Wirkung yon Pharmaka und Milieuänderungen auf die Flimmertätigkeit der Atemwege

Iravani, J.; Melville, G.N.

doi:10.1159/000193645

Cited by 61 publications

(15 citation statements)

References 2 publications

(5 reference statements)

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“…The PDE4 inhibitor roflumilast increases cilia beat frequency in vitro and reverses the decrease in cilia beat frequency observed with treatment with cigarette smoke extract (180). The cholinergic agents acetylcholine and pilocarpine increase cilia beat frequency (181) and conversely, anticholinergic drugs reduce cilia beat frequency (182). Topical application of corticosteroids to airway epithelium in culture results in a small increase in cilia beat frequency (181).…”

Section: Acquired Disorders Of Airway Ciliamentioning

confidence: 99%

“…The cholinergic agents acetylcholine and pilocarpine increase cilia beat frequency (181) and conversely, anticholinergic drugs reduce cilia beat frequency (182). Topical application of corticosteroids to airway epithelium in culture results in a small increase in cilia beat frequency (181). Prolonged inhaled steroid treatment in asthmatics has been shown to reverse epithelial damage seen in the same subjects prior to steroid treatment, including areas of epithelium that showed loss of cilia (183).…”

Section: Acquired Disorders Of Airway Ciliamentioning

confidence: 99%

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Cilia Dysfunction in Lung Disease

Tilley

Walters²,

Shaykhiev³

et al. 2015

Annu. Rev. Physiol.

342

308

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A characteristic feature of the human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell surface projections containing axonemes comprised of microtubules and dynein arms, which provide ATP-driven motility. In the airways, cilia function in concert with airway mucus to mediate the critical function of mucociliary clearance, cleansing the airways of inhaled particles and pathogens. The prototypical disorder of respiratory cilia is primary ciliary dyskinesia, an inherited disorder that leads to impaired mucociliary clearance, repeated chest infections, and progressive destruction of lung architecture. Numerous acquired lung diseases are also marked by abnormalities in both cilia structure and function. In this review we summarize current knowledge regarding airway ciliated cells and cilia, how they function to maintain a healthy epithelium, and how disorders of cilia structure and function contribute to inherited and acquired lung disease.

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Section: Acquired Disorders Of Airway Ciliamentioning

confidence: 99%

Section: Acquired Disorders Of Airway Ciliamentioning

confidence: 99%

Cilia Dysfunction in Lung Disease

Tilley

Walters²,

Shaykhiev³

et al. 2015

Annu. Rev. Physiol.

342

308

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“…The periciliary sol phase immediately apposed to the epithelial surface consists of inter cellular fluid [Lucas and Douglas, 1934;Iravani and Melville, 1975], The cilia beat in this fluid secretion layer ( fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Morphological Features of the Interaction Between Mucus and Surfactant on the Bronchial Mucosa

Morgenroth

Bolz²

1985

Respiration

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The secretion layer over the bronchial epithelium was investigated on human biopsy material. In the sol phase of the secretion, phospholipid membranes stretched out or arranged in vesicular structures could regularly be demonstrated. They displayed the same structure as the surfactant material in the alveolar space. It can be inferred therefrom that the surfactant is excreted via the bronchial system. It probably contributes to the stabilization of the sol phase of the mucus and thus influences the sliding capacity of the gel phase. So the surfactant has an important function in maintaining mucociliary clearance at the bronchial mucosa.

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“…The consequent obstruction of the bronchial lumen facilitates the colonization of patho genic agents and bacterial superinfections in the airways, leading to the onset and progression of chronic inflamma tion [4], The aim of therapy is therefore not only to elimi nate the factors irritating the lungs, but also to restore the impaired mucociliary function in order to prevent the pro gression of the chronic inflammatory condition. It has been demonstrated that methylxanthines improve muco ciliary transport by acting on the ciliary stroke frequency and on the rheological features of the mucus [5][6][7],…”

mentioning

confidence: 99%

Effect of Bamiphylline on Tracheobronchial Mucus Clearance in Subjects with Smokers’ Simple Chronic Bronchitis

Todisco¹,

Baglioni²,

Eslami³

et al. 1995

Respiration

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A double-blind study versus placebo was performed to assess the effect of bamiphylline, a new xanthylic derivative, on tracheobronchial mucus clearance (TBMC) in smokers with simple chronic bronchitis and impaired mucus clearance as compared to normal controls. Twenty patients were enrolled and divided into two randomized groups. The first group was treated with bamiphylline (600 mg b.d.) for 15 days, while the second group received placebo with the same oral dosage regimen. Complete clinical-functional examinations were made before and after the test period to establish the effects of treatment. At the end of the study, only the group treated with bamiphylline showed a net increase in mucus clearance (mean radioaerosol elimination 28 ± 7% before treatment and 38 ± 11 % after treatment; p < 0.01) and an improvement in the clinical score and pulmonary function parameters, in particular the residual volume (RV = 3.41 ± 0.75 liters before treatment and 2.7 ± 0.6 after treatment; p < 0.01) and the forced expiratory volume at 1 s (FEV₁ = 2.37 ± 0.7 liters before treatment and 2.88 ± 0.5 after treatment; p < 0.05). No side effects or adverse reactions that could be attributed to the study drug were observed.

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Wirkung yon Pharmaka und Milieuänderungen auf die Flimmertätigkeit der Atemwege

Cited by 61 publications

References 2 publications

Cilia Dysfunction in Lung Disease

Cilia Dysfunction in Lung Disease

Morphological Features of the Interaction Between Mucus and Surfactant on the Bronchial Mucosa

Effect of Bamiphylline on Tracheobronchial Mucus Clearance in Subjects with Smokers’ Simple Chronic Bronchitis

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