10OBJECTIVE: Meningitis after microsurgery for vestibular schwannoma (VS) is a 11 severe complication and result in high morbidity. But few studies have focused on 12 meningitis after VS surgery alone. The purpose of this study was to identify the risk 13 factors for meningitis after VS surgery. 14 METHODS: We undertook a retrospective analysis of all VS patients, who underwent 15 microsurgery of VS and at least live for 7 days after surgery, between 1st June 2015 16 and 30st November 2018 at West China Hospital of Sichuan University. Univariate and 17 multivariate analyses were performed to identify the risk factors for postoperative 18 meningitis (POM). 19 RESULTS: We collected 410 patients, 27 of whom had POM. Through univariate 20 analysis, hydrocephalus (p=0. 018), Koos grade IV(p=0.04), The operative duration 21 (> 3 hours p=0.03) and intraoperative bleeding volume (≥ 400ml p=0. 02) were 22 significantly correlated to POM. Multivariate analysis showed that Koos grade IV 23 (p=0.04; OR=3.19; 95% CI 1.032-3.190), operation duration (> 3 hours p=0.03 OR= 24 7.927; 95% CI 1.043-60.265), and intraoperative bleeding volume (≥ 400ml p=0.02; 25 OR=2.551; 95% CI 1.112-5.850) are the independent influencing factors of POM.26 CONCLUSIONS: Koos grade IV, the duration of operation, and the amount of 27 bleeding were identified as independent risk factors for POM after microsurgery of VS. 28 POM caused a prolonged hospital stay. 3 29 4 48 This study retrospectively collected 410 patients at the Department of Neurosurgery in 49 West China Hospital of Sichuan University, who underwent microsurgery of VS and 50 survived at least 7 days after surgery, between 1st June 2015 and 30st November 2018.
51We did this study from January to February 2019. The diagnosis was based on MRI and 52 pathology. MRI showed a mass rising from the vestibular nerve, and pathology showed 53 schwannoma. This study was approved by the West China Hospital Ethics Committee.
54Written informed consent was exempted for the present study was a retrospective 55 clinical study.
56Data collection 57 The basic information of these patients were collected, which include age, sex, BMI, 58 signs and symptoms, presence/absence of diabetes mellitus, preoperative white blood 59 cell count and hemoglobin concentration, presence/absence of hydrocephalus (assessed 60 by magnetic resonance imaging), side and size of the tumor, history of treatment of 61 microsurgery and/or stereotactic radiosurgery for VS, length of preoperative and 62 postoperative hospitalization, surgery duration, bleeding amount of the operation, 63 invasive operation, subcutaneous drainage and Lumbar drainage, Cerebrospinal fluid 64 test data about the patients who underwent cerebrospinal fluid drainage. 65 Koos grade of VS 66 Koos grade was utilized for the classification of VS, According to the magnetic 67 resonance imaging of the patients and the tumor size. VS was categorized into grade I,