WITHDRAWN: Computational modeling of multiple myeloma growth and tumor aggregate formation

Urdeitx, Pau; Clara-Trujillo, Sandra; Ribelles, J.L. Gómez; Doweidar, Mohamed H.

doi:10.1016/j.cmpbup.2022.100073

Cited by 2 publications

(2 citation statements)

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“…The suspension of microspheres and cells was maintained under gentle orbital agitation. The characteristics of the environment of the cells cultured in this system were simulated by finite element analysis in a recent work [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture

et al. 2022

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Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone marrow environment. Proliferation and viability of nPCs depend on their interaction with the stromal cells and the extracellular matrix components, which also influences the appearance of drug resistance. Recapitulating these interactions in an in vitro culture requires 3D environments that incorporate the biomolecules of interest. In this work, we studied the proliferation and viability of three multiple myeloma cell lines in a microgel consisting of biostable microspheres with fibronectin (FN) on their surfaces. We also showed that the interaction of the RPMI8226 cell line with FN induced cell arrest in the G0/G1 cell cycle phase. RPMI8226 cells developed a significant resistance to dexamethasone, which was reduced when they were treated with dexamethasone and bortezomib in combination.

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Section: Resultsmentioning

confidence: 99%

Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture

et al. 2022

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“…Thus, the cell Maturation Index (MI), referred to the cell-cycle progression, is a time-dependent process in which the cell evaluates and responds to the specific mechanical and chemical conditions to which it is subjected [55,58]. It can be defined as [28,59]:…”

Section: Modeling Of Cell Proliferationmentioning

confidence: 99%