Withania somnifera  a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy

Ashokkumar, K.; Pandian, Arjun; Baskar, M.; Karthik, M. N.; Murugan, M.; Semwal, Ruchi Badoni; Semwal, Deepak Kumar

doi:10.5604/01.3001.0053.7210

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…Medicinal plants are integral to Earth's biological heritage, offering properties akin to conventional drugs. Utilized in medicine since ancient times, these plants possess antimicrobial qualities that combat the proliferation of microorganisms (Crover et al, 2002;Pandian et al, 2020;Ashokkumar et al, 2021a & b;Ashokkumar et al, 2023;Banso and Ajayai 2023b). Antimicrobial agents play a critical role in treating infectious diseases by either preventing them or treating them at low concentrations without causing harm to the host.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant and bioactive phytochemical properties of Achyranthes aspera L.

Banso,

Dachi,

Ajewole

et al. 2024

J. Current Opinion Crop Sci.,

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Archeranthes aspera, a member of the Amaranthaceae family, is now widely distributed. This species has become invasive in Nigeria. Despite the natural antioxidant defense and repair mechanisms present in humans and other organisms, continuous exposure to free radicals inevitably causes biological harm that cannot be entirely mitigated. In a recent study, extracts of Achyranthes aspera were examined for their secondary metabolites, antioxidant properties, and antibacterial effects against several strains including Staphylococcus aureus (NCIB 8588), Bacillus cereus (NCIB 6349), Klebsiella pneumoniae (NCIB 418), and Pseudomonas aeruginosa (NCIB). Phytochemical analysis of the plant leaf revealed the presence of alkaloids, tannins, general glycosides, and terpenoids. Quantitative analysis of secondary metabolites showed that the plant extract contained 7.0 ± 2.5 mg/100g alkaloids, 11.5 ± 2.0 mg/100g tannins, 15.0 ± 3.1 mg/100g general glycosides, and 14.0 ± 1.5 mg/100g terpenoids. The investigation revealed that the concentration of leaf extract enhanced DPPH scavenging activity, albeit to a lesser extent than ascorbic acid. At concentrations of 50 and 100µg/ml, ascorbic acid exhibited scavenging activities of 22.66 ± 2.34% and 40.55 ± 1.55%, respectively, whereas Achyranthes aspera leaf extract displayed activities of 6.33 ± 2.04% and 11.65 ± 6.18%. Furthermore, the study demonstrated that the plant extract inhibited the growth of bacteria, rendering them vulnerable. The minimum inhibitory concentration of Achyranthes aspera ethanol leaf extract was found to be lowest against S. aureus and highest against B. cereus. These findings suggest that the ingredients present in the plant leaf extract hold promise for potential use in chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant and bioactive phytochemical properties of Achyranthes aspera L.

Banso,

Dachi,

Ajewole

et al. 2024

J. Current Opinion Crop Sci.,

View full text Add to dashboard Cite

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“…Several plant extracts used in traditional medicine are widely available in rural regions, making them cheaper than modern medication (Pandian et al, 2020;Ambiga et al, 2021;Ashokkumar et al, 2021a & b;Ashokkumar et al, 2023). Traditional medicine serves around 60% of rural Nigerians (Apalu et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and antimicrobial activity of Ceiba pentandra against some pathogenic bacteria

Banso,

Ajayi

2023

J. Current Opinion Crop Sci.,

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Many plant ingredients used in traditional medicine are widely available in rural regions, making it cheaper than modern medication. Several secondary metabolites from plants are used to make microbiocides, insecticides, and pharmaceuticals. Ceiba pentandra grows natively in equatorial Africa and other humid tropics, including Nigeria. The agar diffusion method was used to test ethyl acetate, ethanol, and C. pentandra leaf extract against clinical isolates of S. aureus, P. vulgaris, E. coli, and K. pneumoniae. All extracts were antibacterial against test organisms. K. pneumoniae was most vulnerable to plant extracts, and E. coli was most resistant. The plant extracts had a minimum inhibitory concentration of 15 µg/ml to 30 µg/ml against the test organisms. The minimum bactericidal concentrations of extracts ranged from 15 to 35 µg/ml. The ethyl acetate leaf extract of C. pentandra was more efficient than the aqueous or ethanol extract against all test microorganisms. The data may indicate that plant extracts are antibacterial.

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Withania somnifera a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy

Cited by 2 publications

References 78 publications

Evaluation of antioxidant and bioactive phytochemical properties of Achyranthes aspera L.

Evaluation of antioxidant and bioactive phytochemical properties of Achyranthes aspera L.

Phytochemical and antimicrobial activity of Ceiba pentandra against some pathogenic bacteria

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