WITHDRAWN: The role of tumor size, ultrasonographic findings, and serum tumor markers to predict the likelihood of malignant testicular histology

Gang, Song Woon; Fan, Yu; Xiong, Gengyan; Ji, Guangjie; Huang, Cong; Kang, Yongming; Chen, Jinchao; Ren, Da; He, Qun; Wang, He; Gao, Shan; Liu, Shuqing; He, Zhisong; Zhou, Liqun

doi:10.18632/oncotarget.23802

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“…In patients with hilar soft tissue involvement, the mean tumor size was 6.25 cm (2.5-10 cm), and tumor diameter was longer than other patients (6.25-4.96 cm, respectively). As it is known, when the tumor diameter increases, possibility of malignancy increases in scrotal masses [10,11]. In our study, the probability of malignancy in testicular tumors and hilar soft tissue involvement increased when the tumor diameter increased.…”

Section: Discussionsupporting

confidence: 54%

What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Ediz¹,

İhvan²

2019

Urol Int

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Background: The significance of hilar soft tissue invasion of rete testis in malign germ cell tumors is still controversial on current guidelines. Objectives: We aimed to investigate the importance of hilar soft tissue involvement in germ cell tumors and evaluated the possibility of a risk factor such as rete testis. Method: Totally, 59 radical orchiectomy specimens operated between 2007 and 2015 at our clinics. All records were retrospectively researched. Patients’ age, level of tumor markers, tumor size, histological subtype, clinical stage, presence or absence of carcinoma in situ, vascular/lymphatic and/or hilar soft tissue invasion, tumoral necrosis, number, site and diameter of metastasis, type of further treatment (radiotherapy or chemotheraphy) and follow-up period were recorded and evaluated for all patients. Results: Twenty-six of totally 59 malign germ cell tumors were seminomatous and 33 were nonseminomatous (NS). Mean patients age was 38.54 years (range 17–89 years). Mean follow-up duration was 39.84 months (range 3–96). Serum tumor marker levels were found associated with rete testis invasion (p = 0.035). Hilar soft tissue invasion was significantly associated with vascular invasion (p = 0.001). As it was expected, vascular invasion was significantly associated with metastasis (p = 0.024). Conclusions: We concluded that there is a strong association between hilar soft tissue invasion and vascular invasion. Especially in NS germ cell tumors, hilar soft tissue involvement a risk factor for prognosis and to determine the need for additional treatment. According to our study, hilar soft tissue status should be reported on routine pathology report.

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Section: Discussionsupporting

confidence: 54%