Wirkungen von Psychopharmaka auf das Explorationsverhalten von M�usen

Minck, Klaus-Otto; Danneberg, P; Knappen, F

doi:10.1007/bf00421032

Cited by 17 publications

(4 citation statements)

References 19 publications

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“…Therefore, ambulatory activity can be used as a measure of behavioral indices for locomotion in mice. This notion is further supported by results of the previous [91–93] and present studies that show the ambulatory activity of ICR (CD-1) mice was stimulated by psychostimulants such as BUP and MP, which have been known to stimulate mouse locomotion [94–99], and reduced by depressants such as HAL and FLU, which have been known to reduce mouse locomotion [98, 100–102]. …”

Section: Discussionsupporting

confidence: 87%

Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

Umezu

2012

ISRN Pharmacology

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The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate. ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered. This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice. Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine. Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice.

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Section: Discussionsupporting

confidence: 87%

Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

Umezu

2012

ISRN Pharmacology

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“…The lack of effect of valerian on rearing and locomotion is also in contrast to diazepam; the latter drug, in low non-sedative doses, reduces rearing and increases locomotion (Figs 1 and 4) as a consequence of lessened anxiety (Minck et al, 1974;Thitbot et al, 1976;SoubriC et al, 1977;Simiand et al, 1984;Rago et al, 1988). We may conclude that valerian does not exert the same type of antianxiety effect as diazepam.…”

Section: Neuropharmacology Ofmentioning

confidence: 87%

Neuropharmacological Studies on Ethanol Extracts ofValeriana officinalisL.: Behavioural and Anticonvulsant Properties

Hiller¹,

Zetler

1996

Phytother. Res.

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An ethanol total extract of the roots of Valeriana officinalis L. in doses equivalent to 0.5–800 mg valerian root/kg b.w.i.p. was tested in male mice for possible neuropharmacological efficacy and in this respect compared with diazepam and haloperidol. The extract did not modify spontaneous motility, nociception or body temperature, and did not produce palpebral ptosis. However, it was anticonvulsant against picrotoxin (but not pentetrazol and harman) with an ED50 between 4.5 and 6 mg/kg and it prolonged thiopental anaesthesia. After fractionation of the crude extract, the antipicrotoxin activity was present mainly in the methylene chloride fraction (ED50=0.25 mg/kg). Pure valerenic acid (12.5 mg/kg b.w.i.p.) also exerted an antipicrotoxin effect.

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“…There are two possible explanations for this discrepancy. The holes drilled through the SAP plastic platform are small (1 cm diameter) compared to the large holes drilled (3 cm diameter) in the currently used hole-boards (Dorr et al 1971;Minck et al 1974). Thus, the stimuli releasing head dipping may be different.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the stimuli releasing head dipping may be different. Furthermore, in the present study low oral doses (up to I mg/kg) were administered, whereas in the hole-board situations, a decrease of head-dipping was apparent in mice only after much higher oral dosage (7.5 mg/kg, Minck et al 1974) and in rats after IP injection of >2mg/kg (File 1973). Therefore, apart from using a lower dose range, methodological differences (i.e.…”

Section: Discussionmentioning

confidence: 99%

Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action

Kaesermann¹

1986

Psychopharmacology

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Based upon the ethological element "stretched attend" to a conspecific, which reflects ambivalence between approach and avoidance in a social context, a simple, non-social behavioral method for studying conflict behavior in mice was investigated. Thus, stretched attend posture (SAP) and other behavioral acts were measured in untreated or drug-treated mice which were individually placed on a perforated platform previously rubbed with foreign male urine and boluses. In naive, untreated mice, the occurrence of SAP was partly housing- and lighting-dependent. After repeated exposure to the test situation, untreated mice showed less SAP, whereas static behavior (immobility and activity at rest) was increased. After single oral treatment with diazepam, clobazam or phenobarbital, SAP was reduced, whereas static behavior or "going forwards in SAP" was increased. Chlorpromazine and imipramine did not influence SAP. In naive mice, single IP injection of pentylenetetrazol did not significantly increase SAP. The similarity in the behavioral response between experienced, untreated mice and naive animals treated with diazepam, clobazam, or phenobarbital suggests that drug-treated mice behaved as if they were already familiar with the test situation. The latter drug-induced changes are consistent with data obtained in animal models which are based upon the measurement of behavioral inhibition. Under the present test conditions, pentylenetetrazol did not show "anxiogenic" properties. Nevertheless, the SAP test, based primarily on the measurement of the ambivalence element, offers a simple procedure for examining the conflict-reducing properties of drugs, dispensing with the need of noxious stimuli or prior training.

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Wirkungen von Psychopharmaka auf das Explorationsverhalten von M�usen

Cited by 17 publications

References 19 publications

Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

Neuropharmacological Studies on Ethanol Extracts ofValeriana officinalisL.: Behavioural and Anticonvulsant Properties

Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action

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