WITHDRAWN: Significant amounts of melatonin in red wine: Its consumption increases blood melatonin levels in humans

Guerrero, Juan M.; Martinez-Cruz, Francisco; Elorza, Félix López

doi:10.1016/j.foodchem.2008.02.007

Cited by 9 publications

(8 citation statements)

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“…Once again, treatments with plant activators improve melatonin biosynthesis in grapes, as reported for the Merlot cultivar [60]. As expected, melatonin also has been detected in wine, with concentrations ranging from 0.05 to 0.5 ng/g, and, interestingly, in humans, whose serum melatonin level increased significantly after red wine intake (1h after a single 100 mL supplementation) [67,68].…”

Section: Grape Chemistrysupporting

confidence: 70%

Bioactivity of Grape Chemicals for Human Health

Iriti

Faoro

2009

Natural Product Communications

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Grapevine (Vitis vinifera) products, grape and grape juice, represent a valuable source of bioactive phytochemicals, synthesized by three secondary metabolic pathways (phenylpropanoid, isoprenoid and alkaloid biosynthetic routes) and stored in different plant tissues. In the last decades, compelling evidence suggested that regular consumption of these products may contribute to reducing the incidence of chronic illnesses, such as cancer, cardiovascular diseases, ischemic stroke, neurodegenerative disorders and aging, in a context of the Mediterranean dietary tradition. The health benefits arising from grape product intake can be ascribed to the potpourri of biologically active chemicals occurring in grapes. Among them, the recently discovered presence of melatonin adds a new element to the already complex grape chemistry. Melatonin, and its possible synergistic action with the great variety of polyphenols, contributes to further explaining the observed health benefits associated with regular grape product consumption.

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Section: Grape Chemistrysupporting

confidence: 70%

Bioactivity of Grape Chemicals for Human Health

Iriti

Faoro

2009

Natural Product Communications

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“…This dose of melatonin would require drinking more than 1000 L of wine per day! We acknowledge the fact that the amount of melatonin given directly to the isolated heart is higher than the amount that the heart would receive after ingestion of red wine, but half an hour after drinking 100 mL of red wine, the amount of melatonin in the blood is increased by approximately 20% [6].…”

Section: Discussionmentioning

confidence: 99%

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection

Lamont¹,

Somers²,

Lacerda³

et al. 2011

Journal of Pineal Research

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Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain unclear. Recent studies demonstrate the presence of melatonin in wine. We propose that melatonin, at a concentration found in red wine, confers cardioprotection against ischemia-reperfusion injury. Furthermore, we investigated whether both melatonin and resveratrol protect via the activation of the newly discovered survivor activating factor enhancement (SAFE) prosurvival signaling pathway that involves the activation of tumor necrosis factor alpha (TNFα) and the signal transducer and activator of transcription 3 (STAT3). Isolated perfused male mouse (wild type, TNFα receptor 2 knockout mice, and cardiomyocyte-specific STAT3-deficient mice) or rat hearts (Wistars) were subjected to ischemia-reperfusion. Resveratrol (2.3 mg/L) or melatonin (75 ng/L) was perfused for 15 min with a 10-min washout period prior to an ischemia-reperfusion insult. Infarct size was measured at the end of the protocol, and Western blot analysis was performed to evaluate STAT3 activation prior to the ischemic insult. Both resveratrol and melatonin, at concentrations found in red wine, significantly reduced infarct size compared with control hearts in wild-type mouse hearts (25 ± 3% and 25 ± 3% respectively versus control 69 ± 3%, P < 0.001) but failed to protect in TNF receptor 2 knockout or STAT3-deficient mice. Furthermore, perfusion with either melatonin or resveratrol increased STAT3 phosphorylation prior to ischemia by 79% and 50%, respectively (P < 0.001 versus control). Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway.

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“…For a long time it was thought that melatonin is a neurohormone exclusively synthesized in vertebrates, but in recent years it was found that this substance is presented in plants, bacteria, algae, fungi and invertebrates (Iriti & Faoro 2006). Few years ago, discovered melatonin in different grape cultivars, which gave a boost of series of studies concerning the presence and biosynthesis of this compound in grape and wine (Guerrero et al, 2008;Mercolini et al, 2008). Melatonin content in grape is reported to range from 5 to 96 pg/g, while in wine the content was found to vary from 50-80 pg/ml (Spanish wines) to 400-500 pg/ml (Italian wines) with higher content in red wines (Iriti et al, 2010).…”

Section: Melatoninmentioning

confidence: 99%

“…Melatonin content in grape is reported to range from 5 to 96 pg/g, while in wine the content was found to vary from 50-80 pg/ml (Spanish wines) to 400-500 pg/ml (Italian wines) with higher content in red wines (Iriti et al, 2010). It was reported that the human serum concentration of melatonin significantly increases 1 hour after intake of 100 ml red wine (Guerrero et al, 2008), resulting in increased plasma antioxidant capacity. These results show that the effect of this neurohormone in humans could be modulated by moderate administration of wine.…”

Section: Melatoninmentioning

confidence: 99%