WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer

Chen, Kai; Li, Yajie; Xu, Hui; Zhang, Chunfeng; Li, Zhiqiang; Wang, Wei; Wang, Baofeng

doi:10.1016/j.gene.2017.08.010

Cited by 1 publication

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References 37 publications

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“…It has been reported that, PARP‐1 was highly expressed in NSCLC, reducing the effects of CBP in NSCLC. And PARP‐1 as oncogene was found to effect NSCLC cell migration through known oncogene in terms of gene interaction network (Chen, Li, Xu, Zhang, & Wang, ). Furthermore, PARP inhibition significantly decreased cell viability, migration, invasion, chromatin loop dimensions, and histone acetylation, and it could play a key role in the compartmentalization of chromatin and in the development of the more aggressive phenotype (Barboro et al, ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma

2020

Molec Gen & Gen Med

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This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Breast carcinoma has become a nonnegligible public health problem in China with its increasing incidence and mortality in woman. As a early event regulating tumorigenesis and development, DNA methylation became one of the focuses of current carcinoma researches on potential diagnostic and therapeutic targets. Methods: In this study, we comprehensively analyzed the gene expression data and DNA methylation data of breast carcinoma and adjacent normal tissues samples in the Gene Expression Omnibus database. Influences of tumor stage, adjuvant therapy, hormone therapy, and chemotherapy on CpG methylation level were explored by linear regression analysis. Correlations between methylation and gene expression levels were determined by spearman rank correlation analysis. Log-rank test was applied for determining significance of associations between CpG sites methylation level and breast cancer patients' Kaplan-Meier survival. Results: A total of 229 CpG sites were found to be significantly associated with tumor stage or treatment, and eight of which were potential markers that affect the survival of breast carcinoma and negatively correlated with their genes' expression levels. Conclusions: We reported eight CpG sites as potential breast cancer prognosis signatures through comprehensively analyzed gene expression and DNA methylation datasets, and excluding influences of tumor stage and treatment. This should be helpful for breast cancer early diagnosis and treatment. K E Y W O R D S breast carcinoma, CpG island, DNA methylation, prognosis SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section. How to cite this article: Li J, Li X. Comprehensive analysis of prognosis-related methylated sites in breast carcinoma. Mol Genet Genomic Med. 2020;8:e1161.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma

2020

Molec Gen & Gen Med

View full text Add to dashboard Cite

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WITHDRAWN: An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer

Cited by 1 publication

References 37 publications

Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma

Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma

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