Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice

Mukherjee, Sumedha; Kumar, Gaurav; Patnaik, Ranjana

doi:10.1080/00498254.2019.1709228

Cited by 12 publications

(5 citation statements)

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“…The intranasal administration of W. somnifera and its formulation may have preventative effects against SARS-CoV-2 infections in humans, as the viral entry site at the ACE2 receptor is predominantly distributed on nasal cells, the mucosal surface of the respiratory tract and surrounding the eyes [32]. Intranasal administration of Withanolide A (derived from W. somnifera) delivered an effective amount to the olfactory mucosa to exert a neuroprotective effect in the global cerebral ischemia model [33].…”

Section: Withania Somnifera As a Future Drug Candidate For Covid-19mentioning

confidence: 99%

Withania somnifera as a potential future drug molecule for COVID-19

Kashyap

Dhasmana

Yallapu

et al. 2020

Future Drug. Discov.

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Section: Withania Somnifera As a Future Drug Candidate For Covid-19mentioning

confidence: 99%

Withania somnifera as a potential future drug molecule for COVID-19

Kashyap

Dhasmana

Yallapu

et al. 2020

Future Drug. Discov.

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“…Therefore, this extract can be a promising candidate to prevent neuroinflammation. Withanolide A significantly inhibited cerebral ischemia-induced apoptosis and necrotic cell death, which emphasizes its ability to maintain neural network and cognitive function ( Mukherjee et al, 2020 ) ( Kuboyama et al, 2005 ). Withanolide A also found to prevent hypoxia-induced neurodegeneration through modulation of glutathione biosynthesis ( Baitharu et al, 2014 ).…”

Section: Probable Role Of Withania Somnifera In Covid-19 Pathophysiologymentioning

confidence: 99%

Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management

et al. 2021

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As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional management have highlighted the need for the integration of traditional knowledge systems with modern medicine. Ayurvedic medicines, especially Ashwagandha (Withania somnifera (L.) Dunal, WS), may be beneficial in the management of COVID-19. WS is a widely prescribed Ayurvedic botanical known as an immunomodulatory, antiviral, anti-inflammatory, and adaptogenic agent. The chemical profile and pharmacological activities of WS have been extensively reported. Several clinical studies have reported its safety for use in humans. This review presents a research synthesis of in silico, in vitro, in vivo, and clinical studies on Withania somnifera (L.) Dunal (WS) and discusses its potential for prophylaxis and management of COVID-19. We have collated the data from studies on WS that focused on viral infections (HIV, HSV, H1N1 influenza, etc.) and noncommunicable diseases (hypertension, diabetes, cancer, etc.). The experimental literature indicates that WS has the potential for 1) maintaining immune homeostasis, 2) regulating inflammation, 3) suppressing pro-inflammatory cytokines, 4) organ protection (nervous system, heart, lung, liver, and kidney), and 5) anti-stress, antihypertensive, and antidiabetic activities. Using these trends, the review presents a triangulation of Ayurveda wisdom, pharmacological properties, and COVID-19 pathophysiology ranging from viral entry to end-stage acute respiratory distress syndrome (ARDS). The review proposes WS as a potential therapeutic adjuvant for various stages of COVID-19 management. WS may also have beneficial effects on comorbidities associated with the COVID-19. However, systematic studies are needed to realize the potential of WS for improving clinical outcome of patients with COVID-19.

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“…In this regard, Withania somnifera has emerged as a potential candidate to protect organs against the side effects caused due to the inflammatory reactions of COVID-19. Several studies have reported that the extracts of Withania somnifera containing Withanolide A show neuroprotective candidate against hypoxia-induced and promote cerebral ischemia-induced apoptosis for curing the neurological disorders ( Kuboyama et al., 2005 ; Mukherjee et al., 2020 ). Likewise, extracts of Withania somnifera have shown wonderful response in maintaining elevated levels of cardiac troponin I and IL-6 in the cardiomyopathy condition during the infection ( Adão and Guzik, 2020 ; Ingawale et al., 2020 ).…”

Section: Possible Roles Of Withania Somnifera As I...mentioning

confidence: 99%

“…On the other hand, it has been demonstrated that systemic inflammatory response along with the COVID-19 infection et al, 2005;Mukherjee et al, 2020). Likewise, extracts of Withania somnifera have shown wonderful response in maintaining elevated levels of cardiac troponin I and IL-6 in the cardiomyopathy condition during the infection (Adão and Guzik, 2020;Ingawale et al, 2020).…”

Section: Withania Somnifera Work As a Potent Drug In Combating Covid-19mentioning

confidence: 99%

Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy

Singh

Jayant

Singh

et al. 2022

Front. Cell. Infect. Microbiol.

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Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected by SARS-CoV-2 infection. The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients’ organs. The herbal medicine Withania somnifera has an excellent antiviral activity that could be implicated in the management and treatment of flu and flu-like diseases connected with SARS-CoV-2. The analysis was performed by systematically re-evaluating the published articles related to the infection of SARS-CoV-2 and the herbal medicine Withania somnifera. In the current review, we have provided the important information and data of various bioactive compounds of Withania somnifera such as Withanoside V, Withanone, Somniferine, and some other compounds, which can possibly help in the management and treatment of SARS-CoV-2 infection. Withania somnifera has proved its potential for maintaining immune homeostasis of the body, inflammation regulation, pro-inflammatory cytokines suppression, protection of multiple organs, anti-viral, anti-stress, and anti-hypertensive properties. Withanoside V has the potential to inhibit the main proteases (Mpro) of SARS-CoV-2. At present, synthetic adjuvant vaccines are used against COVID-19. Available information showed the antiviral activity in Withanoside V of Withania somnifera, which may explore as herbal medicine against to SARS-CoV-2 infection after standardization of parameters of drug development and formulation in near future.

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Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice

Cited by 12 publications

References 50 publications

Withania somnifera as a potential future drug molecule for COVID-19

Withania somnifera as a potential future drug molecule for COVID-19

Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management

Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy

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