“…Recently, Hydrazine group bearing 1,2,4-triazines are used to synthesize an important heterocyclic nitrogen system with various functional group [1], in addition both the pyrazoles [2] and pyrimidines [3] exhibit medicinal, pharmacological and biological activities. The introduction of fluorine C-F and CF 3 group to heterocyclic systems often improves and enhances their properties.…”