Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression

Fournier, Jay C.; Chase, Henry W.; Almeida, Jorge; Phillips, Mary L.

doi:10.1016/j.bpsc.2016.03.005

Cited by 14 publications

(11 citation statements)

References 51 publications

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“…Existing (non-connectomic) studies have reported different baseline fMRI activations to cognitive [177] and emotional-tasks [178, 179] in those HR individuals who later develop a first depressive episode. Repeat functional imaging assays also suggest different trajectories of functional activation in the striatum and insula of unipolar versus bipolar depression [180]: morphological studies using sMRI likewise suggest predictors of first episode mood disorders in HR populations, [181, 182] as well as the likelihood of further mania in those with BD [183]. Moreover, different trajectories of volumetric development have also been observed in HR individuals who developed major depressive disorder relative to those who remained well [181].…”

Section: Challenges and Opportunities In Bd Connectomicsmentioning

confidence: 99%

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

et al. 2018

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The notion that specific cognitive and emotional processes arise from functionally distinct brain regions has lately shifted toward a connectivity-based approach that emphasizes the role of network-mediated integration across regions. The clinical neurosciences have likewise shifted from a predominantly lesion-based approach to a connectomic paradigm—framing disorders as diverse as stroke, schizophrenia (SCZ), and dementia as “dysconnection syndromes”. Here we position bipolar disorder (BD) within this paradigm. We first summarise the disruptions in structural, functional and effective connectivity that have been documented in BD. Not surprisingly, these disturbances show a preferential impact on circuits that support emotional processes, cognitive control and executive functions. Those at high risk (HR) for BD also show patterns of connectivity that differ from both matched control populations and those with BD, and which may thus speak to neurobiological markers of both risk and resilience. We highlight research fields that aim to link brain network disturbances to the phenotype of BD, including the study of large-scale brain dynamics, the principles of network stability and control, and the study of interoception (the perception of physiological states). Together, these findings suggest that the affective dysregulation of BD arises from dynamic instabilities in interoceptive circuits which subsequently impact on fear circuitry and cognitive control systems. We describe the resulting disturbance as a “psychosis of interoception”.

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Section: Challenges and Opportunities In Bd Connectomicsmentioning

confidence: 99%

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

et al. 2018

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“…Indeed, recent work suggests that alterations in the time course of brain function across a task, particularly to repeated presentations of emotional faces, may contribute to BD and other psychopathology. In particular, adults with BD, compared to healthy adults, exhibit more rapid attenuation of striatal‐insular connectivity in response to repeated presentation of emotional faces . Similarly, in other disorders, for example, autism, schizophrenia, social anxiety disorder, and post‐traumatic stress disorder, alterations in activation of limbic and prefrontal regions over the course of repeated presentation of emotional faces has been implicated.…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that time course of activation would differ based on age group and diagnostic status in the amygdala ROI, as well as prefrontal and striatal regions. Since change in brain activation over the course of the task has not previously been studied in youths vs adults with BD compared to healthy youths vs adults, we based these predictions on previous studies investigating average activation in this population. Due to the paucity of research using this analytic method we made no hypotheses regarding differences in directionality for prefrontal and striatal regions, however, we expected youths with BD to display decreased attenuation of activation over time in the amygdala ROIs compared to healthy youths based on findings in children with autism where emotional processing deficits have also been documented .…”

Section: Introductionmentioning

confidence: 99%

Neural mechanisms of face emotion processing in youths and adults with bipolar disorder

et al. 2019

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Objectives:Little is known about potential differences in the pathophysiology of bipolar disorder (BD) across development. The present study aimed to characterize age-related neural mechanisms of BD.Methods: Youths and adults with and without BD (N = 108, age range = 9.8-55.9 years) completed an emotional face labeling task during fMRI acquisition. We leveraged three different fMRI analytic tools to identify age-related neural mechanisms of BD, investigating (a) change in neural responses over the course of the task, (b) neural activation averaged across the entire task, and (c) amygdala functional connectivity. Results:We found converging Age Group × Diagnosis patterns across all three analytic methods. Compared to healthy youths vs adults, youths vs adults with BD show an altered pattern in response to repeated presentation of emotional faces in medial prefrontal, amygdala, and temporoparietal regions, as well as amygdala-temporoparietal connectivity. Specifically, medial prefrontal and lingual activation decreases over the course of repeated emotional face presentations in healthy youths vs adults but increases in youths with BD compared to adults with BD. Moreover, youths vs adults with BD show less medial prefrontal activation and amygdala-temporoparietal junction connectivity averaged over the task, but this difference is not found for healthy youths vs adults. Conclusion:Although longitudinal confirmation and replication will be necessary, these findings suggest that neural development may be aberrant in BD and that some neural mechanisms mediating BD may differ in adults vs children with the illness. K E Y W O R D S bipolar disorder, development, face emotion, fMRI, pediatric S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Kryza-Lacombe M, Brotman MA, Reynolds RC, et al. Neural mechanisms of face emotion processing in youths and adults with bipolar disorder. Bipolar Disord. 2019;21:309-320. https://doi.

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“…Some researchers have hypothesized that BD may develop a progressive path over time in particular in a subgroup of BD patients who showed initial subtle cognitive impairments and were more likely to develop chronicity [ 22 , 23 ]. In addition, several neuroimaging studies showed specific brain abnormalities in BD in order to validate the neuroprogressive hypothesis underlying this condition, with the most relevant findings referring to the presence of both regional structural and functional alterations, predominantly in the striatal–insular–thalamic and temporo–parietal associated regions [ 24 ], at least in a specific subgroup of subjects.…”

Section: Introductionmentioning

confidence: 99%

Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature

et al. 2021

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Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.

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Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression

Cited by 14 publications

References 51 publications

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

Neural mechanisms of face emotion processing in youths and adults with bipolar disorder

Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature

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