Withasteroids, a Growing Group of Naturally Occurring Steroidal Lactones

Ray, Arnab; Gupta, Mohini

doi:10.1007/978-3-7091-9281-8_1

Cited by 86 publications

(105 citation statements)

References 200 publications

(358 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The acnistins also exhibit a bicyclic side chain involving C-21 and the lactone ring but, at variance with withametelins, C-21 is directly bonded to C-24 via a C-C bond instead of an ether bond (3,4). It has been proposed that the 21,24 bond is probably formed via a SN 2 type reaction in withanolides having a good leaving group at C-21.…”

Section: Acnistinsmentioning

confidence: 99%

“…The physalins are a group of 13,14-seco-16,24-cycloergostane constituents of certain Physalis species (3,133). In recent years, some known physalins have been found in Brachistus stramoniifolius (physalins B, F, and H) (134) (138).…”

Section: Physalins and Withaphysalinsmentioning

confidence: 99%

“…The antibacterial and antifungal properties of withaferin A (1) have been known for a long time and many other withanolides are known to display these activities (3,4). However, data are scattered throughout the literature involving the action of different compounds on different microorganisms thus making it difficult to rationalize the results.…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

“…Several withanolides also exhibit insecticidal activities, mostly as feedant deterrents, and selective phytotoxicity. A number of review articles have dealt with structural aspects of this group of compounds (3)(4)(5) as well as with their biological activities (6,7). The present chapter covers developments and findings in the chemistry and bioactivity of withanolides and related compounds since 1994.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Withanolides and Related Steroids

Misico

Nicotra

Oberti

et al. 2011

Progress in the Chemistry of Organic Natural Products Vol. 94

View full text Add to dashboard Cite

Section: Acnistinsmentioning

confidence: 99%

Section: Physalins and Withaphysalinsmentioning

confidence: 99%

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Withanolides and Related Steroids

Misico

Nicotra

Oberti

et al. 2011

Progress in the Chemistry of Organic Natural Products Vol. 94

View full text Add to dashboard Cite

“…Peoples of local rural areas of Pakistan use extract of this plant for treating numerous neurological diseases (Hassan et al, 1994). Ajuga bracteosa contains diterpenoids and withanolides (Glotter 1991) which are responsible for various biological activities (Gautam et al, 2010;Riaz et al, 2007;Kuria et al, 2002;Ray et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Physio-chemical evaluation and biological activity of <i>Ajuga bracteosa</i> wall and <i>Viola odoroto</i> Linn

Shad¹,

Zeeshan²,

Fazal³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: Ajuga bracteosa and Viola odorata are frequently used by the native people of Swat-Pakistan for the curing of fever, malaria, cough, urinary and stomach disorders with slightly different practice of usage like raw powdered, extracts, decoction etc. Methods and Materials: Disc Diffusion Method was used for determination of antimicrobial activities of both plants. Nutrient Agar Media was used for the culturing and growth of all microbial strains. Vitamin C and minerals contents were determined by standard method of AOAC. Na and K were analyzed by using flame photometric technique. Micro minerals i.e. "Ni, Cr, Fe, Cu, Zn, Mn, Ca, Pb, and Mg" were determined by Atomic Absorption Spectrophotometer (AAS). Total Soluble Solid (TSS) was determined by using abbe refractometer and pH was determined by using pH meter. Results: The present study demonstrates that both plants exhibited antibacterial activities against P. aeruginos, E. coli, S. typhi, B. subtilis and S. aureus. The examined plants showed zone of inhibition for aqueous fraction (50.90, 45.90 %) against P. aeruginosa; for EtOAc fraction (41.37, 57.62%) against C. Albicans and for hexane fraction (25.86, 40.57%) against K. pneumoniae, respectively. Total of 14 different minerals (Na, K, P, Ca, Mg, Fe, Zn, Mn, Co, Cr, Ni, Cu, Pb, Cd) were determined and it was also observed that both the examined plants contained significant level of these analyzed minerals. The subject plants contained highest level of magnesium (295.75, 145.85 mg 100 -1 g) and calcium (212.49, 44.00 mg 100 -1 g) and potassium (152.6, 437.45 mg 100 -1 g) while moderate level P, Zn, Na and lower amount of Cd, Ni, Mn and Cu using Atomic Absorption, Flame Photometry and spectrophotometric techniques. V. odorata was found to contain a higher amount of vitamin C (64.05±12.37mg 100 -1 g) as compared to A. bracteosa (45.45 ± 7.29 mg 100 -1 g). Conclusion: Findings of this study can persuade researchers for future comprehensive phytochemical study of these plants using state of art techniques and instruments, which include not only isolation of secondary metabolites from these plants but biological evaluation of isolated compounds both in vivo and in vitro

show abstract