Wirksamkeit von Vitamin E im Vergleich zu Diclofenac-Natrium in der Behandlung von Patienten mit chronischer Polyarthritis

Wittenborg, A; Petersen, Greta; Lorkowski, G; Brabant, T.

doi:10.1007/s003930050094

Cited by 27 publications

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“…[ 17 ] It is also scientifically proved to possess anti-inflammatory, immunomodulatory, vascular protective, and sex hormone modulator effects. [ 18 19 20 ] In vitro antioxidant activity of the aqueous extract of date fruit is demonstrated in many studies based on its phenolic compounds with potent free radical scavenging activity. [ 21 22 ] The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in vivo , in an experimental testicular torsion/detorsion (T/D) model in rats.…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

et al. 2017

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Background:Antioxidants are potent scavengers of free radicals and have beneficial effects on human health.Objective:The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in an experimental testicular torsion/detorsion (T/D) model in rats.Materials and Methods:To investigate the potential protective effects of date palm (DP), 30 male Spraque-Dawley rats were divided into three groups: sham-operated, T/D, and T/D + DP-treated (500 mg/kg, PO) groups. Testicular ischemia was induced via keeping the left testis under 720° clockwise torsion for 2 h (h), afterward, detorsion was performed. All rats were sacrificed 4 h after detorsion. Serum malondialdehyde (MDA) concentration, total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and histopathological damage score were evaluated.Results:Serum MDA, TOS, and OSI levels rose significantly in the T/D group. These values were lower in the T/D + DP group. TAS values decreased significantly in T/D group and rose in T/D + DP group. Severe injury was seen in the twisted testes of T/D group. In contrast, ipsilateral-twisted testicular tissue in the DP-treated group showed moderate-to-mild changes. Contralateral testicular tissue in the T/D group had a mild-to-moderate tissue injury; meanwhile, treated group revealed normal-to-mild changes. Spermatogenesis was significantly improved in DP-treated group when compared with the T/D group.Conclusion:The findings suggest a possible protective effect of DP against testicular oxidative damage induced by T/D; however, more detailed studies are warranted.SUMMARYGiven the presence of several phenolic compounds possessing high antioxidant activity in DP, it could potentially be used to reduce testis ischemia/reperfusion-induced damage.Abbreviations Used: TAS: Total antioxidant status,TOS: Total oxidative status; OSI: Oxidative stress index; MDA: Malondialdehyde; C: Congestion; H: Hemorrhage, E: Edema; SG: Sloughed germinal cells; SA: Spermatogenesis arrest; STD: Seminiferous tubules disorganization; STA: Seminiferous tubules atrophy; G: Giant cells; T/D: Torsion/detorsion; DP: Date palm

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Section: Introductionmentioning

confidence: 99%

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

et al. 2017

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“…Vitamin E level was lower in the patients than in the controls in that study arguing oxygen free radicals and oxidative reactions contributed to developing osteoarthritis ( 31 ). Also, the role of vitamin E in treating chronic polyarthritis symptoms was well demonstrated in Wittenborg et al study ( 32 ).…”

Section: Discussionmentioning

confidence: 78%

Comparative Effectiveness of B and E Vitamins with Diclofenac in Reducing Pain Due to Osteoarthritis of the Knee

Dehghan

2015

Med Arh

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Background:Knee osteoarthritis is one of the most prevalent chronic disorders. Several pharmacological and non pharmacological approaches are used to treat this disease. Today, the effect of B and E vitamins on rheumatology diseases is being discussed. In this study, the efficacy of B and E vitamins accompanied with diclofenac on pain relief in patients with knee osteoarthritis was investigated and compared.Methods:In this double-blinded clinical trial, 120 patients with knee osteoarthritis referring training Rheumatology and Orthopedics Clinic of Shahrekord University of Medical sciences were investigated. Of these patients, 12 were excluded throughout the study. The patients underwent treatment in three groups (oral diclofenac + oral B vitamin, oral diclofenac + oral vitamin E, and oral diclofenac + placebo). Pain relief was assessed by visual analogue scale (VAS) questionnaire and morning stiffness and physical function were assessed by WOMAC standard questionnaire at three times; the first examination, two weeks, and three weeks after referring.Results:The mean score of WOMAC questionnaire at VASs of knee pain, total pain severity, knee joint stiffness, and function of the last 48 hours decreased significantly in all three groups (diclofenac, E and B vitamins) from the first to third examination (P<0.001). Decrease in VAS of knee pain and function of the last 48 hours was higher in B vitamin group than the diclofenac and E vitamin group (P=0.008) and decrease in total pain severity was reported higher in B vitamin group than E vitamin and diclofenac group (P=0.019). Decrease in knee joint stiffness underwent a similar trend in the three groups.Conclusion:In view similar analgesic and anti-inflammatory properties, as well as very few, non prevalent complications of B and E vitamins, use of two or more drugs with a different mechanism of effect seems necessary to enhance their effect on osteoarthritis treatment.

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“…Four RCTs [18,24,25,44,46] did not describe the implementation process of blinding, and the indicators of this study are biochemical indicators (such as MDA); they are assessed as low risk of bias. Twelve (12) RCTs [20,28,29,34,[36][37][38][39][40][41][42][43]45] claimed to use blinding but did not describe the implementation process of blinding Oxidative Medicine and Cellular Longevity and included subjective indicators (such as DAS28 and VAS), so they were assessed as unclear risk of bias. Two RCTs [30,35] did not utilize blinding, and the indicators of this study are subjective indicators (such as VAS and DAS28); they are assessed as high risk of bias.…”

Section: Blinding Incomplete Outcome Data and Selectivementioning

confidence: 99%

The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

Zeng

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Objective. To explore the efficacy of antioxidative stress therapy on oxidative stress levels in rheumatoid arthritis (RA) by a systematic review and meta-analysis of randomized controlled trials. Methods. Chinese and English databases such as PubMed, Embase, China National Knowledge Infrastructure (CNKI), and China Biomedical Literature were searched, mainly searching for clinical randomized controlled trials of antioxidant therapy for rheumatoid arthritis. The search time is from the establishment of the database to July 2021. Two researchers independently carried out literature search, screening, and data extraction. The bias risk tool provided by the Cochrane Collaboration was used to evaluate the bias risk of all the included literature, and the RevMan 5.3 software was used for meta-analysis. Results. A total of 24 RCTs (28 records) and 1277 participants were included. The time span of randomized controlled trials (RCTs) is from 1986 to 2020. These RCTs involve 14 types of antioxidants or antioxidant therapies, and these therapies have varying degrees of improvement on oxidative stress in RA patients. The summary results showed that the MDA in the experiment group is lower (SMD -0.82, 95% CI -1.35 to -0.28, P = 0.003 ). The difference of TAC, SOD, NO, GPx, CAT, and GSH between two groups was of no statistical significance (TAC (SMD 0.27, 95% CI -0.21 to 0.75, P = 0.27 ), SOD (SMD 0.12, 95% CI -0.16 to 0.40, P = 0.41 ), NO (SMD -2.03, 95% CI -4.22 to 0.16, P = 0.07 ), GPx (SMD 0.24, 95% CI -0.07 to 0.54, P = 0.13 ), CAT (SMD 2.95, 95% CI -2.6 to 8.51, P = 0.30 ), and GSH (SMD 2.46, 95% CI -0.06 to 4.98, P = 0.06 )). For adverse events, the summary results showed that the difference was of no statistical significance (RR 1.16, 95% CI 0.79 to 1.71, P = 0.45 ). In addition, antioxidant therapy has also shown improvement in clinical efficacy indexes (number of tender joints, number of swollen joints, DAS28, VAS, and HAQ) and inflammation indexes (ESR, CRP, TNF-α, and IL6) for RA patients. Conclusion. The existing evidence shows potential benefits, mainly in reducing MDA and increasing TAC and GSH in some subgroups. However, more large samples and higher quality RCTs are needed to provide high-quality evidence, so as to provide more clinical reference information for the antioxidant treatment of RA.

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Wirksamkeit von Vitamin E im Vergleich zu Diclofenac-Natrium in der Behandlung von Patienten mit chronischer Polyarthritis

Cited by 27 publications

References 4 publications

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats

Comparative Effectiveness of B and E Vitamins with Diclofenac in Reducing Pain Due to Osteoarthritis of the Knee

The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

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