Within-laboratory and between-laboratory variability in the measurement of anti-müllerian hormone determined within an external quality assurance scheme

Zuvela, Emily; Walls, Melanie; Matson, Phillip

doi:10.1016/j.repbio.2013.04.005

Cited by 28 publications

(12 citation statements)

References 11 publications

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“…As discussed above, Gen II AMH assays should be used making comparing values obtained with current literature more relevant. However, even with the same Gen II assay, a wide range of average values were still reported by Zuvela et al [32]. One of the principle concerns is the effects of storage conditions varying from laboratory to laboratory resulted in the variation.…”

Section: Discussionmentioning

confidence: 95%

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Tobler

Shoham

Christianson

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to assess how anti-mullerian hormone (AMH) is used worldwide to test ovarian reserve and guide in vitro fertilization (IVF) cycle management. Methods An internet-based survey was sent electronically to registered IVF providers within the IVF-Worldwide.com network. This survey consisted of nine questions which assessed the clinics' use of AMH. The questionnaire was completed online through the IVF-Worldwide.com website, and quality assurance tools were used to verify that only one survey was completed per clinical IVF center. Results are reported as the proportion of IVF cycles represented by a particular answer choice. Results Survey responses were completed from 796 globally distributed IVF clinics, representing 593,200 IVF cycles worldwide. Sixty percent of the respondent-IVF cycles reported to use AMH as a first line test, and 54 % reported it as the best test for evaluating ovarian reserve. Eighty-nine percent reported that AMH results were extremely relevant or relevant to clinical practice. However in contrast, for predicting live birth rate, 81 % reported age as the best predictor. Conclusions AMH is currently considered a first line test for evaluating ovarian reserve and is considered relevant to clinical practice by the majority of IVF providers.

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Section: Discussionmentioning

confidence: 95%

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Tobler

Shoham

Christianson

et al. 2015

J Assist Reprod Genet

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“…In fresh serum, AMH concentrations appear to increase progressively at room temperature with the ACTIVE AMH gen II ELISA kit (Beckman‐Coulter) . All AMH estimates in our study were analyzed in frozen samples at the same laboratory and the median time before analysis was 6 days, which minimizes the risk of false values . Regarding limitations, although we found great variation in AFCs, the increase in AFC at the 6‐month post‐surgery visit in the 19 women investigated is also an interesting finding.…”

Section: Discussionmentioning

confidence: 76%

Anti‐Müllerian hormone reduction after ovarian cyst surgery is dependent on the histological cyst type and preoperative anti‐Müllerian hormone levels

Lind

Hammarström

Lampic

et al. 2014

Acta Obstet Gynecol Scand

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Objective To investigate changes in serum anti‐Müllerian hormone (AMH) concentrations following ovarian cyst surgery, and predictors of these changes. Design Prospective cohort study with follow up at 3 and 6 months. Setting University hospital. Population Women of reproductive age scheduled for ovarian cyst surgery. Methods Women were recruited between March 2011 and March 2012 (n = 75). Serum AMH concentrations were measured preoperatively and at 3 and 6 months postoperatively. Main outcome measures Changes in AMH after surgery and predictors for these changes. Results After surgery, median AMH levels decreased significantly from 2.7 μg/L (0.2–16.9) to 1.6 μg/L (0.2–9.9) at 3 months and were still low, 1.6 μg/L (0.2–8.3) at 6 months (both p < 0.001). In patients with unilateral cysts, a significant and more rapid AMH decrease was seen after enucleation of endometriomas (n = 19) vs. dermoid cysts (n = 22) (p = 0.010). The reduction was long‐lasting at 6 months. In a multivariate regression analysis, a higher baseline AMH concentration was predictive of AMH reduction at 3 [odds ratio (OR) 1.9, 95% CI 1.1–3.1] and 6 months postoperatively (OR 2.5, 95% CI 1.2–5.2). Women with normal or elevated baseline AMH presented with a significant reduction of −23% and −43% at 3 and 6 months, respectively, whereas women with low or very low AMH had minimal or no changes over time. Patient's age, cyst size, duration of surgery or intraoperative bleeding were not predictive of a postoperative AMH decrease. Conclusions Reduction of AMH was of greater magnitude and longer duration after enucleation of endometriomas and in women with normal and high preoperative AMH levels.

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“…It has also been questioned whether the laboratory methodology used to detect AMH in in vitro fertilization practice is robust. In a recent study, Zuvela et al . sought to determine whether there was variability among ten different laboratories in the measurement of AMH using the same assay.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Müllerian hormone exhibits a great variation in infertile women with different ovarian reserve patterns

Görkem

Küçükler

Toğrul

et al. 2017

Aust NZ J Obst Gynaeco

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Within-laboratory and between-laboratory variability in the measurement of anti-müllerian hormone determined within an external quality assurance scheme

Cited by 28 publications

References 11 publications

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Anti‐Müllerian hormone reduction after ovarian cyst surgery is dependent on the histological cyst type and preoperative anti‐Müllerian hormone levels

Anti‐Müllerian hormone exhibits a great variation in infertile women with different ovarian reserve patterns

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