WITHDRAWN: Establishment and validation of a novel metabolism-related genesignature for predicting overall survival of patients with breast cancer

Abstract

Background: It is well known that Breast cancer is a heterogeneous disease. Although the current recurrence and mortality rate have been greatly improved, many people still suffer relapse and metastasis. Metabolic reprograming is currently considered to be a new hallmark of cancer. Therefore, in this study, we comprehensively analyzed the prognostic effect of metabolic-related gene signatures in breast cancer and its relationship with the immune microenvironment. Result: The metabolic gene signature may be an independent risk factor for BC both in the training and the testing set,the nomogram has a moderately accurate performance, and the C index was 0.757 and 0.728 respectively. The signature can reveal metabolic characteristics based on gene set enrichment analysis and at the same time monitor the status of TME. Conclusion: This gene signature can be used as a promising independent prognostic marker for BC patients, and can indicate the current status of TME, providing more clues for exploring new diagnostic and treatment strategies.