Wirkung des Detergens Metaupon auf die Vermehrung verschiedener Phagen

Menzel, G.; Stenz, E.

doi:10.1002/jobm.3630190504

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Therefore, this property may be one of the reasons for the phage-inactivating action of a range of surface-active substances, such as polyethylene glycol monoesters, polyoxyethylene alkyl ethers, Tween 20 and 60, which are preferably applied in concentrations of 0.01-0.2% [31, 47, 1401. Metaupon, a sulfonic acid derivative, was also found to be an efficient phage inhibitor [141]. Unfortunately, most detergents which are active against phages are also toxic for the bacterial host strains.…”

Section: Employment Of Phage Inhibitorsmentioning

confidence: 99%

Importance of bacteriophages in fermentation processes

Wünsche

1989

Acta Biotechnologica

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Any bacterial strain can be infected by virulent phages or harbour one or more prophages. Therefore, bacteria-phage interactions are to be regarded as fundamental properties of bacteria. In current industrial fermentation processes phages can be advantageously employed for the identification of bacterial production strains (phage typing). In some cases phages are involved in the production of enzymes and special substances. The fundamental importance of phages in any technical fermentation process, however, is based on the peculiarities of their obligately parasitic life cycle. The propagation of phages in fermentation processes can cause complete (or a t least partial) lysis of the production strains and, consequently, serious disturbances in the production process and considerable economic losses. The phage problem in the fermentation industry has not yet been completely solved. For the protection of technical processes against virulent phages five measures are discussed: phage-protected sterile fermentation, employment. of alternative cultures, employment of phage-resistant mutants. employment of phage inhibitors, and employment of immobilized bacterial cells. The problem of the protection of bacterial production strains from prophage induction is more difficult and practically unsolved. Two possibilities to minimize the process risk due to temperate phages, the elimination of inducing factors during the fermentation process, and the selection of production strains which are difficult to induce, are discussed.

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Section: Employment Of Phage Inhibitorsmentioning

confidence: 99%

Importance of bacteriophages in fermentation processes

Wünsche

1989

Acta Biotechnologica

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Inhibierung der Entwicklung von Bakteriophagen in Fermentationsprozessen durch Zusatz von Kohlenwasserstoffen

Wünsche¹,

Kiesel²

1981

Acta Biotechnologica

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The propagation of the virulent phage M 1 of the obligate methylotrophic bacteria strain GB 4 is inhibited by n‐alkanes. The addition of hydrocarbons (7.5–22.5%) to a suspension of free phages or to a phage‐host‐mixture prevents the propagation of the phages, but does not influence the growth rate of the host bacteria. In a laboratory fermentor a simulated strong infection (multiplicity = 0.1) of the strain GB 4 with its phage M 1 could be suppressed by the application of 20% of a technical hydrocarbon mixture (Parex I).The inhibitory effect of the hydrocarbons can be traced back to inspecific hydrocarbon‐protein‐interactions at the surface of the phage and the host cells and therewith to an influencing of the adsorption.

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Geförderte Plaquebildung in RNA‐Phagen/Bakterien‐Systemen unter dem Einfluß oberflächenaktiver Präparate

Menzel

1985

J. Basic Microbiol.

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The effect of 21 surfactants on the plaque formation was tested in three RNA-phages/Escherichia coli systems and in one RNA-phage/Pseudomonas aeruginosa system. Especially anionic detergents proved to be able to influence the plaque formation substantially. In high concentrations of Metaupon, Fekunil 602, Fekunil S-BA, Emulgator W 270, and Emulgator O-BA the plaque formation by the phages M 12 and f2 was inhibited and in low concentrations it was promoted. In the system Q beta/E. coli AB 301 the effect of the detergents mentioned was restricted to the prevention of the appearance of plaques. The detergent E 30 brought about only plaque inhibitions, too, in all used RNA-phages/E. coli systems. The treatment with effective detergents in the system PP7/P. aeruginosa, however, increased only the number of plaques. This phenomenon was evident in the formation of radiate plaque patterns in the lawn of bacteria. In the case of RNA-phages of E. coli the formation of such trains of lysis depends on the choice of the nutritive medium. The addition of the detergent Fekunil 602 at different times after the contact between phages and host bacteria affects the length of the beams of lysis. The ionogenity of surfactants seems to be of importance for the formation of radiate plaque patterns, since the tested cationic compound and the nonionic surfactants, contrary to anionic surfactants, did not cause any beams of lysis.

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Wirkung des Detergens Metaupon auf die Vermehrung verschiedener Phagen

Cited by 4 publications

References 21 publications

Importance of bacteriophages in fermentation processes

Importance of bacteriophages in fermentation processes

Inhibierung der Entwicklung von Bakteriophagen in Fermentationsprozessen durch Zusatz von Kohlenwasserstoffen

Geförderte Plaquebildung in RNA‐Phagen/Bakterien‐Systemen unter dem Einfluß oberflächenaktiver Präparate

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