WITHDRAWN: An Oryza-specific hydroxycinnamoyl tyramine gene cluster contributes to enhanced disease resistance

The emerging role of biosynthetic gene clusters in plant defense and plant interactions

“…The discovery of these gene clusters has facilitated elucidation of complex metabolic pathways and revealed genetic mechanisms for chemical diversification. It has further enabled the roles of newly discovered BGC pathway products in interactions between plants and other organisms to be shown, as demonstrated by the combined use of gene silencing and plant–pathogen assays [ 23 , 28 , 60 ]. The inventory of characterized BGCs will inevitably continue to increase as sequencing technologies continue to develop and become cheaper, and more plant genome sequences become available.…”

“…However, knowledge of the expression profiles of the newly discovered pathway genes and of the fate of the compounds that these pathways produce (for example, secretion from the root) may provide clues as to their possible roles [21]. WhereAU : PleaseconfirmthattheeditstothesentenceWherepossible; biologicalfunctioncanthenbetes possible, biological function can then be tested by generating plant lines that do not produce the compound(s) of interest by mutation, gene silencing, or gene editing, and evaluating these for altered abiotic/biotic stress tolerance [23,28,60].…”

“…BGCs have not been identified for some prominent groups of plant natural products (e.g., carotenoids and glucosinolates). For phenylpropanoids, a large, structurally diverse, and widely distributed class of compounds that includes many defense-related molecules [ 22 ], a first BGC has only recently been reported [ 23 ]. However, multispecies in silico analysis has predicted the existence of phenylpropanoid clusters in plant genomes in similar numbers to those of terpenoids and alkaloids [ 14 ].…”

Functional elucidation of an <italic>Oryza</italic>-specific hydroxycinnamoyltyramine gene cluster

“…Oryza-Specific Hydroxycinnamoyl Tyramine Gene Cluster Contributes to Enhanced Disease Resistance 的研究论文 [7] ，研究揭示一个稻属特异的羟基肉桂酰酪胺生物 [6,8] 。 最近， Anne Osbourn 研究团队比较 1001 中拟南芥基因组中 Thalianol BGC 的变化情况， 发现染色体倒位 (Chromosomal inversion) 可能是生物合成基因簇招募新基因 (离 已有的基因簇较远)加入的主要分子机制 [9] 。但到目前为止，为什么会形成物种 特异的植物生物合成基因簇(多数植物特异性代谢途径基因并不形成基因簇)依 然是一个待解的科学问题，随着更多的植物生物合成基因簇的功能得到明确，人 们对这一问题的认识也会越来越深刻。 图 1. 水稻特异羟基肉桂酰酪胺基因簇参与病原菌抗病 (部分信息修改自文献 [7]) 。 Figure 1. An Oryza-specific hydroxycinnamoyl tyramine gene cluster is involved in disease resistance (partially modified from Ref.…”

“…An Oryza-specific hydroxycinnamoyl tyramine gene cluster is involved in disease resistance (partially modified from Ref. [7]).…”