Wirksamkeit einer klassisch-homöopathischen Therapie bei atopischem Ekzem

Siebenwirth, J.; Lüdtke, Rainer; Remy, W.; Rakoski, J.; Borelli, Siegfried; Ring, Johannes

doi:10.1159/000242434

Cited by 23 publications

(8 citation statements)

References 24 publications

(10 reference statements)

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“…A classical randomized placebo‐controlled trial was initiated in Germany including 60 patients 136 . There was no difference between placebo and verum homoeopathy in the outcome of AE 137 …”

Section: Complementary and Alternative Medicine In Atopic Eczemamentioning

confidence: 79%

Guidelines for treatment of atopic eczema (atopic dermatitis) Part II

Ring

Alomar

Bieber

et al. 2012

Acad Dermatol Venereol

348

343

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The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation. The consensus process consisted of a nominal group process and a DELPHI procedure. Management of AE must consider the individual symptomatic variability of the disease. Basic therapy is focused on hydrating topical treatment, and avoidance of specific and unspecific provocation factors. Anti-inflammatory treatment based on topical glucocorticosteroids and topical calcineurin inhibitors (TCI) is used for exacerbation management and more recently for proactive therapy in selected cases. Topical corticosteroids remain the mainstay of therapy, but the TCI tacrolimus and pimecrolimus are preferred in certain locations. Systemic immune-suppressive treatment is an option for severe refractory cases. Microbial colonization and superinfection may induce disease exacerbation and can justify additional antimicrobial treatment.Adjuvant therapy includes UV irradiation preferably with UVA1 wavelength or UVB 311 nm. Dietary recommendations should be specific and given only in diagnosed individual food allergy. Allergen-specific immunotherapy to aeroallergens may be useful in selected cases. Stress-induced exacerbations may make psychosomatic counselling recommendable. 'Eczema school' educational programs have been proven to be helpful.Pruritus is targeted with the majority of the recommended therapies, but some patients need additional antipruritic therapies.

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Section: Complementary and Alternative Medicine In Atopic Eczemamentioning

confidence: 79%

Guidelines for treatment of atopic eczema (atopic dermatitis) Part II

Ring

Alomar

Bieber

et al. 2012

Acad Dermatol Venereol

348

343

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“…Zajecka et al [28] had 511/1184 = 43%), this study highlights recruitment problems in placebo-controlled trials on homeopathy, also seen to be the case in other homeopathy trials. For example, in a placebo-controlled trial on classical homeopathy for patients with atopic dermatitis, Siebenwirth et al were able to include only 24 of 746 screened patients because of narrow eligibility criteria [29]. In a trial on depression in the general practice setting in UK, Katz et al expected over 230 suitable patients during the recruitment phase, but only 31 patients were referred for possible inclusion in the trial.…”

Section: Discussionmentioning

confidence: 99%

Homeopathy for Depression: A Randomized, Partially Double-Blind, Placebo-Controlled, Four-Armed Study (DEP-HOM)

et al. 2013

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BackgroundThe specific clinical benefit of the homeopathic consultation and of homeopathic remedies in patients with depression has not yet been investigated.AimsTo investigate the 1) specific effect of individualized homeopathic Q-potencies compared to placebo and 2) the effect of an extensive homeopathic case taking (case history I) compared to a shorter, rather conventional one (case history II) in the treatment of acute major depression (moderate episode) after six weeks.MethodsA randomized, partially double-blind, placebo-controlled, four-armed trial using a 2×2 factorial design with a six-week study duration per patient was performed.ResultsA total of 44 from 228 planned patients were randomized (2∶1∶2∶1 randomization: 16 homeopathic Q-potencies/case history I, 7 placebo/case history I, 14 homeopathic Q-potencies/case history II, 7 placebo/case history II). Because of recruitment problems, the study was terminated prior to full recruitment, and was underpowered for the preplanned confirmatory hypothesis testing. Exploratory data analyses showed heterogeneous and inconclusive results with large variance in the sample. The mean difference for the Hamilton-D after 6 weeks was 2.0 (95%CI −1.2;5.2) for Q-potencies vs. placebo and −3.1 (−5.9;−0.2) for case history I vs. case history II. Overall, no consistent or clinically relevant results across all outcomes between homeopathic Q-potencies versus placebo and homeopathic versus conventional case taking were observed. The frequency of adverse events was comparable for all groups.ConclusionsAlthough our results are inconclusive, given that recruitment into this trial was very difficult and we had to terminate early, we cannot recommend undertaking a further trial addressing this question in a similar setting.Prof. Dr. Claudia Witt had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.Trial registrationclinicaltrials.gov identifier NCT01178255. Protocol publication: http://www.trialsjournal.com/content/12/1/43

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“…A recent uncontrolled trial of 17 patients with longstanding AE in Japan revealed a marked improvement after the introduction of homoeopathic treatment . A classical randomized placebo‐controlled trial was initiated in Germany including 60 patients, showing no difference between placebo and verum homeopathy in the outcome of AE …”

Section: Complementary and Alternative Medicine In Atopic Eczemamentioning

confidence: 99%

“…192 A classical randomized placebo-controlled trial was initiated in Germany including 60 patients, 193 showing no difference between placebo and verum homeopathy in the outcome of AE. 194…”

Section: Recommendationsmentioning

confidence: 99%

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

Wollenberg

Barbarot

Bieber

et al. 2018

Acad Dermatol Venereol

583

717

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This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This second part of the guideline covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions, whereas the first part covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy. Management of AE must consider the individual clinical variability of the disease. Systemic immunosuppressive treatment with cyclosporine, methotrexate, azathioprine and mycophenolic acid is established option for severe refractory cases, and widely available. Biologicals targeting the T helper 2 pathway such as dupilumab may be a safe and effective, disease-modifying alternative

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Wirksamkeit einer klassisch-homöopathischen Therapie bei atopischem Ekzem

Cited by 23 publications

References 24 publications

Guidelines for treatment of atopic eczema (atopic dermatitis) Part II

Guidelines for treatment of atopic eczema (atopic dermatitis) Part II

Homeopathy for Depression: A Randomized, Partially Double-Blind, Placebo-Controlled, Four-Armed Study (DEP-HOM)

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

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