Within-day variability on short and long walking tests in persons with multiple sclerosis

Feys, Peter; Bibby, Bo Martin; Romberg, Anders; Santoyo, Carme; Gebara, Benoit; Noordhout, B. Maertens de; Knuts, Kathy; Béthoux, François; Skjerbæk, Anders Guldhammer; Jensen, Ellen; Baert, Ilse; Vaney, Claude; Groot, Vincent de; Dalgas, Ulrik

doi:10.1016/j.jns.2014.01.001

Cited by 42 publications

(25 citation statements)

References 32 publications

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“…This percentage corresponds to those reported in previous studies [35,36]. Moreover, regarding other studies, there is considerable variability during the same day especially for the T25FW (31%) [41].…”

Section: Discussionsupporting

confidence: 90%

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

Lecat¹,

Decavel²,

Magnin³

et al. 2017

Eur Neurol

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Background: Gait impairment is one of the most disabling symptoms in people with multiple sclerosis (PwMS). Fampridine, has demonstrated a positive effect on gait speed in PwMS after 14 days of treatment but the long-term effects have not yet been demonstrated. This study reviews the long-term effects of fampridine on gait in PwMS. Summary: This systematic review was conducted according to the PRIS-MA statement. Studies were considered long term if treatment exceeded 28 days. From the 498 studies identified, 18 (2,200 patients) fulfilled all eligibility criteria. Only 3 studies followed-up patients for >1 year and one of these showed a non-significant improvement in the gait speed. Key Messages: Fampridine seems to be beneficial at improving gait speed in PwMS in the long term. Further long-term studies are needed on related gait and functional parameters.

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Section: Discussionsupporting

confidence: 90%

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

Lecat¹,

Decavel²,

Magnin³

et al. 2017

Eur Neurol

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“…In our sample we didn’t find significant effects on gait speed measured with 10MWT probably because short-distance more than long-distance walking test are due to variability. In fact, a recent study reported a within-day variability of >20% for the 10MWT when baseline gait velocity was <1.2 m/s [39]. Another reason would be that we didn’t use the 25 foot walking test, which seems to be more reliable than 10MWT in detecting changes in PwMS [40].…”

Section: Discussionmentioning

confidence: 99%

A task-oriented circuit training in multiple sclerosis: a feasibility study

et al. 2014

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BackgroundThe aim of this study was to evaluate the safety, feasibility and preliminary effects of a high-intensity rehabilitative task-oriented circuit training (TOCT) in a sample of multiple sclerosis (MS) subjects on walking competency, mobility, fatigue and health-related quality of life (HRQoL).Methods24 MS subjects (EDSS 4.89 ± 0.54, 17 female and 7 male, 52.58 ± 11.21 years, MS duration 15.21 ± 8.68 years) have been enrolled and randomly assigned to 2 treatment groups: (i) experimental group received 10 TOCT sessions over 2 weeks (2 hours/each session) followed by a 3 months home exercise program, whereas control group did not receive any specific rehabilitation intervention. A feasibility patient-reported questionnaire was administered after TOCT. Functional outcome measures were: walking endurance (Six Minute Walk Test), gait speed (10 Meter Walk Test), mobility (Timed Up and Go test) and balance (Dynamic Gait Index). Furthermore, self-reported questionnaire of motor fatigue (Fatigue Severity Scale), walking ability (Multiple Sclerosis Walking Scale – 12) and health-related quality of life (Multiple Sclerosis Impact Scale – 29) were included. Subjects’ assessments were delivered at baseline (T0), after TOCT (T1) and 3 months of home-based exercise program (T2).ResultsAfter TOCT subjects reported a positive global rating on the received treatment. At 3 months, we found a 58.33% of adherence to the home-exercise program. After TOCT, walking ability and health-related quality of life were improved (p < 0.05) with minor retention after 3 months. The control group showed no significant changes in any variables.ConclusionsThis two weeks high-intensity task-oriented circuit class training followed by a three months home-based exercise program seems feasible and safe in MS people with moderate mobility impairments; moreover it might improve walking abilities.Trial registrationNCT01464749

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“…The distance travelled during the two minutes was recorded. In a recent study within-day reliability for the 10 meter and 2 minute walk tests for community walkers with MS was reported between 1.7–2.7 s and 16–22 m respectively [21].…”

Section: Methodsmentioning

confidence: 98%

Habitual Functional Electrical Stimulation Therapy Improves Gait Kinematics and Walking Performance, but Not Patient-Reported Functional Outcomes, of People with Multiple Sclerosis who Present with Foot-Drop

et al. 2014

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BackgroundPeople with Multiple Sclerosis (pwMS) often experience a disturbed gait function such as foot-drop. The objective of this pilot study was to investigate the medium term effects of using Functional Electrical Stimulation (FES) to treat foot-drop over a period 12 weeks on gait and patient reported outcomes of pwMS.Methods and FindingsNine pwMS aged 35 to 64 (2 males, 7 females) were assessed on four occasions; four weeks before baseline, at baseline and after six weeks and twelve weeks of FES use. Joint kinematics and performance on the 10 meter and 2 minute walk tests (10WT, 2 minWT) were assessed with and without FES. Participants also completed the MS walking Scale (MSWS), MS impact scale (MSIS29), Fatigue Severity Score (FSS) and wore an activity monitor for seven days after each assessment. Compared to unassisted walking, FES resulted in statistically significant improvements in peak dorsiflexion in swing (p = 0.006), 10MWT (p = 0.006) and 2 minWT (p = 0.002). Effect sizes for the training effect, defined as the change from unassisted walking at baseline to that at 12 weeks, indicated improved ankle angle at initial contact (2.6°, 95% CI −1° to 4°, d = 0.78), and a decrease in perceived exertion over the 2 min walking tests (−1.2 points, 95% CI −5.7 to 3.4, d = −0.86). Five participants exceeded the Minimally Detectable Change (MDC) for a training effect on the 10mWT, but only two did so for the 2 minWT. No effects of the use of FES for 12 weeks were found for MSWS, MSIS29, FSS or step count.ConclusionAlthough FES to treat foot-drop appears to offer the potential for a medium term training effect on ankle kinematics and walking speed, this was not reflected in the patient reported outcomes. This observed lack of relationship between objective walking performance and patient reported outcomes warrants further investigation.Trial RegistrationClinicalTrials.gov NCT01977287

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Within-day variability on short and long walking tests in persons with multiple sclerosis

Cited by 42 publications

References 32 publications

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

Multiple Sclerosis and Clinical Gait Analysis before and after Fampridine: A Systematic Review

A task-oriented circuit training in multiple sclerosis: a feasibility study

Habitual Functional Electrical Stimulation Therapy Improves Gait Kinematics and Walking Performance, but Not Patient-Reported Functional Outcomes, of People with Multiple Sclerosis who Present with Foot-Drop

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