Within-farm prevalence and environmental distribution of livestock-associated methicillin-resistant Staphylococcus aureus in farmed mink (Neovison vison)

Fertner, Mette Ely; Pedersen, Karl; Jensen, Vibeke Frøkjær; Larsen, Gitte; Lindegaard, Mikkel; Hansen, Julie Elvekjær; Chriél, Mariann

doi:10.1016/j.vetmic.2019.02.032

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…In this regard, in a recent study, LA-MRSA has been recovered from the paws of control mink groups neighboring to other minks infected with LA-MRSA spiked feed within 24 hrs following exposure to contaminated feed due to environmental dispersion. 23 In addition, the presented data from our experiment support the evidence of MRSA colonization in internal organs following oral administration.…”

Section: Discussionsupporting

confidence: 81%

Pathways of Methicillin-Resistant Staphylococcus aureus in Animal Model: New Insights Regarding Public Health

Hamza

Abd‐Elsalam

Nader

et al. 2020

IDR

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Background: Staphylococcus aureus is considered one of the major threats regarding food safety worldwide. Methicillin-resistant S. aureus (MRSA) strains in livestock, companion animals, and wild animals continue to be a potential risk to people working with them. Aim: The current research aims to investigate the potential pathways of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) strains in the body after oral infection using the experimental mouse model. Methods: Seven groups of SPF male mice were purchased and housed. On day 1, six groups of mice were infected orally by the sterile gastric probe using 100 μL/mice of LA-MRSA bacterial suspension (1 × 10 8 colony-forming units (CFU)/mL). The remaining group was kept as negative controls. Over 15 days, these animals have been monitored. Fresh fecal samples were screened for LA-MRSA at day 0, day 7 and day 14 following oral administration of MRSA strains. All animals were sacrificed at day 15, and internal organs (liver, lung, kidney, and intestine) were harvested aseptically and divided into two sections. The first part was histopathologically investigated, while the other half has been tested for LA-MRSA re-isolation. Result: The oral challenge of mice by MRSA strains showed that MRSA was re-isolated from feces and intestines of all inoculated mice groups and from internal organs (liver, lung, kidney and intestine) of most mice. Results were confirmed by the detection of the bacteria in gram-stained tissue sections and changes in H&E-stained histopathological tissue sections from these organs. Conclusion: Data from the present study indicate the possible colonization of livestockassociated methicillin-resistant Staphylococcus aureus (LA-MRSA) in internal organs following oral infection and thus posing a risk for food-borne infection of MRSA. Infected animals could pass LA-MRSA through feces again, resulting in increased dispersion and environmental contamination.

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Section: Discussionsupporting

confidence: 81%

Pathways of Methicillin-Resistant Staphylococcus aureus in Animal Model: New Insights Regarding Public Health

Hamza

Abd‐Elsalam

Nader

et al. 2020

IDR

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“…Previously, MRSA was a pathogen mostly associated with hospitals, but also people without contact to hospital environments are widely diagnosed with MRSA. MRSA has been recorded from Danish pigs [22], from retail meat [23], farmed mink [24], and horses [25]. Studies on MRSA in wild boars are currently scarce, but MRSA has been identified in wild boars from Germany and Spain [26,27].…”

mentioning

confidence: 99%

Surveillance of important bacterial and parasitic infections in Danish wild boars (Sus scrofa)

et al. 2020

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Background: Similar to the situation in other European countries, Danish wild boars may harbour a wide range of pathogens infectious to humans and domestic pigs. Although wild boars must be kept behind fences in Denmark, hunting and consumption of the meat may cause zoonotic transmission. Moreover, most infections of wild boars are transmissible to domestic pigs, which may have important economic consequences. The aim of this study was to investigate whether Danish wild boars were infected with bacteria and parasites transmissible to humans or domestic pigs: Brucella suis, methicillin-resistant Staphylococcus aureus (MRSA), Salmonella spp., Trichinella spp., lungworms and gastrointestinal parasites, especially Ascaris suum. This is the first study to investigate the prevalence of these important pathogens in Danish wild boars. Results: Wild boars from eight enclosures were analysed over a 5-year period. All tested wild boars were negative for B. suis (n = 240), MRSA (n = 244), Salmonella spp. (n = 115) and Trichinella spp. (n = 232), while eight parasite genera were identified in the faeces (n = 254): Ascaris suum, Capillaria sp., Cystoisospora suis, Eimeria spp., Metastrongylus sp. (lungworm), Strongyloides ransomi, Trichuris suis and strongylid eggs, i.e. strongyles not identified to the genera. Eimeria spp. and Metastrongylus sp. had the highest prevalence (92.3 and 79.5%, respectively) and were identified in wild boars from all eight enclosures, while the remaining parasite genera were present more sporadically. Conclusions: Wild boars from Denmark constitute a low risk of transmitting B. suis, MRSA, Salmonella spp. and Trichinella spp. to humans or domestic pigs, while economically important parasites transmissible to domestic pigs are highly prevalent in the wild boar population.

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“…On farms with LA-MRSA positive animals, the animal prevalence of LA-MRSA ranged from 20% to 29%. LA-MRSA was also isolated from the environment, including cages, but not in air samples [2].…”

Section: Archives Of Clinical and Medical Case Reports 229mentioning

confidence: 98%

Infection with MRSA CC398 Related to Occupational Exposure to Mink: A Case Report

Laustsen¹,

Omland²

2019

Arch Clin Med Case Rep

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A 59-year old man was hospitalised with dyspnoea, cough and fever, which led to respiratory treatment, later complicated with large central pulmonary embolisms. The only positive finding in samples was MRSA CC398. The patient worked several times as a full-time employee at a mink farm, which was the only exposure to MRSA CC398 in the patient's occupational history. The Danish Labour Market Insurance recognised the injury as an occupational disease; hence, exposure to LA-MRSA for working on mink farms is a new occupational risk factor in Denmark.

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Within-farm prevalence and environmental distribution of livestock-associated methicillin-resistant Staphylococcus aureus in farmed mink (Neovison vison)

Cited by 12 publications

References 24 publications

<p>Pathways of Methicillin-Resistant <em>Staphylococcus aureus</em> in Animal Model: New Insights Regarding Public Health</p>

<p>Pathways of Methicillin-Resistant <em>Staphylococcus aureus</em> in Animal Model: New Insights Regarding Public Health</p>

Surveillance of important bacterial and parasitic infections in Danish wild boars (Sus scrofa)

Infection with MRSA CC398 Related to Occupational Exposure to Mink: A Case Report

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