WITHDRAWN: Endometriosis related sex steroid hormones, hypothalamic pituitary gonadal axis hormones and related animal modeling: A comprehensive review of published articles and endometriosis induction methods from 2010 to 2021 with scoring based approach

Abstract

Endometriosis is an enigmatic gynecological disease initiated by the ectopic growth of endometrial tissue and causes critical symptoms such as chronic pelvic pain, cyclic menstrual pain, subfertility or infertility. Considering extensive investigations for explaining the underlying pathophysiology of endometriosis, origin and distinctive processes which lead to endometritic state are not completely understood. In this comprehensive review, studies published from 2010 to 2021 are reviewed in order to provide a bright insight through the applications of translational animal models and endometriosis induction methods for evaluation of endometriosis pathogenesis and treatment. We provided method based inclusion criteria and reviewed all hormone-based studies with concentration on animal models. Additionally, studies with novel induction methods and approaches are categorized separately and analyzed by a novel scoring table for suitability of further investigations. Eventually, our scoring system suggested that the best-evaluated animal model for hormone related endometriosis studies is an “unopposed estrogenicity baboon model of endometriosis”.