Few-shot learning has recently attracted wide interest in image classification, but almost all the current public benchmarks are focused on natural images. The fewshot paradigm is highly relevant in medical-imaging applications due to the scarcity of labeled data, as annotations are expensive and require specialized expertise. However, in medical imaging, few-shot learning research is sparse, limited to private data sets and is at its early stage. In particular, the few-shot setting is of high interest in histology (study of diseased tissues with microscopic images) due to the diversity and fine granularity of cancer related tissue classification tasks, and the variety of data-preparation techniques, which results in covariate shifts in the inputs and disparities in the labels. This paper introduces a highly diversified public benchmark, gathered from various public datasets, for few-shot histology data classification. We build few-shot tasks and base-training data with various tissue types, different levels of domain shifts stemming from various cancer sites, and different class-granularity levels, thereby reflecting realistic scenarios. We evaluate the performances of state-of-the-art few-shot learning methods on our benchmark, and observe that simple fine-tuning and regularization methods achieve significantly better results than the popular meta-learning and episodictraining paradigm. Furthermore, we introduce three scenarios based on the domain shifts between the source and target histology data: (i) near-domain, (ii) middledomain and (iii) out-domain. Our experiments display the potential of few-shot learning in histology classification, with state-of-art few shot learning methods approaching the supervised-learning baselines in the near-domain setting. In our out-domain setting, for 5 way 5 shot, the best performing method reaches 60% accuracy. We believe that our work could help in building realistic evaluations and fair comparisons of few-shot learning methods and will further encourage research in the few-shot paradigm. Our code and few-shot histology tasks are publicly available 2 .