Wiring Economy and Volume Exclusion Determine Neuronal Placement in the Drosophila Brain

Rivera-Alba, Marta; Vitaladevuni, Shiv; Mishchenko, Yuriy; Lǚ, Zhiyuan; Takemura, Shin-ya; Scheffer, Lou; Meinertzhagen, Ian A.; Chklovskii, Dmitri B.; Polavieja, Gonzalo G. de

doi:10.1016/j.cub.2011.12.055

Cited by 13 publications

(42 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incoming photoreceptor axon bundles from 800 ommatidia connect to 800 lamina columns, in which complex synaptic connections are made between six photoreceptors (R1-R6), five lamina output neurons (L1-L5; Fig. 9A.2) and additional higher order neurons (Fischbach, 1989;Meinertzhagen, 1993;Rivera-Alba et al, 2011;Tuthill et al, 2013). Previous studies in Musca and Drosophila have identified six types of glial cells, which are organized in distinct layers: fenestrated, pseudo-cartridge, distal and proximal satellite, epithelial and marginal glia (Edwards et al, 2012;Saint Marie and Carlson, 1983a,b), for review: Edwards and Meinertzhagen (2010).…”

Section: The Laminamentioning

confidence: 99%

The glia of the adult Drosophila nervous system

Kremer

Jung

Batelli

et al. 2017

Glia

233

363

View full text Add to dashboard Cite

Glia play crucial roles in the development and homeostasis of the nervous system. While the GLIA in the Drosophila embryo have been well characterized, their study in the adult nervous system has been limited. Here, we present a detailed description of the glia in the adult nervous system, based on the analysis of some 500 glial drivers we identified within a collection of synthetic GAL4 lines. We find that glia make up ∼10% of the cells in the nervous system and envelop all compartments of neurons (soma, dendrites, axons) as well as the nervous system as a whole. Our morphological analysis suggests a set of simple rules governing the morphogenesis of glia and their interactions with other cells. All glial subtypes minimize contact with their glial neighbors but maximize their contact with neurons and adapt their macromorphology and micromorphology to the neuronal entities they envelop. Finally, glial cells show no obvious spatial organization or registration with neuronal entities. Our detailed description of all glial subtypes and their regional specializations, together with the powerful genetic toolkit we provide, will facilitate the functional analysis of glia in the mature nervous system. GLIA 2017 GLIA 2017;65:606–638

show abstract

Section: The Laminamentioning

confidence: 99%

The glia of the adult Drosophila nervous system

Kremer

Jung

Batelli

et al. 2017

Glia

233

363

View full text Add to dashboard Cite

show abstract

“…In Video S10, we construct a cartridge of the Lamina neuropil. The complete shape of neurons and connectivity between neurons in a single cartridge of the lamina have been determined by serial electron microscopy [13]. Using NeuroGFX, we visualize side by side both the morphology The neural circuit configuration, manipulation and composition capabilities in NeuroGFX are a significant step towards providing design automation tools for computational neuroscience.…”

Section: From Fruit Fly Brain Structure To Function With Neurogfxmentioning

confidence: 99%

“…On the local circuit level, the focus of NeuroGFX is to explore the function of a circuit of manageable size, e.g., a canonical circuit in an LPU, thereby facilitating the understanding of the basic building blocks of their respective LPUs. The complete shape of neurons and connectivity between neurons in a single cartridge of the lamina have been determined by serial electron microscopy [13]. The circuit diagram of the cartridge is created according to the connectome data.…”

Section: Visualization Enginementioning

confidence: 99%

“…This can be accessed in https://neurogfx.fruitflybrain.org by double clicking on the "LAM" LPU, and then double clicking on any of the cartridges when the lamina page is brought up. The circuit diagram is drawn based on EM data [13]. By clicking on the "Load Cartridge" button, the cartridge model will be constructed from queries retrieving data from the NeuroArch database.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…For example, functional genomics data is provided by the Drosophila RNAi Screening Center (DRSC) and Transgenic RNAi Project (TRiP) [9], RNAi Libraries by the Vienna Drosophila Research Center [10] and FlyLight GAL4 and Split-GAL4 lines by the HHMI Janelia Research Campus [11,12]. Furthermore, EM-based data has been provided for the lamina cartridge [13], medulla [14,15] and mushroom body [16]. Most recently, the whole fly brain has been imaged using EM [17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Fruit Fly Brain Observatory: From Structure to Function

Nh¹,

C²,

Tomkins

et al. 2019

Preprint

View full text Add to dashboard Cite

The fruit fly is a key model organism for studying the activity of interconnected brain circuits. A large scattered global research community of neurobiologists and neurogeneticists, computational and theoretical neuroscientists, and computer scientists and engineers has been developing a vast trove of experimental and modeling data that has yet to be distilled into new knowledge and understanding of the functional logic of the brain. Developing open shared models, modelling tools and data repositories that can be accessed from anywhere in the world is the necessary engine for accelerating our understanding of how the brain works.To that end we developed the Fruit Fly Brain Observatory (FFBO), the next generation open-source platform to support open, collaborative Drosophila neuroscience research. FFBO provides a (i) hub for storing and integrating fruit fly brain research data from multiple data sources worldwide, (ii) unified repository of tools and methods to build, emulate and compare fruit fly brain models in health and disease, and (iii) an open framework for fruit fly brain data processing and model execution. FFBO provides access to application tools for visualizing, configuring, simulating and analyzing computational models of brain circuits of the (i) cell type map, (ii) connectome, (iii) synaptome, and (iv) activity map using intuitive queries in plain English. Tools are provided to extract the function inherent in these structural maps. All applications can be accessed with any modern browser.

show abstract

Comparative Connectomics

Heuvel

Bullmore

Sporns

2016

Trends in Cognitive Sciences

299

239

View full text Add to dashboard Cite

We introduce comparative connectomics, the quantitative study of cross-species commonalities and variations in brain network topology that aims to discover general principles of network architecture of nervous systems and the identification of species-specific features of brain connectivity. By comparing connectomes derived from simple to more advanced species, we identify two conserved themes of wiring: the tendency to organize network topology into communities that serve specialized functionality and the general drive to enable high topological integration by means of investment of neural resources in short communication paths, hubs, and rich clubs. Within the space of wiring possibilities that conform to these common principles, we argue that differences in connectome organization between closely related species support adaptations in cognition and behavior.

show abstract

Wiring Economy and Volume Exclusion Determine Neuronal Placement in the Drosophila Brain

Cited by 13 publications

References 0 publications

The glia of the adult Drosophila nervous system

The glia of the adult Drosophila nervous system

The Fruit Fly Brain Observatory: From Structure to Function

Comparative Connectomics

Contact Info

Product

Resources

About