WITHDRAWN: Loss of miR-494 by exosomes promotes melanoma proliferation and metastasis

Abstract

Previous studies have established that exosomes involve material transport in melanoma. However, the detail molecular mechanisms remain to be elucidated. Here, we aimed to determine the functions of exosome-derived miR-494 in melanoma progress. In this study, we firstly found significantly higher levels of miR-494 in melanoma patients' serum exosomes. miR-494 was upregulated in high-metastaic melanoma cell exosomes while downregulated in cell itself.. Functional studies revealed that decrease exosome production and overexpression of miR-494 significantly inhibited cancer cells proliferation, migration and invasion in vitro. Nude mice experiments confirmed that upregulation miR-494 suppressed tumor growth and metastasis by inhibiting exosomes release in vivo. In conclusion, Exosomal transfer of miR-494 is an alternative modality in the treatment of melanoma.