WITHDRAWN: Analysis of Colorectal Cancer Trends, Clinicopathological Features, Surgical Treatment Patterns, Prognoses, and Nomogram for Survival Predicting: A Retrospective Cohort Study on Patients Managed from 2019 to 2021 at West Kazakhstan

Abstract

Background/Objective This retrospective cohort study aimed to comprehensively analyze colorectal cancer (CRC) trends, clinico-pathological features, surgical treatment patterns, and prognoses among patients managed from 2019 to 2021 at the West Kazakhstan Medical University. Methods Medical records of 420 patients diagnosed with CRC were retrospectively analyzed. Univariate and multivariate regression analyses were conducted to explore the impact of demographic, clinical, and molecular factors on CRC characteristics, progression, treatment, and cancer-related mortality. Results Univariate analyses revealed that age, tumor morphology, tumor stage, tumor infiltration depth, lymph node involvement, and metastasis significantly influenced CRC outcomes. Notably, older age (> 65 years) was associated with reduced cancer progression. Adenocarcinomas with higher grades displayed negative correlations with disease progression, and tumor stage exhibited strong associations with progression and prognosis. Multivariate analyses confirmed these findings, highlighting the complex interactions between these factors. Conclusion This study provides a comprehensive assessment of CRC trends, clinico-pathological features, treatment patterns, and prognoses. The integration of univariate and multivariate analyses enhances our understanding of the intricate interplay of demographic, clinical, and molecular factors in shaping CRC outcomes. Personalized treatment approaches considering these interactions could improve CRC care.