WITHDRAWN: Relationships Between Serum α-Klotho Concentration and Inflammation-Related Cytokines in Hemodialysis Patients

Abstract

We investigated the relationship between α-Klotho and cytokines related to inflammation in HD patients. We analyzed levels of α-Klotho with ELISA and inflammatory cytokines with CBA in the serum of HD patients. There was a significant negative correlation between the concentration of serum α-Klotho and patients’ age and the serum concentration of PTH. No correlation has been found between α-Klotho and Ca or Pi. HD time, creatynine or eGFR. However, there were significant positive correlations between the concentration of α-Klotho and the serum concentration of IL-12p70, IL-10, and IL-1β. Furthermore, the concentration of IL-10 and IL-1β was significantly lower in HD patients with low α-Klotho concentrations compared with HD patients with high α-Klotho. However, in a multivariable linear regression analysis, only patients’ age was associated independently with α-Klotho level. While these results draw our attention to potential relationships between α-Klotho proteins and inflammatory markers in HD patients, our cross-sectional study could not fully explain the pathogenic link between α-Klotho and inflammation in these patients. Therefore, further studies are necessary to clarify these relationships. However, this observation aligns with previous studies that confirm a significant relationship between Klotho concentration and human aging.