning

confidence: 99%

Practice Effects and Amyloid Deposition

Duff

Foster

Hoffman

2014

Alzheimer Disease &Amp; Associated Disorders

Self Cite

View full text Add to dashboard Cite

Clinical trials in Alzheimer’s disease are moving towards prevention studies in prodromal individuals with amyloid burden. However, methods are needed to identify individuals expected to be amyloid positive for these studies to be feasible and cost effective. The current study sought to determine whether short-term practice effects on cognitive tests can identify those with notable uptake on amyloid imaging. Twenty-five, non-demented older adults (15 cognitively intact, 10 Mild Cognitive Impairment) underwent amyloid imaging via 18F-flutemetamol and two cognitive testing sessions across one week to determine practice effects on a visual memory test. Results indicated that whereas 18F-flutemetamol uptake showed little association with baseline performance on a visual memory test (r=−0.04, p=0.85), it was significantly correlated with practice effects across one week on that same memory measure (r=−0.45, p=0.02), with greater uptake being associated with lower practice effects. The odds ratio of notable 18F-flutemetamol uptake was 5 times higher in individuals with low practice effects compared to high practice effects. Although these preliminary results need to be replicated in larger samples, short-term practice effects on cognitive tests may provide an affordable screening method to identify individuals who are amyloid positive, which could enrich samples for preventative clinical trials in Alzheimer’s disease.

show abstract

“…Similar measures (e.g. simple difference scores and ratios) have been used previously to document practice effects on other cognitive assessments (Duff, 2014; Duff et al, 2008; Duff, Chelune, & Dennett, 2012). These measures of practice effects were calculated once we evaluated test-retest correlations and confirmed significant differences between baseline and these trials of interests (see “Statistical analyses” below).…”

Section: Methodsmentioning

confidence: 99%

Within-session and one-week practice effects on a motor task in amnestic mild cognitive impairment

Schaefer

Duff

2016

Journal of Clinical and Experimental Neuropsychology

Self Cite

View full text Add to dashboard Cite

Practice effects on neuropsychological tests, which are improvements in test scores due to repeated exposure to testing materials, are robust in healthy elders, but muted in older adults with cognitive disorders. Conversely, few studies have investigated practice effects on motor tasks involving procedural memory, particularly across test-retest periods exceeding 24 hours. The current study examined one-week practice effects on a novel upper extremity motor task in 54 older adults with amnestic Mild Cognitive Impairment. Results indicate that these individuals with primary memory deficits did improve on this motor task within a brief training session as well as across one week. These practice effects were unrelated to demographic characteristics or global cognition. One-week practice effects were, however, negatively related to delayed memory function, with larger practice effects being associated with poorer delayed memory and potentially better visuospatial ability. The presence of longer-term practice effects on a procedural motor task not only has implications for how longitudinal assessments with similar measures involving implicit memory might be interpreted, but may also inform future rehabilitative strategies for patients with more severe declarative memory deficits.

show abstract

Within-Session Practice Effects in Patients Referred for Suspected Dementia

Cited by 31 publications

References 25 publications

Cognitive Effects of Hormone Therapy Continuation or Discontinuation in a Sample of Women at Risk for Alzheimer Disease

Cognitive Effects of Hormone Therapy Continuation or Discontinuation in a Sample of Women at Risk for Alzheimer Disease

Practice Effects and Amyloid Deposition

Within-session and one-week practice effects on a motor task in amnestic mild cognitive impairment

Contact Info

Product

Resources

About