Withanolides from Withania somnifera roots

Misra, Laxminarain; Mishra, Prachi; Pandey, Archana; Sangwan, Rajender S.; Sangwan, Neelam S.; Tuli, Rakesh

doi:10.1016/j.phytochem.2007.10.024

Cited by 141 publications

(74 citation statements)

References 8 publications

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“…Also, the chlorinated withanolide Z (27) (28), arising from trans-diaxial cleavage of the 6,7-epoxide and the D 7 -withanolide 28 (24) are known. Compound 29 contains an unusual 5a,7a-epoxy bridge that would result from rearrangement of the 5a-hydroxy-6a,7a-epoxide (26 As mentioned above, the 1a,3b-dihydroxy arrangement is a well-known structural variation among the withanolides and several examples have been shown in combination with 5b,6b-or 6a,7a-epoxides. Eleven 3b-O-glycosides isolated from W. somnifera contained the 1a,3b-dihydroxy arrangement combined with a 5,6-double bond in ring B.…”

Section: B6b-epoxywithanolides and Related Compoundsmentioning

confidence: 94%

“…Withanoside IV (31) and VI (32) predominantly induced dendritic outgrowth in normal cortical neurons, while withanolide A (504) predominantly induced axon outgrowth (262). These withanolides also showed neuritic regeneration and synaptic reconstruction of damaged cortical neurons and prevented both dendritic and axonal atrophy induced by Ab (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) (261,263). Oral administration of withanoside IV significantly improved memory deficit in Ab(25-35) treated mice, and sominone, the aglycone of withanoside IV, was shown to be the major metabolite after administration.…”

Section: Synaptogenesis and Neuritic Outgrowthmentioning

confidence: 97%

“…In the case of 13 the configuration of the hydroxy group at C-16 was not determined (15 The 5a-hydroxy-6a,7a-epoxy substitution pattern is also a common arrangement found in W. somnifera withanolides. Simple variations arising from the combination of hydroxy substituents at both typical positions (C-14, C-17, C-20) and some less common ones such as C-16 or C-23 are observed in withasomniferols A (15) and B (16) (24), 14a,17a-dihydroxywithanolide R (17) (20), isowithanone (18) (25), and the 16b-acetate 19 (26). Withasomniferol B (16) is a stereoisomer of the known ixocarpanolide, although the configurations at positions 24 and 25 were not specified.…”

Section: B6b-epoxywithanolides and Related Compoundsmentioning

confidence: 99%

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Withanolides and Related Steroids

Misico

Nicotra

Oberti

et al. 2011

Progress in the Chemistry of Organic Natural Products Vol. 94

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Section: B6b-epoxywithanolides and Related Compoundsmentioning

confidence: 94%

Section: Synaptogenesis and Neuritic Outgrowthmentioning

confidence: 97%

Section: B6b-epoxywithanolides and Related Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Withanolides and Related Steroids

Misico

Nicotra

Oberti

et al. 2011

Progress in the Chemistry of Organic Natural Products Vol. 94

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“…Withanolides have C28 steroidal nucleus with C9 side chain, having a six membered lactone ring ( Figure 1). The oxidation at various sites of the skeleton is responsible for the structural deviations in different classes of withanolides [11][12][13][14]. Literatures reported that withanolides such as withaferin A, withanolide D, withanolide E, etc.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Physical, Spectroscopic, and Thermal Characterization of Withania somnifera (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect®)

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

IJBMR

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Abstract:Withania somnifera (Ashwagandha) root extract possesses a broad range of pharmacological activities. The aim of current study was to explore the impact of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the physical, spectroscopic, and thermal properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect ® -Biofield Energy Treated sample, which received The Trivedi Effect ® Treatment remotely from eighteen renowned Biofield Energy Healers. The PXRD analysis exhibited that both the control and The Trivedi Effect ® -Biofield Energy Treated samples were amorphous in nature. The particle size values at d 10 and d 50 of the treated sample were decreased by 4.66% and 6.02% and at d 90 slightly increased by 0.99% compared with the control sample. The average surface area of the treated (0.130 m 2 /g) sample was increased by 4.84% compared with the control (0.124 m 2 /g) sample. The FT-IR results suggested that the force constant of O-H (stretching), and C-O (stretching) functional groups of the treated sample were reduced compared with the control sample. The UV-vis analysis revealed that the wavelength for the maximum absorbance of the control and treated samples were at 205.4 nm and 205.6 nm, respectively. The TGA thermograms exhibited three steps of the degradation process, and the total weight loss of the treated (86.45%) sample was increased by 1.44% compared with the control (85.22%) sample. The DSC analysis revealed that melting point of the treated (201.67°C) sample was reduced by 0.87% compared with the control (203.43°C) sample. The latent heat of fusion of the treated (6.77 J/g) sample was significantly decreased by 21.82% compared to the control (8.67 J/g) sample. Hence, the treated sample would be more advantageous for the better therapeutic responses compared to the control sample. These findings suggest that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might have the astounding capacity to enhance the solubility, dissolution, absorption, and bioavailability of ashwagandha root extract in various forms of pharmaceutical/nutraceutical formulations by modifying its particle size and surface area. Thus, The Trivedi Effect ® -Energy of Consciousness Healing Treated ashwagandha root extract might provide better therapeutic response against inflammatory diseases, immunological disorders, stress, arthritis, cancer, diabetes, sexual disorders, aging and other chronic infections.

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“…Withanolides have steroidal nucleus with side chain, having a six membered lactone ring. The oxidation at various sites of skeleton is responsible for the structural deviations in different classes of withanolides [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Consciousness Energy Healing Treatment on Withania somnifera Root Extract and Its Effects on the Physical, Spectroscopic, Thermal and Behavioral Properties

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

AJCHE

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Abstract:Withania somnifera (Ashwagandha) is useful as an herbal medicine and nutraceuticals for the prevention and treatment of anxiety, insomnia, tuberculosis, tumors, menstrual problems, etc. The objective of the current study was to evaluate the influence of The Trivedi Effect ® -Consciousness Energy Healing Treatment on the physical, spectroscopic, thermal and behavioral properties of ashwagandha root extract using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Ashwagandha root extract was divided into two parts -one part was control without any Biofield Energy Treatment and another part was treated with the Consciousness Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as Biofield Energy Treated sample. The PXRD analysis demonstrated that both the control and treated samples were amorphous in nature. The particle size values at d 10 , d 50 , and d 90 of the treated sample were decreased significantly by 18.88%, 8.60%, and 4.00%, respectively compared with the control sample. Similarly, the surface area of the treated sample was significantly increased by 102.63% compared to the control sample. FT-IR results suggest that there was a small impact of Biofield Energy Treatment on ashwagandha root extract at the atomic level to reduce the force constant of O-H (str.) bond. UV-vis analysis revealed that the wavelength for the maximum absorbance of the control and treated samples were at 207.4 and 207.7 nm, respectively. TGA revealed the three steps of thermal degradation steps and the total weight loss was decreased by 0.13% in the treated sample compared with the control sample. Consequently, the maximum thermal degradation temperature at 272.73°C and 393.14°C for two broad peaks in treated sample was increased by 1.13% and 0.85%, respectively compared to the control the sample (269.68°C and 389.83°C). DSC analysis indicated that the evaporation temperature and latent heat of vaporization was increased by 1.35% and 5.52%, respectively in the treated sample compared with the control sample. The current findings suggested that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might have the astounding capacity to enhance the solubility, absorption, dissolution, bioavailability and thermal stability of ashwagandha root extract in various form of pharmaceutical and nutraceutical formulation by modifying its particle size and surface area. Thus, the treated ashwagandha root extract might provide better therapeutic response against inflammatory

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Withanolides from Withania somnifera roots

Cited by 141 publications

References 8 publications

Withanolides and Related Steroids

Withanolides and Related Steroids

A Comprehensive Physical, Spectroscopic, and Thermal Characterization of <i>Withania somnifera</i> (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Consciousness Energy Healing Treatment on <i>Withania somnifera</i> Root Extract and Its Effects on the Physical, Spectroscopic, Thermal and Behavioral Properties

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Withanolides from Withania somnifera roots

Cited by 141 publications

References 8 publications

Withanolides and Related Steroids

Withanolides and Related Steroids

A Comprehensive Physical, Spectroscopic, and Thermal Characterization of &lt;i&gt;Withania somnifera&lt;/i&gt; (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;)

Consciousness Energy Healing Treatment on &lt;i&gt;Withania somnifera&lt;/i&gt; Root Extract and Its Effects on the Physical, Spectroscopic, Thermal and Behavioral Properties

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Product

Resources

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A Comprehensive Physical, Spectroscopic, and Thermal Characterization of <i>Withania somnifera</i> (Ashwagandha) Root Extract Treated with the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Consciousness Energy Healing Treatment on <i>Withania somnifera</i> Root Extract and Its Effects on the Physical, Spectroscopic, Thermal and Behavioral Properties