Wisteria floribunda agglutinin-positive mac-2 binding protein as an age-independent fibrosis marker in nonalcoholic fatty liver disease

Tamaki, Nobuharu; Higuchi, Masakazu; Kurosaki, Masayuki; Kirino, Sakura; Osawa, Leona; Watakabe, Keiya; Wang, Wan; Okada, Mao; Shimizu, Takao; Takaura, Kenta; Takada, Hitomi; Kaneko, Shun; Yasui, Yutaka; Tsuchiya, Kaoru; Nakanishi, Hiroyuki; Itakura, Jun; Takahashi, Yuka; Enomoto, Nobuyuki; Izumi, Namiki

doi:10.1038/s41598-019-46172-1

Cited by 27 publications

(38 citation statements)

References 36 publications

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“…In future research, we must investigate the time-course changes in GEV and WFA+-M2BP caused by antiviral therapy. Further, we only examined patients with chronic hepatitis C. The utility of WFA+-M2BP was proven in chronic hepatitis B, fatty liver disease, and other chronic liver diseases [31][32][33][34]. The cut-off value for stratifying the fibrosis stage differs depends on the etiology [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

et al. 2020

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Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. Results: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA + -M2BP) levels increased according to the grade of GEV (3.4 (0.2-18.6) for no GEV, 7.9 (1.8-20.0) for small GEV, and 11.4 (4.0-20.0) for large GEV; p < 0.001). The diagnostic accuracy of the WFA + -M2BP was superior compared to other serum fibrosis markers, and WFA + -M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA + -M2BP levels ≤ 7.0 and 37.5% in patients with WFA + -M2BP levels > 7.0 (p < 0.001). WFA + -M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7, p = 0.004) independent of Child-Pughclass. Conclusions: WFA + -M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.

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Section: Discussionmentioning

confidence: 99%

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

et al. 2020

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“…M2BPGi, a novel hepatic fibrosis marker, has been developed in Japan. M2BPGi can predict fibrosis stage in CLD, including NAFLD [ 115 , 116 , 117 ]. In the Korean population with CLD, sequential combination of FIB-4 index followed by M2BPGi can identify advanced fibrosis (≥F3) evaluated by MRE [ 113 ].…”

Section: Two-step Algorithm In Nafld Diagnosismentioning

confidence: 99%

Epidemiology, Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan

Sumida

Shima

Mitsumoto

et al. 2020

IJMS

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Type 2 diabetes (T2D) is closely associated with nonalcoholic fatty liver disease (NAFLD). Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can lead to cirrhosis, hepatocellular carcinoma (HCC), and hepatic decompensation. Patients with T2D have twice the risk of HCC incidence compared with those without T2D. Because the hepatic fibrosis grade is the main determinant of mortality in patients with NAFLD, identifying patients with advanced fibrosis using non-invasive tests (NITs) or imaging modalities is crucial. Globally, the fibrosis-4 index (FIB-4 index), NAFLD fibrosis score, and enhanced liver fibrosis test have been established to evaluate hepatic fibrosis. Two-step algorithms using FIB-4 index as first triaging tool are globally accepted. It remains unknown which kinds of NITs or elastography are best as the second step tool. In Japan, type IV collagen 7s or the CA-fibrosis index (comprising type IV collagen 7s and aspartate aminotransferase (AST)) is believed to precisely predict advanced fibrosis in NAFLD. Patients with NAFLD who have high non-invasive test results should be screened for HCC or esophageal varices. Risk factors of rapid fibrosis progression in NAFLD includes age, severe obesity, presence of T2D, menopause in women, and a patatin-like phospholipase domain containing the 3 GG genotype. Patients with NAFLD who have these risk factors should be intensively treated with lifestyle modification or pharmacotherapies for preventing liver-related mortality.

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“…Galectin-3 binding protein (Gal-3BP), one of the major fucosylated glycoprotein family members, appears to be implicated in the immune response and in cytotoxicity [3,4]. Recently, several clinical investigations have suggested that Gal-3BP is related to metabolic dysfunctions ranging from nonalcoholic fatty liver disease to atherosclerosis [5][6][7]. However, few studies have focused on the relationship between insulin resistance and Gal-3BP, and the results remain controversial [8,9].…”

Section: Introductionmentioning

confidence: 99%

Elevated serum levels of galectin-3 binding protein is associated with insulin resistance in non-diabeteic women after menopause

Chen

Das

Zhuo

et al. 2020

Preprint

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Background Galectin-3 binding protein (GAL-3BP) is one of the major fucosylated glycoprotein family members, and is implicated in nonalcoholic fatty liver disease, lipid dysfunctions and coronary artery disease recently. Here we analyzed the serum concentrations of GAL-3BP in postmenopausal women, to evaluate the association of circulating GAL-3BP and insulin resistance in female after menopause.Method We evaluated serum levels of Gal-3BP in sixty-two non-diabetic women in menopausal status for at least one year. The clinical features, biochemistry profiles and homeostasis model assessment of insulin resistance (HOMA-IR) were obtained routinely.Results Gal-3BP levels increased in women with higher HOMA-IR values and was positively correlated to HOMA-IR. It was also an independent risk factors for HOMA-IR and showed the most influence on HOMA-IR comparing to FPG, TG, age and BMI. The cut-off value of serum Gal-3BP level was 2234.3150 ng/ml with the area under the ROC curve (AUC) 0.68 (HOMA-IR 1.5), 0.81 (HOMA-IR 2.0) and 0.93 (HOMA-IR 2.5).Conclusions Serum levels of Gal-3BP is associated with impaired insulin sensitivity in non-diabetic menopausal women.

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Wisteria floribunda agglutinin-positive mac-2 binding protein as an age-independent fibrosis marker in nonalcoholic fatty liver disease

Cited by 27 publications

References 36 publications

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

Epidemiology, Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan

Elevated serum levels of galectin-3 binding protein is associated with insulin resistance in non-diabeteic women after menopause

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